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| 1 | A Study on the Protective Effect of Cynodon dactylon Leaves Extract in Diabetic Rats显示文摘Objective To investigate the antidiabetic, antioxidant and hypolipidemic efficacy of Cynodon dactylon in diabetic rats. Methods The experimental rats were randomly divided into three groups: Group I: control; Group II: Alloxan diabetic, untreated; and Group III: Alloxan diabetic treated with ethanolic extract of C. dactylon leaves (450 mg/kg bw). Experimental diabetes was induced by alloxan in a single dose of 150 mg/kg bw. Results A Significant diminution of fasting blood sugar level was observed and also significant increase in HDL and decrease (P<0.05) in cholesterol, triglyceride, LDL and VLDL were observed after 15 days of treatment. The investigation also revealed, the activities of AST, ALT, ALP, AP, LDH, and CPK (P<0.05) were decreased in the extract‐supplemented group. The significant decrease in protein content and SOD, CAT, GPx, and GSH (P<0.05) activity and increase in LPO in plasma were found to be ameliorated after treatment. Conclusion Our result supports the fact that administration of extract of C. dactylon leave is able to reduce hyperglycemia and hyperlipidemia risk and also reduced the oxidative stress in diabetic rats. | Karthik D Ravikumar S | 2011 | Biomedical and Environmental Sciences2011，24，2： | 10 |
| 2 | Controversies in fluid therapy: Type, dose and toxicity显示文摘Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ‘‘crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity(fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy basedon functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity(fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ‘‘default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients. | Robert C McDermid Karthik Raghunathan Adam Romanovsky Andrew D Shaw Sean M Bagshaw | 2014 | World Journal of Critical Care Medicine2014，3，1： | 5 |
| 3 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 4 | Optimizing model complexity with application to fuel cell based power systems显示文摘 | Karthik Subramanyan Urmial M D | 2007 | Chemical Engineering and Processing2007，46，11： | 1 |
| 5 | Multi- objective optimization for hybrid fuel cells power system under uncertainty显示文摘 | Karthik Subramanyan Urmial M D | 2004 | Journal of Power Sources2004，134，12： | 1 |
| 6 | Video fingerprinting and encryption principles for digital rights management显示文摘 | KUNDUR D KARTHIK K | 2004 | IEEE Multimedia2004，92，6： | 1 |
| 7 | The evolution, challenges, and future of knowledge rep- resentation in product design systems 显示文摘 | Senthil K Chandrasegaran Karthik Ramani Ram D Sriram | 2013 | Computer-Aided Design2013，45，2： | 1 |
| 8 | Wavelet Based Spectrum Sensing Techniques for Cognitive Radio-A Survey 显示文摘 | KARTHIK D NAVEEN M P | 2011 | International Journal of Computer Science & Information Technology2011，3，2： | 1 |
| 9 | Left internal mammary artery to the left anterior descending artery: effect on morbidity and mortality and reasons for nonusage显示文摘 | Karthik S Srinivasan A K Grayson A D | 2004 | Ann Tho rac Surg2004，78，1： | 1 |
| 10 | Association of endothelial nitric oxide synthase gene polymorphisms with early-onset ischemic stoke in south indians显示文摘 | Majumdar V Nagaraja D Karthik N | 2010 | J Atheroscler Thromb2010，17，1： | 1 |
| 11 | Video fingerprinting and encryption principles for digital rights management显示文摘 | KUNDUR D KARTHIK K | 2004 | Proceedings of the IEEE2004，92，6： | 1 |
| 12 | Video fingerprinting and encryption principles for digital rights management 显示文摘 | Kundur D Karthik K | 2004 | Proceedings of the IEEE2004，92，8： | 1 |
| 13 | Variability of Sheet Formability and Formability Testing 显示文摘 | Karthik V Comstock R J Hershberger D L et a1 | 2002 | Journal of Materials Processing Technology2002，121，23： | 1 |
| 14 | Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats显示文摘 | Karthik D Viswanathan P Anuradha CV | | 0，，： | 1 |
| 15 | Video fingerprinting and encryption principles for digital rights management显示文摘 | Kundur D and Karthik K | 2004 | 1EEE Multimedia2004，92，6： | 1 |
| 16 | Video tinge -rprinting and eneryption principles for digital rights management 显示文摘 | KUNDUR D KARTHIK K | 2004 | Proceedings IEEE2004，92，6： | 1 |
| 17 | Micmstructural characterization and pore structure analysis of nuclear graphite 显示文摘 | Kane J Karthik C Butt D P et ol | 2011 | Journal of Nuclear Materials2011，415，2： | 1 |
| 18 | Cryoplasty for arterial restenosis 显示文摘 | Karthik S Tuite D J Nicholson AA | 2007 | Eur J Vasc Endovasc Surg2007，33，1： | 1 |
| 19 | Proteomic Analysis of Plasma Proteins in Diabetic Rats by 2D Electrophoresis and MALDI-TOF-MS显示文摘 | Karthik D Ilavenil S Kaleeswaran B | 2012 | Appl Biochem Biotechnol2012，166，6： | 1 |
| 20 | Video fingerprinting and encryption principles for digital rights man?agement显示文摘 | KUNDUR D KARTHIK K | 2004 | Proceedings of the IEEE2004，92，6： | 1 |
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