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| 1 | IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass显示文摘Survival of children with chronic medical illnesses is leading to an increase in secondary osteoporosis due to impaired peak bone mass(PBM).Insulin-like growth factor type 1(IGF-1) levels correlate with the pattern of bone mass accrual and many chronic illnesses are associated with low IGF-1 levels.Reduced serum levels of IGF-1 minimally affect the integrity of the skeleton,whereas recent studies suggest that skeletal IGF-I regulates PBM.To determine the role of IGF-1 in postnatal bone mass accrual regardless of source,we established an inducible type 1 Igf receptor Cre/lox knockout mouse model,in which the type 1 Igf receptor was deleted inducibely in the mesenchymal stem cells(MSCs) from 3-7 weeks of age.The size of the mouse was not affected as knockout and wild type mice had similar body weights and nasoanal and femoral lengths.However,bone volume and trabecular bone thickness were decreased in the secondary spongiosa of female knockout mice relative to wild type controls,indicating that IGF-1 is critical for bone mass.IGF-1 signaling in MSCs in vitro has been implicated to be involved in both migration to the bone surface and differentiation into bone forming osteoblasts.To clarify the exact role of IGF-1 in bone,we found by immunohistochemical analysis that a similar number of Osterix-positive osteoprogenitors were on the bone perimeter,indicating migration of MSCs was not affected.Most importantly,56% fewer osteocalcin-positive mature osteoblasts were present on the bone perimeter in the secondary spongiosa in knockout mice versus wild type littermates.These in vivo data demonstrate that the primary role of skeletal IGF-1 is for the terminal differentiation of osteoprogenitors,but refute the role of IGF-1 in MSC migration in vivo.Additionally,these findings confirm that impaired IGF-1 signaling in bone MSCs is sufficient to impair bone mass acquisition. | Janet L. Crane Luo Zhao Joseph S. Frye Lingling Xian Tao Qiu Xu Cao | 2013 | Bone Research2013，1，2： | 8 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-α–Induced Cardiomyopathy显示文摘 | Yoshihiro Higuchi Charles F. McTiernan Carole B. Frye Brian S. McGowan Tung O. Chan Arthur M. Feldman | 2004 | Circulation: Journal of the American Heart Association2004，，15： | 2 |
| 4 | Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis显示文摘 | Kim B. Jensen Charlotte A. Collins Elisabete Nascimento David W. Tan Michaela Frye Satoshi Itami Fiona M. Watt | 2009 | Cell Stem Cell2009，，5： | 2 |
| 5 | Overexprcssion of tumor necrosis factor- alpha activites both anti and proapoptosis pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 2 |
| 6 | A Reporting System on Patients Evaluated for Coronary Artery Disease显示文摘 | W. GERALD AUSTEN JESSE E. EDWARDS ROBERT L. FRYE GOFFREDO G. GENSINI VINCENT L. GOTT LAWRENCE S. C. GRIFFITH DWIGHT C. MCGOON MARVIN L. MURPHY BENSON B. ROE | 1975 | Circulation1975，，4： | 2 |
| 7 | J Polym Sci显示文摘 | A H Frye R W Horst | 1960 | 45:11960，45，： | 2 |
| 8 | Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task显示文摘 | Frye CA Duffy CK Waif AA | 2007 | Neurobiol Learn Mem2007，88，： | 1 |
| 9 | The Invisible Hand and the Grabbing Hand 显示文摘 | Frye T Shleifer A | 1997 | The American Economic Review1997，87，2： | 1 |
| 10 | Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha显示文摘 | KUBOTA T MCTIEMAN C F FRYE C S | 1997 | Circ Res1997，81，： | 1 |
| 11 | Class II treatment in adults:com- paring camouflage orthodontics,dentofaeial orthopedics and orthog- nathie surgery-a cephalometrie study to evaluate various therapeutic effects显示文摘 | Kinzinger G Frye L Diedrich P | 2009 | J Orofac Orthop2009，70，1： | 1 |
| 12 | A randomized trial of therapies for type 2 diabetes and coronary artery disease显示文摘 | BARI 2D Study Group Frye RL August P | | New England Journal of Medicine0，，： | 1 |
| 13 | Incorporating simulators in a standardized patient exam显示文摘 | FRYE AW HOLDEN MD | 2002 | Academic Medicine2002，，7： | 1 |
| 14 | Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome显示文摘 | Diamond JR Ding G Frye J | 1992 | Am J Pathol1992，141，4： | 1 |
| 15 | Cardiac-specific overexpression of TNF-α causes lethal myocarditis in transgenic mice 显示文摘 | Kubota T Metieman C F~ Frye C S | 1997 | J Card Fail1997，3，2： | 1 |
| 16 | Tillage effects on sediment and solute nutrient losses from a Maury silt loam soil显示文摘 | Blevins R L Frye W W Baldwin P L | 1990 | Journal of Environmental Quality1990，19，： | 1 |
| 17 | Open-label aripiprazole in the treatment of acute bipolar depression : a prospective pilot trial显示文摘 | MCELROY SL SUPPES T FRYE MA | 2007 | J Affect Disord2007，101，13： | 1 |
| 18 | Overexpression of tumor necrosis factor - alpha activates both anti - and pro - apoptotic pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 19 | An Arabidopsis mutant with enhanced resistance to powdery mildew 显示文摘 | Frye C A Innes R W | 1998 | Plant cell1998，10，： | 1 |
| 20 | Comparison of typing results ob- tained for methicillin - resistant Staphylococcus aureus isolates with the DiversiLab system and pulsed - field gel electrophoresis 显示文摘 | Tenover FC Gay EA Frye S | 2009 | J Clin Microbiol2009，47，8： | 1 |
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