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| 1 | Genetic epidemiology of primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants,however,remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However,according to strict criteria for what may be denominated a susceptibility gene in complex diseases,no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC,as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). | Tom H Karlsen Erik Schrumpf Kirsten Muri Boberg | 2007 | World Journal of Gastroenterology2007，13，41： | 7 |
| 2 | Autoantibodies in primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. | Johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 3 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 4 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 5 | Hydroxyethyl Starch Reduces Coagulation Competence and Increases Blood Loss During Major Surgery: Results From a Randomized Controlled Trial显示文摘 | Kirsten C. Rasmussen P?r I. Johansson Michael H?jskov Irina Kridina Thomas Kistorp Peter Thind Henning B. Nielsen Birgitte Ruhnau Tom Pedersen Niels H. Secher | 2014 | Annals of Surgery2014，，2： | 2 |
| 6 | Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder显示文摘 | HEYNS C F KOCK D E KIRSTEN P H | 1991 | J Urol1991，145，2： | 1 |
| 7 | Health, well-being and wellness: An anthropological eco-systemic approach显示文摘 | Kirsten T G van der Walt H J Viljoen C T | 2009 | Jour nal of Interdisciplinary Health Sciences2009，14，1： | 1 |
| 8 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 9 | Examining the association between cigarette smoking and eolorectal cancer using historical case-control data 显示文摘 | Luke JP Andrew H Kirsten BM | 2009 | Cancer Epidemiol2009，33，34： | 1 |
| 10 | The metabolic syndrome in patients with chronic bronchitis and COPD frequency and associated Consequences for systemic inflammation and physical inactivity显示文摘 | Watz H Waschki B Kirsten A | 2009 | Chest2009，136，4： | 1 |
| 11 | Expectant management of early onest severe pre - eclampsia perinatal outcome 显示文摘 | Hall DR Odendaal H J Kirsten GF | 2000 | BJOG2000，107，： | 1 |
| 12 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 13 | Expectant management of early onset, severe pre-eclampsia: perinatal outcome 显示文摘 | Hall DR Odendaal H J Kirsten GF | 2000 | Br J Obstet Gynaecol2000，107，： | 1 |
| 14 | Comparison of scoring methods for the detection of causal genes with or without rare variants 显示文摘 | Scholz M Kirsten H | 2011 | BMC Proc2011，59，： | 1 |
| 15 | Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum 显示文摘 | KIRSTEN A L FEDERICA M YOUNG H C et a l | 2009 | Plant Physiology2009，150，3： | 1 |
| 16 | Circulating microRNAsre-merging biomarkers for diagnosis and prognosis in patientswith gastrointestinal cancers显示文摘 | Kirsten L Joerg H Zhe W | 2015 | Clin Sci2015，128，1： | 1 |
| 17 | Thermal degradation of betacyanins in juices from purple pitaya monitored by high-performance liquid chromatography-tandem mass spectometric analyses 显示文摘 | Kirsten M H Florian C S Reinhold C | 2004 | Eur Food Res Technol2004，219，： | 1 |
| 18 | Effects of processing and storage on juice colour and betacyanin stability of purple pitaya (Hylocereus polyrhizus) juice 显示文摘 | Kirsten M H Christine M Florian C S | 2007 | Eur Food Res Technol2007，224，： | 1 |
| 19 | Expectant management of early onset, severe pre-eclampsia: Perinatal outcome 显示文摘 | Hall D R Odendaal H J Kirsten G F | 2000 | Br J Obstet Gynecol2000，107，10： | 1 |
| 20 | Expectant management of early onset,severe pre-eclampsia:perinatal outcome 显示文摘 | HALL D R ODENDAAL H J KIRSTEN G F | 2000 | Br J Obstet Gynecol2000，107，10： | 1 |
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