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| 1 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 2 | Preliminary investigation on the antibacterial activity of mango(Mangifera indica L:Anacardiaceae) seed kernel显示文摘Objective:To evaluate the antibacterial activity of the methanolic extract of mango(Mangifera indica L) seed kernel.Methods:Chokanan mango seed kernel and seed kernels from assorted mango varieties were collected,cleaned,dried and powered.Crude methanolic extracts of mango seed kernel were analyzed for the phytochemical constituents.The free radical scavenging activity was determined by 2,2-Diphenyl-1-picrylhydrazyl(DPPH) assay.Antibacterial activity was evaluated by disc diffusion assay with three medically important bacterial pathogens such as methicillin resistant Staphylococcus aureus(S.aureus)(MRSA),Escherichia coli(E.coli) and Vibrio vulnificus(V.vulnificus).Results:Qualitative phytochemical analysis indicated the presence of important phytochemical compounds such as glycosides,saponins,flavanoids, tannins and alkaloids.There was no significant difference in the phytochemical content between the single and assorted mango seed kernels.However,the free radical scavenging study indicated that the assorted mango kernels showed slighdy higher activity than the single species(P<0.05). The crude methanolic extract of mango seed kernel at a concentration of 100 mg/mL is found to have potential antimicrobial activity against MRSA and E.coli compared to V.vulnificus. Study on the antibacterial activity also indicated that there was no significant difference in the antibacterial activity of the single and assorted mango seed kernel extracts.Conclusions:The present study conclusively demonstrates the free radical scavenging activity and antibacterial activities of mango seed kernel.In addition,the results also indicated that there is no significant difference in the phytochemical content and biological activity of mango kernels from single and assorted mango varieties. | Jasminder Kaur Xavier Rathinam Marimuthu Kasi Khoo Miew Leng Rajasekaran Ayyalu Kathiresan S Sreeramanan Subramaniam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 11 |
| 3 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 4 | Vegetation and Environment History for the Past 14 000 yr BP from Dingnan, Jiangxi Province, South China显示文摘迟了的 Pleistocene-Holocene 花粉,磷,和炭记录在南部的中国在南部的江西省从 peatland 被重建。今天的区域与米饭稻,蔬菜,和水果统治的村庄,小镇,和农业有一处多山、滚动的风景第二等的森林和松重新植林的花园,以及区域。记录在 14 300 年 BP 前开,与统治沼泽地区域的 Alnus 树林并且与包围斜坡上的开的 Quercus 树林。森林区域从约 12 800 年 BP 变得更复杂并且从 9 000 年 BP 进一步。在约 6 000 年 BP,有变清的证据,由 45004000 年 BP,在沼泽地 Alnus 和陆上的森林的完全的倒塌作为低区域被变换成米饭生产。为许多记录,在这个地点附近的火的出现是低的,尽管有地区性的火的证据。火在变清被用作一个工具然后在残株在米饭收获以后烧的年度周期使用了。营养素铺平,在沉积由全部的磷思考了似乎是仔细,与在表面的森林变化和高价值有关,层可能源于与农业联系的陆地管理技术。因此,人的影响极大地改变了森林盖子,火频率,和滋养的动力学;这为约 6 000 年 BP 是明显的然后加强向现代。 | John Richard Dodson Shirene Hickson Rachel Khoo Xiao-Qiang Li Jemina Toia Wei-Jian Zhou | 2006 | Journal of Integrative Plant Biology2006，48，9： | 7 |
| 5 | 外源过氧化氢处理对采后荔枝褐变及活性氧代谢的影响显示文摘【目的】研究外源过氧化氢(H_(2)O_(2))处理对采后荔枝褐变及活性氧代谢的影响,为荔枝采后保鲜提供途径,以期提高果实的贮藏品质。【方法】以清水处理为对照(CK),采用不同浓度(1、5和10 mmol/L)的外源H_(2)O_(2)浸泡荔枝3 min,在4℃下冷藏放置,每隔3 d取样一次,进行失重率、褐变指数、丙二醛(MDA)含量、细胞膜透性、内源H_(2)O_(2)含量、超氧阴离子(O_(2)-)产生速率、多酚氧化酶(PPO)活性和超氧化物歧化酶(SOD)活性等生理指标的测定。【结果】不同浓度的外源H_(2)O_(2)处理对采后荔枝会产生不同的贮藏效果。以5 mmol/L外源H_(2)O_(2)处理保鲜效果最佳,明显降低果皮中MDA含量、内源H_(2)O_(2)含量和PPO活性,并提高SOD活性,减缓O_(2)-产生速率。至贮藏末期(12 d),经5 mmol/L外源H_(2)O_(2)处理的采后荔枝SOD活性较CK显著提高31.41%(P<0.05,下同),MDA含量、PPO活性、O_(2)-产生速率和内源H_(2)O_(2)含量较CK分别降低44.72%、38.72%、22.63%和13.75%,其失重率、褐变指数和相对电导率最低。1 mmol/L外源H_(2)O_(2)处理效果稍逊于5 mmol/L外源H_(2)O_(2)处理,而经10 mmol/L外源H_(2)O_(2)处理显著提高采后荔枝的MDA和内源H_(2)O_(2)含量,加速采后果实衰老。【结论】采用5 mmol/L外源H_(2)O_(2)处理可调节采后荔枝的活性氧代谢而延缓其衰老进程,为H_(2)O_(2)应用于采后荔枝保鲜提供理论支撑。 | 潘家丽 覃子倚 李静 Khoo Hock Eng 董新红 | 2022 | 南方农业学报2022，53，5： | 6 |
| 6 | Spark-generated bubble collapse near or inside a circular aperture and the ensuing vortex ring and droplet formation显示文摘This paper aims to study the oscillation of a sparkgenerated submerged bubble located near or inside a circular aperture made in a flat plate using high-speed visualization technique. In the case of a bubble oscillating near an aperture the initial free surface of the water was set at the bottom surface of the plate. The efects of aperture size and bubblefree surface distance on the bubble behavior as well as on the ensuing droplet dynamics are investigated. It was found that the direction of the bubble reentrant jet was towards the aperture or away from it respectively when the normalized aperture size was smaller or greater than a certain critical value. In addition, a toroidal vortex ring was observed to form, which rotated inwards as it moved away from the aperture. It was also found that if the bubble was incepted at a distance sufciently away from a supercritical size aperture a single droplet could be produced. In the case of a bubble initiated in the middle of a circular aperture submerged just beneath the water free surface, the bubble was found to take the shape of an ellipsoid during its expansion. Then a reentrant jet was initiated and pierced the bubble from its top side. | Abdolrahman Dadvand Mazyar Dawoodian Boo Cheong Khoo Reza Esmaily | 2013 | Acta Mechanica Sinica2013，29，5： | 6 |
| 7 | Indication of lower neck irradiation in nasopharyngeal carcinoma without nodal metastasis: the potential impact of tumor volume显示文摘 | FU Jie ZHOU Jia-yin Vincent FH CHONG James BK Khoo | 2013 | Chinese Medical Journal2013，，11： | 5 |
| 8 | 经皮置入式腰椎棘突间撑开器的生物力学测试显示文摘目的:评价经皮置入式腰椎棘突间撑开器对置入节段及其邻近节段活动度的影响。方法:选取6具新鲜人体腰椎标本(L1~L5),剔除附着肌肉,保留各韧带及骨骼,将标本的头尾端固定在MTS生物力学试验测试机上,对标本施加400N的轴向压力,然后以0.5°/s速度施加六个方向(前屈/后伸、左右侧屈、左右轴向旋转)±7.5Nm的力矩,测量L2/3、L3/4节段各个运动方向的运动范围(ROM,完整状态组);于L3/4节段置入Bullet棘突间撑开器,按照同样方法测试标本各个方向的活动度(置入撑开器组)。测试后以2Hz频率循环加载,屈伸20 000次、侧屈15 000次、旋转5 000次,摄X线片观察内置物位置及棘突有无骨折,肉眼观察内置物有无变形和破损。结果:L3/4节段完整状态下前屈和后伸的平均ROM值分别为4.62°±2.26°和4.07°±1.92°,置入撑开器后前屈和后伸的平均ROM值分别为3.87°±2.06°和2.57°±2.06°,两组比较差异有统计学意义(P<0.05);两组侧方屈曲和旋转的平均ROM值差异均无统计学意义。在完整状态和置入撑开器后L2/3节段各个运动方向的平均ROM值差异均无统计学意义。循环加载至预定加载次数后X线片示撑开器无移位,棘突无骨折;未发现棘突撑开装置变形或出现裂缝。结论:经皮置入式棘突间撑开器能够使置入节段前屈和后伸的活动度明显减少,但轴向旋转和侧向弯曲不受影响,且对邻近上位节段的活动度无影响。 | 张加芳 郑召民 张奎渤 刘辉 吕维加 胡勇 Larry Khoo | 2011 | 中国脊柱脊髓杂志2011，21，2： | 5 |
| 9 | Soil Bulk Density Estimation Methods: A Review显示文摘Measurement of soil bulk density is important for understanding the physical, chemical, and biological properties of soil. Accurate and rapid soil bulk density measurement techniques play a significant role in agricultural experimental research. This review is a comprehensive summary of existing measurement methods and evaluates their advantages, disadvantages, potential sources of error,and directions for future development. These techniques can be broadly categorised as direct and indirect methods. Direct methods include core, clod, and excavation sampling, whereas indirect methods include the radiation and regression approaches. The core method is most widely used, but it is time consuming and difficult to use for sampling multiple soil depths. The size of the coring cylinder used, operator experience, sampling depth, and in-situ soil moisture content significantly affect its accuracy. The clod method is suitable for use with heavy clay soils, and its accuracy is dependent on equipment calibration, drying time, and operator experience, but the process is complicated and time consuming. Excavation techniques are most commonly used to evaluate the bulk density of forest soils, but have major limitations as they cannot be used in soils with large pores and their measurement accuracy is strongly influenced by soil texture and the type of analysis selected. The indirect methods appear to have greater accuracy than direct approaches, but have higher costs, are more complex, and require greater operator experience. One such approach uses gamma radiation, and its accuracy is strongly influenced by soil depth. Regression methods are economical as they can make indirect measurements, but these depend on good, quality data of soil texture and organic matter content and geographical and climatic properties. Also, like most of the other approaches, its accuracy decreases with sampling depth. | Ahmed Abed Gatea AL-SHAMMARY Abbas Z.KOUZANI Akif KAYNAK Sui Yang KHOO Michael NORTON Will GATES | 2018 | Pedosphere2018，28，4： | 5 |
| 10 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 11 | 用传统分类法、叙词表编制机构Taxonomy的实证研究显示文摘Information Studies Taxonomy的编制以新加坡南洋理工大学黄金辉传播与信息学院信息学系为实施机构,以杜威法和三部叙词表为结构库和词库,调查了杜威法和三部叙词表作为机构Taxonomy构建资源的充分性及其在主题分面编制中的作用,同时探讨了用传统分类法和叙词表编制机构Taxonomy类表的步骤与方法。该研究虽然在英文语境下进行,但所运用的思路与方法对于中文环境下机构Taxonomy的编制也是有借鉴意义的,其研究方法与研究结论对于在中文环境下用传统分类法、叙词表编制机构Taxonomy的研究也有推动作用。表2。参考文献7。 | 王忠红 Abdus Sattar Chaudhry Khoo Christopher | 2008 | 中国图书馆学报2008，34，6： | 4 |
| 12 | Simulations of Compressible Two-Medium Flow by Runge-Kutta Discontinuous Galerkin Methods with the Ghost Fluid Method显示文摘The original ghost fluid method (GFM) developed in [13] and the modifiedGFM (MGFM) in [26] have provided a simple and yet flexible way to treat twomediumflow problems. The original GFM and MGFM make the material interface'invisible' during computations and the calculations are carried out as for a singlemedium such that its extension to multi-dimensions becomes fairly straightforward.The Runge-Kutta discontinuous Galerkin (RKDG) method for solving hyperbolic conservationlaws is a high order accurate finite element method employing the usefulfeatures from high resolution finite volume schemes, such as the exact or approximateRiemann solvers, TVD Runge-Kutta time discretizations, and limiters. In this paper,we investigate using RKDG finite element methods for two-medium flow simulationsin one and two dimensions in which the moving material interfaces is treated via nonconservativemethods based on the original GFM and MGFM. Numerical results forboth gas-gas and gas-water flows are provided to show the characteristic behaviors ofthese combinations. | Jianxian Qiu Tiegang Liu Boo Cheong Khoo | 2008 | Communications in Computational Physics2008，3，2： | 4 |
| 13 | 去卵巢老年大鼠软骨退变与E_2、MMP-13、TNF-α的相关性显示文摘目的探讨去卵巢老年大鼠雌激素下降与软骨退变的相关性。方法 24只6月龄雌性SD大鼠按数字表法随机分为对照组、去卵巢组和去卵巢+跑步组各8只。对照组常规饲养,去卵巢组行双侧卵巢切除术,去卵巢+跑步组行双侧卵巢切除术合并疲劳训练。5周后处死,取左侧膝关节石蜡包埋,行HE染色、免疫组化分析、膝关节软骨Mankin评分,右侧膝关节抽取关节液检测TNF-α含量,取血清检测E_2含量。结果 (1)膝关节切片HE染色显示:与对照组比较,去卵巢组与去卵巢+跑步组膝关节软骨均出现缺损,其中去卵巢+跑步组缺损最重;(2)与对照组比较,去卵巢组和去卵巢+跑步组mankin评分、膝关节MMP-13表达、关节液TNF-α浓度均明显提高(P<0.01),血清E_2浓度明显降低(P<0.01),且以去卵巢+跑步组变化最为显著。结论老年大鼠雌激素的下降与软骨退变具有一定的相关性。 | KHOO YEW LEE 周逸 张俐 | 2018 | 福建中医药2018，49，2： | 3 |
| 14 | Atomic layer deposition enabling higher efficiency solar cells:A review显示文摘Atomic layer deposition(ALD)can synthesise materials with atomic-scale precision.The ability to tune the material composition,film thickness with excellent conformality,allow low-temperature processing,and in-situ real-time monitoring makes this technique very appealing for a wide range of applications.In this review,we focus on the application of ALD layers in a wide range of solar cells.We focus on industrial silicon,thin film,organic and quantum dot solar cells.It is shown that the merits of ALD have already been exploited in a wide range of solar cells at the lab scale and that ALD is already applied in high-volume manufacturing of silicon solar cells. | MdAnower Hossain Kean Thong Khoo Xin Cui Geedhika K Poduval Tian Zhang Xiang Li Wei Min Li Bram Hoex | 2020 | Nano Materials Science2020，2，3： | 3 |
| 15 | Investigation of Turbulent Transition in Plane Couette Flows Using Energy Gradient Method显示文摘The energy gradient method has been proposed with the aim of better understanding the mechanism of flow transition from laminar flow to turbulent flow.In this method,it is demonstrated that the transition to turbulence depends on the relative magnitudes of the transverse gradient of the total mechanical energy which amplifies the disturbance and the energy loss from viscous friction which damps the disturbance,for given imposed disturbance.For a given flow geometry and fluid properties,when the maximum of the function K(a function standing for the ratio of the gradient of total mechanical energy in the transverse direction to the rate of energy loss due to viscous friction in the streamwise direction)in the flow field is larger than a certain critical value,it is expected that instability would occur for some initial disturbances.In this paper,using the energy gradient analysis,the equation for calculating the energy gradient function K for plane Couette flow is derived.The result indicates that K reaches the maximum at the moving walls.Thus,the fluid layer near the moving wall is the most dangerous position to generate initial oscillation at sufficient high Re for given same level of normalized perturbation in the domain.The critical value of K at turbulent transition,which is observed from experiments,is about 370 for plane Couette flow when two walls move in opposite directions(anti-symmetry).This value is about the same as that for plane Poiseuille flow and pipe Poiseuille flow(385-389).Therefore,it is concluded that the critical value of K at turbulent transition is about 370-389 for wall-bounded parallel shear flows which include both pressure(symmetrical case)and shear driven flows(anti-symmetrical case). | Hua-Shu Dou Boo Cheong Khoo | 2011 | Advances in Applied Mathematics and Mechanics2011，3，2： | 3 |
| 16 | Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study显示文摘 | Yahya Shehabi Lucy Chan Suhaini Kadiman Anita Alias Wan Nasrudin Ismail Mohd Ali T. Ismail Tan Tien Meng Khoo Saedah Binti Ali Mat Ariffin Saman Ahmad Shaltut Cheng Cheng Tan Cow Yen Yong Michael Bailey | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 17 | 推拿配合整脊治疗椎动脉型颈椎病的研究概况显示文摘颈椎是人体脊柱活动量最大的关节,纤维环的松弛与颈椎间盘的退变失稳造成颈椎在特定空间及时间范围内发生异常。颈部的肌肉拉伸或收缩持续时间过久容易导致损伤,损伤的软组织使椎体的整体生理曲度改变或小错位而导致颈椎病。其中,椎动脉型颈椎病是颈椎退行性改变后,椎骨内外平衡失稳并压迫. | KHOO YEW LEE 周逸敏 张俐 | 2019 | 福建中医药2019，50，1： | 3 |
| 18 | 中药治疗湿热蕴结型痛风性关节炎研究现状显示文摘痛风是人体嘌呤代谢紊乱、超负荷而导致尿酸盐结晶形成并沉积于皮下、关节、骨骼等而引发局部急、慢性炎症和组织损伤的一种常见病变,其与高尿酸血症直接相关[1]。中医认为该病是因为湿热蕴结于关节处导致其无法排出而发病[2]。饮食过度、肥甘厚腻的生活方式,导致痛风发病率逐渐递增,痛风病患者的生活质量下降[3]。《中医病证诊断疗效标准》中将痛风分为湿热蕴结型、肝肾阴虚型、痰浊阻滞型、瘀热阻滞型4型[4], | KHOO YEW LEE 周逸敏 张俐 | 2018 | 福建中医药2018，49，1： | 3 |
| 19 | Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole 显示文摘 | Shen DH Khoo US Ngan HY | 2003 | Arch Pathol Lab Med2003，127，： | 2 |
| 20 | The Modified Ghost Fluid Method Applied to Fluid-Elastic Structure Interaction显示文摘In this work,the modified ghost fluid method is developed to deal with 2D compressible fluid interacting with elastic solid in an Euler-Lagrange coupled system.In applying the modified Ghost Fluid Method to treat the fluid-elastic solid coupling,the Navier equations for elastic solid are cast into a system similar to the Euler equations but in Lagrangian coordinates.Furthermore,to take into account the influence of material deformation and nonlinear wave interaction at the interface,an Euler-Lagrange Riemann problem is constructed and solved approximately along the normal direction of the interface to predict the interfacial status and then define the ghost fluid and ghost solid states.Numerical tests are presented to verify the resultant method. | Tiegang Liu A.W.Chowdhury Boo Cheong Khoo | 2011 | Advances in Applied Mathematics and Mechanics2011，3，5： | 2 |
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