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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Seed phosphorus and inositol phosphate phenotype of barley low phytic acid geno- types 显示文摘 | John A D Allen C Kevin A Y | 2003 | Phytochemistry2003，62，5： | 1 |
| 3 | Long - range transport of anthropogenic aerosols to the National Oceanic and Atmospheric Administra- tion baseline station at Mauna Ix)a Observatory Hawaii 显示文摘 | Pen'y Kevin D Cahill Thomas A Schnell Russell C | 1999 | Journal of Geophysical Research1999，104，18： | 1 |
| 4 | Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis显示文摘 | Haim Y Cohen Siva Lavu Kevin J Bitterman Brian Hekking Thomas A Imahiyerobo Christine Miller Roy Frye Hidde Ploegh Benedikt M Kessler David A Sinclair | 2004 | Molecular Cell2004，，5： | 1 |
| 5 | Statistical reliability analyses of two plastic composite extrusion processes 显示文摘 | KEVIN A C TIMOTHY M Y DAVID H | 2011 | Journal of Applied Polymer Science2011，96，1： | 1 |
| 6 | Availability of phosphorus and trace elements in low- phytate varieties of barley and corn for rainbow trout (On- corhynchus mykiss) 显示文摘 | Shozo H S Victor R Kevin A Y | 1999 | Aquaculture1999，170，34： | 1 |
| 7 | Effect of pruning severity and timing of treatment on epicormie sprout development in giant sequoia 显示文摘 | Kevin L O Robert A Y Robert C H | 2008 | Forestry2008，81，1： | 1 |
| 8 | Virtual fluoroscopy:computer-assisted fluoroscopic navigation显示文摘 | Kevin T David A Raja Y | 2001 | Spine2001，26，4： | 1 |
| 9 | Nonlinear multigrid algorithms for bayesian optical diffusion tomagraphy 显示文摘 | JONG C Y CHARLES A B KEVIN J W | 2001 | IEEE Transaction on Image Processing2001，10，5： | 1 |
| 10 | Decontamination of fresh produce by the use of slightly acidic hypochlorous water following pretreatment with sucrose fatty acid ester under microbubble generation显示文摘 | KEVIN W S ASAKO Y MOTOMATSU A | 2010 | Food Control2010，21，9： | 1 |
| 11 | Seed phosphorus and inositol phosphate phenotype of harley low phytic acid genotypes 显示文摘 | JOHN A D ALLEN C KEVIN A Y | 2003 | Phytochemistry2003，62，5： | 1 |
| 12 | Globally decoupied reputations for large distributed networks 显示文摘 | Swamynathan G Zhao B Y Kevin C A | 2007 | Advances in Multimedia2007，2007，1： | 1 |
| 13 | Evolution of char chemistry, crystallinity, and ultrafme structure duringpulverized-coal combustion显示文摘 | KEVIN A D ROBERT H H NANCY Y Y THOMAS J H | 1995 | Combust Rame1995，100，12： | 1 |
| 14 | Origin and seed phenotype of maize low phytic acid 1-1 and low phytic acid 2-1显示文摘 | Raboy V Paola F G Kevin A Y | 2000 | Plant Physiol2000，124，： | 1 |
| 15 | Differential tumor surveillance by NK and NKT cells显示文摘 | MARK J S KEVIN Y R T SHAYNA E A S | 2000 | J Exp Med2000，191，4： | 1 |
| 16 | In-line coagulation with low-pressure membrane filtration 显示文摘 | Kevin Y C Brian A D | 2004 | Wat Res2004，38，19： | 1 |
| 17 | Differential tumor surveillance by NK and NKT cells显示文摘 | Mark J S Kevin Y R T Shayna E A S | 2000 | J Exp Med2000，191，4： | 1 |
| 18 | Workforce Configuration and Workflow Analysis of an Information Technology Organization:A Queueing Network Approach显示文摘 | Kevin Y K Ghanmi A Lam M N | 2002 | IEEE Transactions on Systems Man and Cybernetics-part A:Systems and Humans2002，32，6： | 1 |
| 19 | Hospitalizations for Cytomegalovirus Disease after Renal Transplantation in the United States显示文摘 | Kevin C Abbott Iman O Hypolite Rebecca Viola Ronald K Poropatich Paul Hshieh David Cruess Clifton A Hawkes Lawrence Y Agodoa | 2002 | Annals of Epidemiology2002，，6： | 1 |
| 20 | Workforce configuration and workflow analysis of an information technology organization: a queuing network approach 显示文摘 | Kevin Y K N Ghanmi A Lain N | 2002 | IEEE Transactions on Systems Man and Cybernetics (Part A: Systems and Humans)2002，32，6： | 1 |
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