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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | Preparation of ZrO2 coated graphite powders 显示文摘 | SUNWOO S KIM J H LEE K G | 2000 | J Mater Sci2000，35，14： | 2 |
| 4 | A potential based panel method for the analysis of a two-dimensional super or partially cavitating hydrofoil 显示文摘 | LEE C S KIM Y G LEE J T | 1992 | J of Ship Res1992，36，2： | 2 |
| 5 | 显示文摘 | Jang G H Hong S J Kim D K | 2000 | IEEE Transactions On Magnetics2000，36，5： | 2 |
| 6 | Improved serpentine laminating micromixer with enhanced local advection显示文摘 | PARK J M KIM D S KANG T G | 2008 | Microfluidics and Nanofluidics2008，4，6： | 1 |
| 7 | Experiment and simulation on the performance of an autocascade refrigeration system using carbon dioxide as a refrigerant 显示文摘 | Kim S G Kim M S | 2002 | International Journal of Refrigeration2002，25，11： | 1 |
| 8 | Salt tolerance study in Zoysiagrass显示文摘 | Lee G J Yoo Y K Kim K S | 1994 | Horticulture Science1994，35，3： | 1 |
| 9 | Antiviral effect of ingenol and gingerol during HIV-1 replication in MT4 human T lymphocytes显示文摘 | LEE H S KIM S S KIM G J | 2008 | Antiviral Research2008，78，2： | 1 |
| 10 | A novel transcription factor, T- bet, directs Thl lineage commitement显示文摘 | SZABO S J KIM S T COSTA G L | 2000 | Cell2000，100，6： | 1 |
| 11 | Aciraetobacterpneumonia:a review显示文摘 | Hartzell J D Kim A S Kortepeter M G | 2007 | Med Gen Med2007，9，3： | 1 |
| 12 | Hydrogen-reduction behavior and microstructural characteristics of WO3-CuO powder mixtures with various milling time显示文摘 | Oh S T Jeon H | 2003 | Journal of Alloys and Compounds2003，，354： | 1 |
| 13 | Development of a new photocurable composite resin with reduced curing shrinkage显示文摘 | Kim J G Kim M S | 2002 | Dent Mater2002，18，： | 1 |
| 14 | Random sequence analy-sis of genomie DNA of a hyperthemophile:Aquifex pyrophilus显示文摘 | Kim S S Ryu J R | 1997 | Extremophiles1997，1，3： | 1 |
| 15 | Stochastic volatility:likelihood inference and eomparison with ARCH models显示文摘 | Shephard N G Chib S | 1998 | Review of Economic Studies1998，65，： | 1 |
| 16 | A Decomposition of Total Frontier Factor Productivity Growth in Korean Manufacturing Industries显示文摘 | HAN G | 2001 | Journal of Productivity2001，16，3： | 1 |
| 17 | Inactivation of DFR (Dihydroflavonol 4-reductase) gene transcription results in blockage of anthocyanin production in yellow onions (Allium cepa)显示文摘 | KIM S G BINZEL M L PARK S H YOO K S PIKE L M | 2004 | Molecular Breeding2004，14，： | 1 |
| 18 | Series compensated step-down AC voltage regulator using AC chopper with transformer 显示文摘 | Ryoo H J Kim J S Kim G H | 2003 | Electrical Machines and Systems2003，，： | 1 |
| 19 | Generalized selection combining based on the log-likelihood ratio显示文摘 | Kim S W Kim Y G and Simon M K | 2004 | IEEE Transactions on Communications2004，52，4： | 1 |
| 20 | Behavior of double skin composite wall subjected to in- plane cyclic loading显示文摘 | Eom T S Park H G Lee C H Kim J H Chang I H | 2009 | Journal of Structural Engineering ASCE2009，135，10： | 1 |
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