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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Fungi from geothermal soils in Yellowstone National Park显示文摘 | Regina S R Anastassial L Kathy BS | 1999 | Applied Environment Microbiology1999，65，12： | 1 |
| 3 | Molecular characterisation of hepatopancreatic parvovirus (PmergDNV) from Australian Penaeus merguiensis显示文摘 | Kathy A L Jennifer E Leigh O | 2007 | Virology2007，362，： | 1 |
| 4 | A new Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation显示文摘 | Mary E Charlson Peter Pompei Kathy L A | 1987 | J Chron Dis1987，，40： | 1 |
| 5 | E- Business Education at AACSB- Affiliated Business Schools: a Survey of Programs and Curricula显示文摘 | Harlan L Kathy H | 2001 | Journal of Education for Business2001，，7： | 1 |
| 6 | Calming Complainers显示文摘 | Indermill Kathy L | 1990 | Restaurant Hospitality ABI/INFORM Global1990，74，10： | 1 |
| 7 | Genetic variation in the foliar pathogen Dothistroma septosporum and relationship to toxin production显示文摘 | Angie D Kathy L | 2005 | FSP Project2005，，： | 1 |
| 8 | Contaminant Transport in High Arctic Soils:A Tracer Experiment显示文摘 | Kathy L | 2005 | Permafrost and Periglac Process2005，16，： | 1 |
| 9 | Neighborhood school characteristics:what signals quality to homebuyers显示文摘 | KATHY J HAYES LORI L TAYLOR | 1996 | Federal Reserve Bank of Dallas Economic Review1996，，3： | 1 |
| 10 | Sleeppromotion in hospitalized elder 显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Mcd Surg Nursing2003，，12： | 1 |
| 11 | Patient access and clini-cal efficiency improvement in a resident hospital-basedwomen’s medicine center clinic显示文摘 | Stephen H Michael R Kathy L | 2007 | The American Journal ofManaged Care2007，13，12： | 1 |
| 12 | Planning for Leisure:Issues of Quality of Life显示文摘 | KATHY L | 1996 | Social Alternative1996，15，2： | 1 |
| 13 | Sleep promotion in hospitalized elder显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Med Surg Nursing2003，，12： | 1 |
| 14 | E-business Education at AACSB- Affiliated Business Schools: A Survey of Programs and Curricula显示文摘 | Harlan L Etheridge Kathy H Y Hsu Thomas E Wilson Jr | 2001 | Journal of Education for Business2001，，： | 1 |
| 15 | Neoadjuvant Therapy for Breast Cancer显示文摘 | Stephen L Laleh M Kathy Y | | 0，，04： | 1 |
| 16 | Neoadjuvant Therapy Breast Canc- er显示文摘 | Stephen L laleh M Kathy Y | 2010 | J Surg Oncol2010，101，4： | 1 |
| 17 | Wear performance of ultrahigh molecular weight polyethylene/quartz composites显示文摘 | Xie X L Tang C Y Kathy Y Y Chan | 2003 | Biomaterials2003，24，： | 1 |
| 18 | Avoidance of ven- tricular pacing in cardiac resynchronization therapy im- proves right ventricular hemodynamics in heart failure patients显示文摘 | Kathy L John E Thomas J | 2007 | J Cardiovasc Electrophysiol2007，18，： | 1 |
| 19 | Neoadjuvant therapy for breast cancer显示文摘 | STEPHEN L LALEH M KATHY Y | 2010 | J Surg O ncol2010，101，4： | 1 |
| 20 | Neoadjuvant therapy for breast cancer显示文摘 | Stephen L Laleh M Kathy Y | | 0，，04： | 1 |
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