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| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Danggui-shaoyao-san, a traditional Chinese medicine prescription, alleviates the orthodontic pain and inhibits neuronal and microglia activation显示文摘 | Li Hongshi Gu Zexu Wu Li'an Xia Liang Zhou Kecheng E Lingling Wang Dongsheng Kou Junping Liu Hongchen | 2014 | Chinese Medical Journal2014，，20： | 4 |
| 3 | Cyclic Ether Contaminant Removal from Water Using Nonporous Adaptive Pillararene Crystals via Host-Guest Complexation at the Solid-Solution Interface显示文摘Te removal of soluble cyclic ether contaminants,such as dioxane and THF,produced in industrial chemical processes from water is of great importance for environmental protection and human health.Here we report that nonporous adaptive crystals of perethylated pillar[5]arene(EtP5)and pillar[6]arene(EtP6)work as adsorbents for cyclic ether contaminant removal via hostguest complexation at the solid-solution interface.Nonporous EtP6 crystals have the ability to adsorb dioxane from water with the formation of 1:2 host-guest complex crystals,while EtP5 crystals cannot.However,both guest-free EtP5 and EtP6 crystals remove THF from water with EtP5 having a better capacity.Tis is because EtP5 forms a 1:2 host-guest complex with THF via host-guest complexation at the solid-solution interface while EtP6 forms a 1:1 host-guest complex with THF.EtP6 also shows the ability to selectively remove dioxane from water even in the presence of THF.Moreover,the reversible transitions between nonporous guestfree EtP5 and EtP6 structures and guest-loaded structures make them highly recyclable. | Yujuan Zhou Kecheng Jie Run Zhao Errui Li Feihe Huang | 2019 | Research2019，，1： | 2 |
| 4 | Effect of B203 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li20-Nb205 3TiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li | 2009 | Journal of Materials Science:Mater Electron2009，20，： | 1 |
| 5 | The Efficacy Evaluation of Cryosurgery in Pancreatic Cancer Patients with the Expression of CD44v6, Integrin-β1, CA199, and CEA显示文摘 | Gang Zhou David Chiu Dajiang Qin Lizhi Niu Jinlei Cai Lihua He Wenhao Huang Kecheng Xu | 2012 | Molecular Biotechnology2012，，1： | 1 |
| 6 | Compar- ative study on the dynamic heat transfer characteristics of PCM-filled glass window and hollow glass window 显示文摘 | Shuhong Li Kecheng Zhong Yingying Zhou | 2014 | Energy and Buildings2014，85，： | 1 |
| 7 | Effect of B2O3 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li2O–Nb2O5–3TiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li Xi Yao | 2009 | Journal of Materials Science: Materials in Electronics2009，，3： | 1 |
| 8 | Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients显示文摘 | Gang Zhou Lizhi Niu David Chiu Lihua He Kecheng Xu | 2012 | Biotechnology Letters2012，，7： | 1 |
| 9 | Ef feet of B2O3 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li2O-Nb2O5-3YiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li and Xi Yao | 2009 | J Mater Sci:Mater Electron2009，20，： | 1 |
| 10 | Gynecologic infections seen in ThinPrep cytological test in Wuhan, China显示文摘这研究试图分析流行细菌,在 ThinPrep cytological 测试(TCT ) 的 Candida, Trichomonas,和人的乳头状瘤病毒(HPV ) 感染表现在中国武汉的女人上。ThinPrep 油迹被二个独立富有经验的病理学家屏蔽并且从 2008 ~ 2010 报导了。46 866 ThinPrep 油迹的一个总数被学习,并且有发炎的油迹被分析。44 162 个注册病人,发炎变化被观察在 21 935 (49.7%) 并且在 6884 的特定的感染(31.4%) 。检测的感染如下:细菌, 5663 (82.3%) ;Candida, 825 (12.0%) ;Trichomonas, 273 (4.0%) ;并且 HPV, 148 (2.1%) 。重要变化在在 2010 前后经历了 TCT 的女人之中在细菌和 Candida 的流行被发现。< 啜 class= “ a-plus-plus ” > 2 揭示了在 2010 以后在油迹发现的特定的感染的一个增加的比例(P = 0.000 ) 。在结论,细菌的感染在 ThinPrep 油迹是最可检测的,由 Candida 和 Trichomonas 列在后面。TCT 识别的感染的流行被发现在在中国的以前的文学类似。 | Hang Zhou Yao Jia Jian Shen Shaoshuai Wang Xiong Li Ru Yang Kecheng Huang Ting Hu Fangxu Tang Jin Zhou Jingping Yuan Lei Huang Xun Tian Zhilan Chen Qinghua Zhang Changyu Wang Ling Xi Dongrui Deng Hui Wang Ding Ma Shuang Li | 2014 | Frontiers of Medicine2014，8，2： | 1 |
| 11 | Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients显示文摘 | Gang Zhou Lizhi Niu David Chiu Lihua He Kecheng Xu | 2012 | Biotechnology Letters2012，，7： | 1 |
| 12 | Effect of B2 Os and CuO additions on the sintering tem- perature and microwave dielectric properties of 3Li20- Nb2O5-3TiO2 ceramics 显示文摘 | ZHOU Huanfu WANG Hong LI Kecheng | 2009 | Journal of Materials Sci- ence Materials in Electronics2009，20，3： | 1 |
| 13 | A leap by the rise of solid-state electrolytes for Li-air batteries显示文摘Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs. | Kecheng Pan Minghui Li Weicheng Wang Shuochao Xing Yaying Dou Shasha Gao Zhang Zhang Zhen Zhou | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 14 | CRISPR accelerates the cancer drug discovery显示文摘Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients,such as gene mutation,amplification,or deletion,with the overall survival prognosis,underscoring patients’genetic background may directly regulate drug sensitivity/resistance during chemotherapies.Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery.The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research,providing a precise and simplified genome editing tool with unlimited editing possibilities.Furthermore,it presents a powerful tool in cancer drug discovery,which hopefully facilitates us with a rapid and reliable manner in developing novel therapies and understanding the molecular mechanisms of drug sensitivity/resistance.Herein,we summarized the application of CRISPR/Cas9 in drug screening,with the focus on CRISPR/Cas9 mediated gene knockout,gene knock-in,as well as transcriptional modification.Additionally,this review provides the concerns,cautions,and ethnic considerations that need to be taken when applying CRISPR in the drug discovery. | RUYU YAN JUNJIE WANG MINXIA LIU KECHENG ZHOU | 2022 | BIOCELL2022，46，10： | 0 |
| 15 | Investigation on Noise Pollution Comprehensive Treatment of Distribution Transformer in Living Area显示文摘In the current paper,which deals with the noise pollution excited by distribution transformers in the living area,a comprehensive treatment scheme is put forward for the purpose of reducing the sound pressure level emitting into the environment.In accordance with the associated test standard,the sound pressure levels of distribution transformer and surrounding environment are not only tested but analyzed as well.The measurements were carried out with the frequency analysis of the 1/3 octave resolution,with the center frequencies at 125 Hz,250 Hz,400 Hz,and 500 Hz.As illustrated,on the basis of the measurement results,the frequency of noise at 500 Hz of distribution transformer causes the major noise pollution in the surrounding environment.This measurement result is in line with the noise frequency characteristics of distribution transformer.There are two transmission routes of noise:(i)the noise excited by distribution transformer transmits by means of the wall of distribution room,and (ii)part of noise spreads through the ground of distribution room.Accordingly,acoustic shield and vibration isolation device are applied for the reduction of the low frequency noise emitted through the above two paths.Aimed at applying the appropriate acoustic material and vibration mounting,the evaluation of the noise reduction and vibration absorption is carried out in accordance with the sound and vibration insulation theory.Following the noise treatment,the transformer and environment noise are measured again.The corresponding findings shed light on the fact that the sound level satisfied the requirement of limits of the ordinance.The proposed noise treatment scheme can be applied to the existing power distribution facilities for controlling the sound levels that reach a point where it is comparatively more unobjectionable. | Li Li Xiaopeng Fan Kecheng Wu Zhuanglei Zou Yongyan Zhou Dianhai Zhang Ziyan Renand Yanli Zhang | 2019 | Sound & Vibration2019，53，6： | 0 |
| 16 | Systematic co-delivery of dual agonists to enhance cancer immunotherapy显示文摘In the tumor immunosuppressive microenvironment(TIME),antigen presenting cells(APCs)usually exhibit a tumor suppressor phenotype.Toll-like receptors(TLRs)agonists could reprogram M2-type macrophages to M1-type and stimulate dendritic cells(DCs)maturation.The combination of TLR7/8 and TLR9 agonists seems to have synergistic therapeutic efficacy.Here,we designed a lipid-coated mesoporous silica nanoparticle(MSNs@Lipo)for the co-delivery of TLR7/8 agonist resiquimod(R848)and TLR9 agonist CpG oligodeoxynucleotides(ODNs)(CpG@MSNs-R@L-M).R848 was firstly conjugated onto the nanoparticle via silane chemistry,which is acidic responsive drug release.Then,CpG was loaded onto the nanoparticle through the positive charge mainly from TLR7/8 agonist R848.Our in vitro experiments further indicated that both drugs have acid-responsive release properties and could be taken up by DCs and located on the endosomes of APCs.More importantly,CpG@MSNs-R@L-M could significantly improve the antitumor efficacy in B16F10 melanoma model.The mechanistic study demonstrated that CpG@MSNsR@L-M could remarkably modulate the TIME by promoting the maturation of DCs and repolarizing macrophages from M2 to M1 phenotype and facilitating the infiltration of tumor cytotoxic T cells.It was concluded that in comparison to single agonist,the codelivery of dual agonists,CpG and R848,can improve anti-tumor immune responses for cancer immunotherapy. | Xiangxia Li Guiyuan Chen Yangyi Wang Lanhong Su Bo Chen Kecheng Wu Yun Xing Zechenxi Song Ruike Dai Tianxin Liu Jiaao Zhao Zhe Xie Peijie Zhou Xiaoping Xia Yuanzeng Min | 2022 | Nano Research2022，15，9： | 0 |
| 17 | Cu/Mo2C synthesized through Anderson-type polyoxometalates modulate interfacial water structure to achieve hydrogen evolution at high current density显示文摘The development of efficient non-precious metal catalysts is important for the large-scale application of alkaline hydrogen evolution reaction(HER).Here,we synthesized a composite catalyst of Cu and Mo_(2)C(Cu/Mo_(2)C)using Anderson-type polyoxometalates(POMs)synthesized by the facile soaking method as precursors.The electronic interaction between Cu and Mo_(2)C drives the positive charge of Cu,alleviating the strong adsorption of hydrogen at the Mo site by modulating the d-band center of Mo_(2)C.By studying the interfacial water structure using in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS),we determined that the positively charged Cu crystals have the function of activating water molecules and optimizing the interfacial water structure.The interfacial water of Cu/Mo_(2)C contains a large amount of free water,which could facilitate the transport of reaction intermediates.Due to activated water molecules and optimized interfacial water structure and hydrogen adsorption energy,the overpotential of Cu/Mo_(2)C is 24 mV at a current density of 10 mA·cm^(-2) and 178 mV at a current density of 1000 mA·cm^(-2).This work improves catalyst performance in terms of interfacial water structure optimization and deepens the understanding of water-mediated catalysis. | Dunyuan Jin Fen Qiao Yan Zhou Junfeng Wang Kecheng Cao Jing Yang Jikang Zhao Lei Zhou Haitao Li | 2024 | Nano Research2024，17，4： | 0 |
| 18 | Hydrophobic Small-Molecule Polymers as High-Temperature-Resistant Inhibitors in Water-Based Drilling Fluids显示文摘Water-based drilling fluids can cause hydration of the wellbore rocks,thereby leading to instability.This study aimed to synthesize a hydrophobic small-molecule polymer(HLMP)as an inhibitor to suppress mud shale hydration.An infrared spectral method and a thermogravimetric technique were used to characterize the chemical composition of the HLMP and evaluate its heat stability.Experiments were conducted to measure the linear swelling,rolling recovery rate,and bentonite inhibition rate and evaluate accordingly the inhibition performance of the HLMP.Moreover,the HLMP was characterized through measurements of the zeta potential,particle size distribution,contact angles,and interlayer space testing.As confirmed by the results,the HLMP could successfully be synthesized with a favorable heat stability.Furthermore,favorable results were found for the inhibitory processes of the HLMP on swelling and dispersed hydration during mud shale hydration.The positively charged HLMP could be electrically neutralized with clay particles,thereby inhibiting diffusion in the double electron clay layers.The hydrophobic group in the HLMP molecular structure resulted in the formation of a hydrophobic membrane on the rock surface,enhancing the hydrophobicity of the rock.In addition,the small molecules of the HLMP could plug the spaces between the layers of bentonite crystals,thereby reducing the entry of water molecules and inhibiting shale hydration. | Xuyang Yao Kecheng Liu Zenan Zhou Jun Zhou Xianbin Huang Tiemei Lu Yongsheng Yu He Li | 2023 | Fluid Dynamics & Materials Processing2023，19，7： | 0 |
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