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| 1 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 2 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | Quality-Aware Massive Content Delivery in Digital Twin-Enabled Edge Networks显示文摘Massive content delivery will become one of the most prominent tasks of future B5G/6G communication.However,various multimedia applications possess huge differences in terms of object oriented(i.e.,machine or user)and corresponding quality evaluation metric,which will significantly impact the design of encoding or decoding within content delivery strategy.To get over this dilemma,we firstly integrate the digital twin into the edge networks to accurately and timely capture Quality-of-Decision(QoD)or Quality-of-Experience(QoE)for the guidance of content delivery.Then,in terms of machinecentric communication,a QoD-driven compression mechanism is designed for video analytics via temporally lightweight frame classification and spatially uneven quality assignment,which can achieve a balance among decision-making,delivered content,and encoding latency.Finally,in terms of user-centric communication,by fully leveraging haptic physical properties and semantic correlations of heterogeneous streams,we develop a QoE-driven video enhancement scheme to supply high data fidelity.Numerical results demonstrate the remarkable performance improvement of massive content delivery. | Yun Gao Junqi Liao Xin Wei Liang Zhou | 2023 | China Communications2023，20，2： | 1 |
| 4 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 5 | Study on C-W Inter- actions by Molecular Dynamics Simulations显示文摘 | Yang Zhongshi Xu Q Liao Junqi | 2009 | Nuclear In- stnnnents and Methods in Physics Research2009，267，18： | 1 |
| 6 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 7 | A multi-mode multi-skill project scheduling reformulation for reconnaissance mission planning显示文摘Dear editor,Planning multi-agents scheduling to conduct reconnaissance missions is the core of reconnaissance decision support system.A reconnaissance mission comprises several tasks and a network representing precedence relationships between them,where each task represents an area in which the agents perform information gathering. | Junqi CAI Zhihong PENG Sijian LIAO Shuxin DING | 2022 | Science China(Information Sciences)2022，65，6： | 0 |
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