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| 1 | Anterior cruciate ligament reconstruction best practice: A review of graft choice显示文摘There is much literature about differing grafts used in anterior cruciate ligament(ACL) reconstruction. Much of this is of poor quality and of a low evidence base. We review and summarise the literature looking at the four main classes of grafts used in ACL reconstruction; bone-patella tendon-bone, hamstrings, allograft and synthetic grafts. Each graft has the evidence for its use reviewed and then compared, where possible, to the others. We conclude that although there is no clear 'best' graft, there are clear differences between the differing graft choices. Surgeon's need to be aware of the evidence behind these differences, in order to have appropriate discussions with their patients, so as to come to an informed choice of graft type to best suit each individual patient and their requirements. | Daniel A Shaerf Philip S Pastides Khaled M Sarraf Charles A Willis-Owen | 2014 | World Journal of Orthopedics2014，5，1： | 14 |
| 2 | Abdominal applications of diffusion-weighted magnetic resonance imaging: Where do we stand?显示文摘Diffusion-weighted imaging (DWI) is one of the magnetic resonance imaging (MRI) sequences providing qualitative as well as quantitative information at a cellular level. It has been widely used for various applications in the central nervous system. Over the past decade, various extracranial applications of DWI have been increasingly explored, as it may detect changes even before signal alterations or morphological abnormalities become apparent on other pulse sequences. Initial results from abdominal MRI applications are promising, particularly in oncological settings and for the detection of abscesses. The purpose of this article is to describe the clinically relevant basic concepts of DWI, techniques to perform abdominal DWI, its analysis and applications in abdominal visceral MR imaging, in addition to a brief overview of whole body DWI MRI. | Ajaykumar C Morani Khaled M Elsayes Peter S Liu William J Weadock Janio Szklaruk Jonathan Russell Dillman Asra Khan Thomas L Chenevert Hero K Hussain | 2013 | World Journal of Radiology2013，5，3： | 12 |
| 3 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 4 | Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies显示文摘Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators. | Khaled A Jadallah Susan M Kullab David S Sanders | 2014 | World Journal of Gastroenterology2014，20，27： | 9 |
| 5 | Study on the sensitivity to cadmium of marine fish Salaria basilisca(Pisces: Blennidae)显示文摘The present study tested the sensitivity of Salaria basilisca to water-cadmium (Cd) contamination. For this purpose, liver somatic index (LSI), Cd concentrations and the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in the liver of S. basilisca exposed to Cd-contaminated water (2 mg Cd/L as CdCl2) for 14 and 28 d. The results showed that the LSI decreased significantly after 14 and 28 d of Cd-exposure. Cd bioaccumulation in the liver resulted in an increasing uptake up to 42 μg/g dry weight after 28 d of exposure. Activities of CAT and SOD were significantly increased with increasing exposure time. A significant increase in GSH-Px activity, under Cd influence, was observed during 14-day exposure period (p < 0.0001). However, a significant decrease (p < 0.05) in this activity with respect to control fish was registered after 28 d of Cd-exposure. These results showed that Cd accumulation in the liver of S. basilisca could induce oxidative stress as demonstrated by changes in the antioxidant enzyme activities. Results also emphasized that S. basilisca may considered as a sensitive species to Cd exposure. | Imed Messaoudi Sana Barhoumi Khaled Sd Abdelhamid Kerken | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 6 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 7 | Ultrasonic strain imaging and reconstructive elastography for biological tissue 显示文摘 | Khaled W Reichling S Bruhns O T | 2006 | Ultrasonics2006，44，1： | 1 |
| 8 | Nevus lipomatosus cutaneous superficialis:report of eight cases显示文摘 | Goucha S Khaled A Zéglaoui F | 2011 | Dermatol Ther(Heidelb)2011，1，2： | 1 |
| 9 | Effects of feed contaminant deoxynivalenol on plas- ma cytokines and mRNA expression of immune genes in the intestine of broiler chickens 显示文摘 | KHALED G WAGEHA A A CHIMIDTSEREN S | 2014 | Plos One2014，9，71： | 1 |
| 10 | Nevus lipomatosus cutaneous superficialis: report of eight cases 显示文摘 | Goucha S Khaled A Zeglaoui F | 2011 | Dermatol Ther2011，1，2： | 1 |
| 11 | Knowledge representation object language on top of prolog显示文摘 | Khaled S | 1998 | Expert Systems with Applications1998，15，： | 1 |
| 12 | Surface modification of polypropylene films by chitosan and chitosan/pectin multilayer显示文摘 | Maher Z E Entsar S A Khaled S A | 2008 | Science direct Carbohydrate Polymers2008，，71： | 1 |
| 13 | Loss of PTEN expression as a prognostic marker for tongue cancer显示文摘 | Janet IL Jean-Charles S Khaled A H | 2001 | Arch Otolaryngol2001，127，14： | 1 |
| 14 | Elasto-plastic buckling of perforated plates under uniaxial compression 显示文摘 | Khaled M E Aly S N Mohammad I M | 2004 | Thin-Walled Structures2004，42，： | 1 |
| 15 | Effects of zinc supplementation on blood rheology during excrcise显示文摘 | Khaled S Brun JF Cassanas G | | 0，，： | 1 |
| 16 | Parametric Productivity Measurement and Choice among Flexible Functional Forms 显示文摘 | Berndt E R Khaled M S | 1979 | Journal of Politi- cal Economy1979，87，： | 1 |
| 17 | The r-Dominance: anew dominance relation for interactive evolutionarymultivriteria decision making显示文摘 | LAMJED B S SLIM B KHALED G | 2010 | IEEE Transactions onEvolutionary Computation2010，4，5： | 1 |
| 18 | Effect of fiber-reinforced polymer wraps on corrosion activity and concrete cracking in chloride contaminated concrete cylinders显示文摘 | TAMER E M ALI C KHALED S | 2006 | Journal of Composites tbr Construction2006，10，2： | 1 |
| 19 | Bond behavior of corroded steel reinforcement in concrete wraps with carbon fiber reinforced polymer sheets显示文摘 | KHALED S TED S | 2003 | Journal of Materials in Civil Engineering2003，15，4： | 1 |
| 20 | Clustering sentence-level text using a novel fuzzy, relational clustering algorithm 显示文摘 | ANDREW S KHALED A | 2013 | IEEE Transactions on Knowledge and Data Engineering2013，25，1： | 1 |
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