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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Molecular characterisation of hepatopancreatic parvovirus (PmergDNV) from Australian Penaeus merguiensis显示文摘 | Kathy A L Jennifer E Leigh O | 2007 | Virology2007，362，： | 1 |
| 3 | A new Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation显示文摘 | Mary E Charlson Peter Pompei Kathy L A | 1987 | J Chron Dis1987，，40： | 1 |
| 4 | TaqMan real-time PCR for detection of hepatopancreatic parvovirus from Australia显示文摘 | Kathy A L Ramon L Leigh O | 2007 | J Virol Methods2007，140，： | 1 |
| 5 | Age and growth of king and Spanish mackerel larvae and juveniles from the gulf of mexico and U S south atlantic bight 显示文摘 | Duglas A V Churchill B G Kathy L L | 1990 | Enviroment Biol Fish1990，29，2： | 1 |
| 6 | Clinical Trial of a Home Safety Toolkit for Alzheimer's Disease显示文摘 | Kathy J Horvath Scott A Trudeau James L Rudolph | 2013 | International Journal of Alzheimer''s Disease2013，2013，91： | 1 |
| 7 | Solubilization of manganese dioxide-bound copper by naturally occurring organic compounds 显示文摘 | Kathy L Godtfredsen and Stone A T | 1994 | Environ SciTechnol1994，28，： | 1 |
| 8 | Spotting optimization for oligo microarrays on aldehyde-glass显示文摘 | Reppert A E Rowlen Kathy L | 2005 | Analyt Biochem2005，341，： | 1 |
| 9 | The dose-volume realationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer显示文摘 | Kathy L Baglan Robert C Frazier Di Yan Raywin R Huang Alvaro A Martinez John M Robertson | 2002 | International Journal of Radiation Oncology Biology Physics2002，，1： | 1 |
| 10 | Morphological abnormalities and sensorimotor deficits in larval fish exposed to dissolved saxitoxin 显示文摘 | KATHI A LEFEBVRE VERA L | 2004 | Aquatic Toxicology2004，66，： | 1 |
| 11 | The dose-volume realationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer显示文摘 | Kathy L Baglan Robert C Frazier Di Yan Raywin R Huang Alvaro A Martinez John M Robertson | 2002 | International Journal of Radiation Oncology, Biology, Physics2002，，： | 1 |
| 12 | Safety and efficacy of elective carotid artery stenting in high-risk patients显示文摘 | Fayaz Shawl Waleed Kadro Michael J Domanski Fernando L Lapetina Aleem A Iqbal Kathy G Dougherty David D Weisher Jaime F Marquez S.Tariq Shahab | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 13 | Race and colorectal cancer screening compliance among persons with a family history of cancer显示文摘AIM: To determine compliance to colorectal cancer(CRC) screening guidelines among persons with a family history of any type of cancer and investigate racial differences in screening compliance.METHODS: We used the 2007 Health Information National Trends Survey and identified 1094(27.4%)respondents(weighted population size = 21959672) without a family history of cancer and 3138(72.6%) respondents(weighted population size = 58201479) with a family history of cancer who were 50 years and older. We defined compliance with CRC screening as the use of fecal occult blood testing within 1 year, sigmoidoscopy within 5 years, or colonoscopy within 10 years. We compared compliance with CRC screening among those with and without a family member with a history of cancer. RESULTS: Overall, those with a family member with cancer were more likely to be compliant with CRC screening(64.9% vs 55.1%; OR = 1.45; 95%CI: 1.20-1.74). The absolute increase in screening rates associated with family history of cancer was 8.2% among whites. Hispanics had lowest screening rates among those without family history of cancer 41.9% but had highest absolute increase(14.7%) in CRC screening rate when they have a family member with cancer. Blacks had the lowest absolute increase in CRC screening(5.3%) when a family member has a known history of cancer. However, the noted increase in screening rates among blacks and Hispanics when they have a family member with cancer were not higher than whites without a family history of cancer:(54.5% vs 58.7%; OR = 1.16; 95%CI: 0.72-1.88) for blacks and(56.7% vs 58.7%; OR = 1.25; 95%CI: 0.72-2.18) for Hispanics.CONCLUSION: While adults with a family history of any cancer were more likely to be compliant with CRC screening guidelines irrespective of race/ethnicity, blacks and Hispanics with a family history of cancer were less likely to be compliant than whites without a family history. Increased burden from CRC among blacks may be related to poor uptake of screening among high-risk groups. | Adeyinka O Laiyemo Nicole Thompson Carla D Williams Kolapo A Idowu Kathy Bull-Henry Zaki A Sherif Edward L Lee Hassan Brim Hassan Ashktorab Elizabeth A Platz Duane T Smoot | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，18： | 0 |
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