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| 1 | Outcomes of liver transplantation in patients with hepatorenal syndrome显示文摘Hepatorenal syndrome(HRS) plays an important role in patients with liver cirrhosis on the wait list for liver transplantation(LT). The 1 and 5-year probability of developing HRS in cirrhotic with ascites is 20% and 40%, respectively. In this article, we reviewed current concepts in HRS pathophysiology, guidelines for HRS diagnosis, effective treatment options presently available, and controversies surrounding liver alone vs simultaneous liver kidney transplant(SLKT) in transplant candidates. Many treatment options including albumin, vasoconstrictors, renal replacement therapy, and eventual LT have remained a mainstay in the treatment of HRS. Unfortunately, even after aggressive measures such as terlipressin use, the rate of recovery is less than 50% of patients. Moreover, current SLKT guidelines include:(1) estimation of glomerular filtration rate of 30 m L/min or less for 4-8 wk;(2) proteinuria > 2 g/d; or(3) biopsy proven interstitial fibrosis or glomerulosclerosis. Even with these updated criteria there is a lack of consistency regarding longterm benefits for SLKT vs LT alone. Finally, in regards to kidney dysfunction in the post-transplant setting, an estimation of glomerular filtration rate < 60 mL /min per 1.73 m2 may be associated with an increased risk of patients having long-term end stage renal disease. HRS is common in patients with cirrhosis and those on liver transplant waitlist. Prompt identification and therapy initiation in transplant candidates with HRS may improve post-transplantation outcomes. Future studies identifying optimal vasoconstrictor regimens, alternative therapies, and factors predictive of response to therapy are needed. The appropriate use of SLKT in patients with HRS remains controversial and requires further evidence by the transplant community. | Rohan M Modi Nishi Patel Sherif N Metwally Khalid Mumtaz | 2016 | World Journal of Hepatology2016，8，24： | 8 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | Primary graft dysfunction after liver transplantation: From pathogenesis to prevention显示文摘 | Khalid I Bzeizi Rajiv Jalan John N Plevris Peter C Hayes | 2003 | Liver Transpl2003，，2： | 2 |
| 4 | Medical research during the COVID-19 pandemic显示文摘The current pandemic of coronavirus disease 2019(COVID-19)which was first detected in Wuhan,China in December 2019 is caused by the novel coronavirus named severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).The virus has quickly spread to a large number of countries leading to a great number of deaths.Unfortunately,till today there is no specific treatment or vaccination for SARS-CoV-2.Most of the suggested treatment medications are based on in vitro laboratory investigations,experimental animal models,or previous clinical experience in treating similar viruses such as SARS-CoV-1 or other retroviral infections.The running of any clinical trial during a pandemic is affected at multiple levels.Reasons for this include patient hesitancy or inability to continue investigative treatments due to self-isolation/quarantine,or limited access to public places(including hospitals).Additional barriers relate to health care professionals being committed to other critical tasks or quarantining themselves due to contact with COVID-19 positive patients.The best research approaches are those that adapt to such external unplanned obstacles.Ongoing clinical trials before COVID-19 pandemic have the potential for identifying important therapies in the long-term if they can be completed as planned.However,these clinical trials may require modifications due a pandemic such as this one to ensure the rights,safety,and wellbeing of participants as well as medical staff involved in the conduction of clinical trials.Clinical trials initiated during the pandemic must be time-efficient and flexible due to high contagiousness of severe acute respiratory syndrome coronavirus 2,the significant number of reported deaths,and time constraints needed to perform high quality clinical trials,enrolling adequate sample sizes.Collaboration between different countries as well as implementation of innovative clinical trial designs are essential to successfully complete such initiatives during the current pandemic.Studies looking at the long term sequalae of COVID-19 are also of importance as recent publications describe multi-organ involvement.Long term follow-up of COVID-19 survivors is thus also important to identify possible physical and mental health sequellae. | Khalid AlNaamani Siham AlSinani Alan N Barkun | 2020 | World Journal of Clinical Cases2020，8，15： | 2 |
| 5 | Inter-ethnic marriages and severity of coronary artery disease:A multicenter study of Arabian Gulf States显示文摘AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD. | Amin Daoulah Salem Al-kaabi Amir Lotfi Mushabab Al-Murayeh S Ali Nasseri Waleed Ahmed Salah N Al-Otaibi Mohamed N Alama Osama E Elkhateeb Amy J Plotkin Majed M Malak Khalid Alshali Mohamed Hamzi Saleh Al Khunein Mohammed Abufayyah Alawi A Alsheikh-Ali | 2017 | World Journal of Cardiology2017，9，4： | 2 |
| 6 | Evaluation of compliance and outco-mes of a management protocol for massive postpartum hemorrhage at a tertiary care hospital in Pakistan显示文摘 | Sheikh L Najmi N Khalid U | 2011 | BMC Pregnancy Childbirth2011，11，： | 1 |
| 7 | Concomitant bilateral testicular epidermoid cysts显示文摘 | Khalid M Malik N Salauddin M A | 2008 | Saudi Mect J2008，29，6： | 1 |
| 8 | Single-stranded linear amplification protocol results in reproducible and reliable microarray data from nanogram amounts of starting RNA显示文摘 | STIREWALT DL POGOSOVA-AGADJANYAN EL KHALID N | 2004 | Genomics2004，83，2： | 1 |
| 9 | Core competence for sustainable competitive advantage 显示文摘 | Khalid H Zhang Y Malak N | 2002 | IEEE Transactions on Engineering Management2002，49，1： | 1 |
| 10 | Diagnostic accuracy of Magnetic Resonance Imaging in assessment of Meniscal and ACL tear:Cor- relation with arthroscopy显示文摘 | Yaqoob J Alam MS Khalid N | 2015 | Pak J Med Sci2015，31，2： | 1 |
| 11 | Follicular dendritic cell sarcoma of lymph node-a rare entity显示文摘 | Khalid S Yaqoob N Pervez S | 2006 | J Pak Med Assoc2006，56，3： | 1 |
| 12 | Strain localization in sand: plane versus triaxial compression显示文摘 | Khalid A Susan N Stein F | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，6： | 1 |
| 13 | Immunohis to chemical analysis of p53 and p21 in human primary glioblastomas in relation to proliferative potential and atpttosis显示文摘 | Khalid M H Yagi N Hiura T | 1998 | Brain Tumour Pathol1998，15，2： | 1 |
| 14 | Long-term quality of life measures after functional endoscopic sinus surgery 显示文摘 | KHALID A N QURAISHI S A KENNEDY D W | 2004 | Am J Rhinol2004，18，3： | 1 |
| 15 | Using multi-agent architecture in FMS for dynamic scheduling显示文摘 | KHALID K HENRI P MEBARKI N | 1997 | Journal of Intelligent Manufacturing1997，16，8： | 1 |
| 16 | Core competence for sustainable competitive advantage: a structured methodology for identifying core competence 显示文摘 | Khalid H Zhang Y Malak N | 2002 | IEEE Transactions on Engineering Management2002，49，1： | 1 |
| 17 | Peripheral vascular disease显示文摘 | Bajwa TK Shaler YA Gupta A Khalid MA Moussavi N | 1998 | Curr Probl Cardiol1998，23，： | 1 |
| 18 | Synthesis, color fastness evaluation and utilization of humic acid derived dyes/pigment 显示文摘 | SAQIB N TAHIRA B KHALID M | 2011 | J Chil Chem Soc2011，56，1： | 1 |
| 19 | Concomitant bilateral testicular epidermoid cysts显示文摘 | Khalid M Malik N Salauddin MA Rashid M | | 0，，06： | 1 |
| 20 | Germination potential of chickpeas under saline conditions显示文摘 | Khalid M N Iqbal H F Tahir A | 2001 | Pakistan Journal of Biological Sciences2001，4，4： | 1 |
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