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| 1 | High-contrast,fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser显示文摘Coherent Raman scattering(CRS)microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast,high spatial and spectral resolution,and high sensitivity.However,the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints.Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging,as previous implementations have suffered from high intensity noise,a narrow tuning range and low power,resulting in low image qualities and slow imaging speeds.Here,we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability(improved by 50 dB),timing jitter(24.3 fs),average power fluctuation(<0.5%),modulation depth(>20 dB)and pulse width variation(<1.8%)over an extended wavenumber range(2700-3550 cm^(−1)).The versatility of the laser source enables,for the first time,high-contrast,fast CRS imaging without complicated noise reduction via balanced detection schemes.These capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail,kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence,which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical diagnosis.This work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies. | Cihang Kong Christian Pilger Henning Hachmeister Xiaoming Wei Tom H.Cheung Cora S.W.Lai Nikki P.Lee Kevin K.Tsia Kenneth K.Y.Wong Thomas Huser | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 2 | High-energy all-fiber gain-switched thulium-doped fiber laser for volumetric photoacoustic imaging of lipids显示文摘We demonstrate a high-energy all-fiber short wavelength gain-switched thulium-doped fiber laser for volumetric photoacoustic(PA)imaging of lipids.The laser cavity is constructed by embedding a short piece of gain fiber between a pair of fiber Bragg gratings(FBGs).Through using three pairs of FBGs with operation wavelengths at1700,1725,and 1750 nm,three similar lasers are realized with a cavity length of around 25 cm.Under a maximum pump energy of 300μJ at 1560 nm,laser pulse energies of 58.2,66.8,and 75.3μJ are,respectively,achieved with a minimum pulse width of<16.7 ns at a repetition rate of 10 kHz.Volumetric imaging of lipids is validated through scanning a fat beef slice with a PA microscopy system incorporated with the newly developed source,and a lateral resolution of 18.8μm and an axial resolution of 172.9μm are achieved.Moreover,the higher shooting speed of the developed source can potentially allow for increasing at twice the frame rate of current intravascular PA imaging. | CAN LI JIAWEI SHI XIATIAN WANG BOQUAN WANG XIAOJING GONG LIANG SONG KENNETH K.Y.WONG | 2020 | Photonics Research2020，8，2： | 4 |
| 3 | Breathing dissipative soliton explosions in a bidirectional ultrafast fiber laser显示文摘Soliton explosions,among the most exotic dynamics,have been extensively studied on parameter invariant stationary solitons.However,the explosion dynamics are still largcly unexplored in breathing dissipative solitons as a dynamic solution to many nonlincar systems.Here,we report on the first observation of a breathing dissipative soliton explosion in a nct-normal-dispersion bidirectional ultrafast fiber lascr.The breathing soliton explos ionscould be stimulated by the soliton buildup process or alteration of polarization settings.Transient breathing soliton pairs with intensive repulsion that is sensitive to initial conditions can also be triggered by multiple soliton explosions in the soliton buildup process instead of being triggered by varying polarization settings.The high bchavior similarity also exists in the breathing soliton buildup and explosion process owing to the common gain and loss modulation.In addition,dissipative rogue waves were detected in the breathing soliton explosion,and the collision of breathing soliton significantly enhanced the amplitude of rogue waves,which is characteristic of the breathing solitons in a bidirectional fiber laser.These results shed new insights into complex dissipative soliton dynamics. | YI ZHOU YU-XUAN REN JIAWEI SHI KENNETH K.Y.WONG | 2020 | Photonics Research2020，8，10： | 4 |
| 4 | Pencil-beam scanning catheter for intracoronary optical coherence tomography显示文摘Current gradient-index(GRIN)lens based proximal-driven intracoronary optical coherence tomography(ICOCT)probes consist of a spacer and a GRIN lens with large gradient constant.This design provides great flexibility to control beam profiles,but the spacer length should be well controlled to obtain desired beam profiles and thus it sets an obstacle in mass catheter fabrication.Besides,although GRIN lens with large gradient constant can provide tight focus spot,it has short depth of focus and fast-expanded beam which leads to poor lateral resolution for deep tissue.In this paper,a type of spacer-removed probe is demonstrated with a small gradient constant GRIN lens.This design simplifies the fabrica-tion process and is suitable for mass production.The output beam of the catheter is a narrow nearly collimated light beam,referred to as pencil beam here.The full width at half maximum beam size varies from 35.1μm to 75.3μm in air over 3-mm range.Probe design principles are elaborated with probe/catheter fabrication and performance test.The in vivo imaging of the catheter was verified by a clinical ICOCT system.Those results prove that this novel pencil-beam scanning catheter is potentially a good choice for ICOCT systems. | Jiqiang Kang Rui Zhu Yunxu Sun Jianan Li Kenneth K.Y.Wong | 2022 | Opto-Electronic Advances2022，5，3： | 2 |
| 5 | Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array显示文摘Parallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional(3D)visualization of dynamical biological processes with minimal photodamage.However,the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three dimensions.We hereby develop a novel fluorescence imaging approach,called coded light-sheet array microscopy(CLAM),which allows complete parallelized 3D imaging without mechanical scanning.Harnessing the concept of an“infinity mirror”,CLAM generates a light-sheet array with controllable sheet density and degree of coherence.Thus,CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/scanning.Moreover,the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged volume.We demonstrate the utility of CLAM in different imaging scenarios,including a light-scattering medium,an optically cleared tissue,and microparticles in fluidic flow.CLAM can maximize the signal-to-noise ratio and the spatial duty cycle,and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging systems.The flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research. | Yu-Xuan Ren Jianglai Wu Queenie T.K.Lai Hei Ming Lai Dickson M.D.Siu Wutian Wu Kenneth K.Y.Wong Kevin K.Tsia | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 6 | Enhanced depth resolution in optical scanning holography using a configurable pupil显示文摘The optical scanning holography(OSH)technique can capture all the three-dimensional volume information of an object in a hologram via a single raster scan.The digital hologram can then be processed to reconstruct individual sectional images of the object.In this paper,we present a scheme to reconstruct sectional images in OSH with enhanced depth resolution,where a spatial light modulator(SLM)is adopted as a configurable point pupil.By switching the SLM between two states,different Fresnel zone plates(FZPs)are generated based on the same optical system.With extra information provided by different FZPs,a depth resolution at 0.7μm can be achieved. | Haiyan Ou Ting-Chung Poon Kenneth K.Y.Wong Edmund Y.Lam | 2014 | Photonics Research2014，2，2： | 2 |
| 7 | Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content显示文摘Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively,such as leveraging the vibrational absorption peak of the O-H bond.However,due to the lack of an efficient laser source,it was challenging to image the water content in the deep tissue with micron-level spatial resolution.To address this problem,we develop a high-power hybrid optical parametrically-oscillating emitter(HOPE)at 1930 nm,at which the vibrational absorption peak of the O-H bond locates.The maximum pulse energy is over 1.74μJ with a pulse repetition rate of 50 kHz and a pulse width of 15 ns.We employ this laser source in the optical-resolution photoacoustic microscopy(OR-PAM)system to image the water content in the phantom and the biological tissue in vitro.Our 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution,deep penetration depth,improved sensitivity,and suppressed artifact signal of the lipid. | Jiawei Shi Mingsheng Li Huajun Tang Jiqiang Kang Najia Sharmin Amir Rosenthal Kenneth K.Y.Wong | 2022 | eLight2022，2，1： | 1 |
| 8 | Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines显示文摘The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be characterised.In this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition. | Ye Peng Lin Zhang Chris K.P.Mok Jessica Y.L.Ching Shilin Zhao Matthew K.L.Wong Jie Zhu Chunke Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui Kuan Cheong Ka Long Ip Adrian C.H.Fung Kenneth K.Y.Wong David S.C.Hui Francis K.L.Chan Siew C.Ng Hein M.Tun | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 9 | Obesity in children and adolescents:Overview of the diagnosis and management显示文摘Childhood obesity is one of the biggest public health challenges globally.It is associated with various adverse health consequences throughout life.Prevention and early intervention represent the most reasonable and costeffective approaches.Considerable progress has been achieved in the management of obesity in children and adolescents;yet,implementation in the real world remains a challenge.This article aimed to present an overview of the diagnosis and management of obesity in children and adolescents. | Joanna Y.L.Tung Grace W.K.Poon Juan Du Kenneth K.Y.Wong | 2023 | Chronic Diseases and Translational Medicine2023，9，2： | 0 |
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