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| 1 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 2 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | Stathmin-tubulin inter-action gradients in motile and mitotic cells显示文摘 | NiethanunerP BastiaensP KarsentiE | 2004 | Science2004，303，5665： | 1 |
| 4 | The family of bone morphogenetic proteins显示文摘 | DUCY P KARSENTY G | 2000 | Kidney Int2000，57，6： | 1 |
| 5 | In vivo analysis of Wnt signaling in bone显示文摘 | Glass DA 2nd Karsenty G | 2007 | Endocrinology2007，148，6： | 1 |
| 6 | Adaptive eontrol of nonlinear systems with nonlinear parameterization 显示文摘 | Karsenti L Lamnabhi-Lagarrigue F Bastin G | 1996 | System and Control Letters1996，27，6： | 1 |
| 7 | The genetic transform ation of bone biology 显示文摘 | Karsenty G | 1999 | Genes Dev1999，13，23： | 1 |
| 8 | The mitotic spindlea self-made machine 显示文摘 | Karsenti E Vernos I | 2001 | Science2001，294，5542： | 1 |
| 9 | Climate Change Mitigation: Should 'Avoided Deforestation' Be Rewarded? 显示文摘 | Pirard R Karsenty A | 2009 | Journal of Sustainable Forestry2009，28，35： | 1 |
| 10 | The central regulation of bone mass, the first link between bone remodeling and energy metabolism 显示文摘 | KARSENTY G OURY F | 2010 | Clin Endocrinol Metab2010，95，47： | 1 |
| 11 | Leptin regulation of bone resorption by the sympathetic nervous system and CART显示文摘 | Elefteriou F Ahn JD Karsenty G | 2005 | Nature2005，3434，7032： | 1 |
| 12 | Towards a serotonin-de pendent leptin roadmap in the brain显示文摘 | OURY F KARSENTY G | 2011 | Trends En- docrinol Metab2011，22，9： | 1 |
| 13 | Economic Development and International Wransation in Service 显示文摘 | Hoekamana Karsenty | 1992 | Development Policy Review1992，，10： | 1 |
| 14 | The osteoblast:A sophisticated fibroblast under central surveil ance显示文摘 | Ducy P Schinke T Karsenty G | | 0，，5484： | 1 |
| 15 | In vivo analysis of Wnt signaling in bone显示文摘 | Glass DA Karsenty G | 2007 | Endocrinology2007，148，6： | 1 |
| 16 | The family of bone morphogenetic proteins 显示文摘 | Ducy P Karsenty G | 2000 | Kidney Int2000，57，6： | 1 |
| 17 | Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes显示文摘 | Kehat I Karsenti DK Snir M | 2001 | J Clin Res2001，108，3： | 1 |
| 18 | The complexities of skeletal biology显示文摘 | Karsenty G | 2003 | Nature2003，423，： | 1 |
| 19 | In vivo analysis of Wnt signaling in bone显示文摘 | Glass DA Karsenty G | | 0，，06： | 1 |
| 20 | Activation of the phosphatase activity of human Cdc25A by a CDK2-cyclin E dependent phosphorylation at the GI/S transition 显示文摘 | Hoffmann I Draetta G Karsenti E | 1994 | EMBO J1994，13，18： | 1 |
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