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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Porcine mannan-binding lectin A binds to actinobacillus snis and Hatmophilus parasuu显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 3 | Risk factors for functional status decline in community-living elderly people:a systematic literature review显示文摘 | Andreas E Stuck N Jutta M | | 0，，： | 1 |
| 4 | Porcine mannan-binding leetin A binds to Actinobacillus suis and Haemophilus parasuis 显示文摘 | Brandon N Jutta D Janet I | 2006 | Developmental and ComparativeImmunology2006，30，： | 1 |
| 5 | Porcine mannan-binding lectin A bind to Actinobacillus suis and Haemophilus parasuis显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and comparative immunology2006，30，10： | 1 |
| 6 | Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis 显示文摘 | Brandon N Jutta D Janet I | 2006 | Developmental and Comparative hnmunology2006，30，： | 1 |
| 7 | Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster 显示文摘 | Jutta N Anita K Stefan S | 2002 | Infection and Immunity2002，70，5： | 1 |
| 8 | Changes in the preserved heart that limit the length of preservation显示文摘 | Thomas N Alexander AF Jutta S | 2002 | J Heart Lung Transplant2002，21，： | 1 |
| 9 | Parallel bubble columns with fed-batch technique for microbial process development on a small scale显示文摘 | Jutta A R Christina N Matthias A | 1999 | Chem Eng Technol1999，22，12： | 1 |
| 10 | Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor显示文摘 | Jens K Jutta N Marieke W | 2007 | Blood2007，110，10： | 1 |
| 11 | Rating scales for the assessment of empathic communication in medical interviews (REM): scale development, reliability and validity显示文摘 | Jennifer N Ralf D Jutta H | 2007 | J Clin Psychol Med Settings2007，14，： | 1 |
| 12 | Parallel bubble columns with fed-batch technique for microbial process development on a small scale显示文摘 | Jutta A R Christina N Matthias A | 1999 | Chem Eng Technol1999，22，12： | 1 |
| 13 | Parallel substrate feeding and pH-control in shaking-flasks显示文摘 | Dirk W B Jutta A R Christina N | 2001 | Biochem Eng J2001，7，： | 1 |
| 14 | Changes in the preserved heart that limit the length of preservation显示文摘 | Thomas N Masters Alexander A Fokin Jutta Schaper Lieven Pool Geoffrey Gong Francis Robicsek | 2001 | Journal of Heart and Lung Transplantation2001，，5： | 1 |
| 15 | Factors affecting recovery of endotoxin adsorbed to container surfaces显示文摘 | THOMAS J N JUTTA S G JAMES F R | 1986 | Journal of Parenteral Science and Technology1986，40，： | 1 |
| 16 | Porcine mannanbinding lectin n binds to Actinobacillus suis and Haemophilus parasuis显示文摘 | BRANDON N JUTTA D HAMMERMUELLER | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 17 | Porcine mannan-binding lectin A bind to Actinobacillus suis and Haemophilus parasuis 显示文摘 | BRANDON N L JUTTA D H JANET I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 18 | SYFPEITHI:database for MHC ligan-ds and peptide motifs显示文摘 | Hans-Georg R Jutta B Niels Philipp N | 1999 | Immun1999，50，3： | 1 |
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