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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Deep structure beneath the southwestern section of the Longmenshan fault zone and seimogenetic context of the 4.20 Lushan M_S7.0 earthquake显示文摘Magnetotelluric measurements were carried out along two profiles across the middle and southwestern sections of the Longmenshan fault zone(LMSf)from 2009 to 2011,after the 2008 Wenchuan MW7.9 earthquake.The former profile crosses the Wenchuan event epicenter and the latter one crosses 2013 Lushan MS7.0 event epicenter.The data were analyzed using advanced processing techniques,including phase tensor and two-dimensional inversion methods,in order to obtain reliable 2-D profiles of the electrical structure in the vicinity of the two earthquakes.A comparison of the two profiles indicates both similarities and differences in the deep crustal structure of the LMSf.West of the southwestern section,a crustal high conductivity layer(HCL)is present at about 10 km depth below the Songpan-Garzêblock;this is about 10 km shallower than that under the middle section of the LMSf.A high resistivity body(HRB)is observed beneath the southwestern section,extending from the near surface to the top of upper mantle.It has a smaller size than the HRB observed below the middle section.In the middle section,there is a local area of decreased resistivity within the HRB but there is absence of this area.The 2013 Lushan earthquake occurred close to the eastern boundary of HRB and the Shuangshi-Dachuan fault,of which the seismogenic context has both common and different features in comparison with the 2008 Wenchuan event.On a large scale,the 2013 Lushan earthquake is associated with the HCL and deformation in the crust including HCL of the eastern Tibetan Plateau.In order to assess seismic risk,it is important to consider both the stress state and the detailed crustal structure in different parts of the LMSf. | ZHAN Yan ZHAO GuoZe UNSWORTH Martyn WANG LiFeng CHEN XiaoBin LI Tao XIAO QiBin WANG JiJun TANG Ji CAI JunTao WANG YanZhao | 2013 | Chinese Science Bulletin2013，58，28： | 39 |
| 3 | Salient object detection: A survey显示文摘Detecting and segmenting salient objects from natural scenes, often referred to as salient object detection, has attracted great interest in computer vision. While many models have been proposed and several applications have emerged, a deep understanding of achievements and issues remains lacking. We aim to provide a comprehensive review of recent progress in salient object detection and situate this field among other closely related areas such as generic scene segmentation, object proposal generation, and saliency for fixation prediction. Covering 228 publications, we survey i) roots, key concepts, and tasks, ii) core techniques and main modeling trends, and iii) datasets and evaluation metrics for salient object detection. We also discuss open problems such as evaluation metrics and dataset bias in model performance, and suggest future research directions. | Ali Borji Ming-Ming Cheng Qibin Hou Huaizu Jiang Jia Li | 2019 | Computational Visual Media2019，5，2： | 40 |
| 4 | A nomogramfor predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis显示文摘Background:Low-grade endometrial stromal sarcoma(LG-ESS)is a rare tumor that lacks a prognostic prediction model.Our study aimed to develop a nomogram to predict overall survival of LG-ESS patients.Methods:A total of 1172 patients confirmed to have LG-ESS between 1988 and 2015 were selected from the Surveillance,Epidemiology and End Results(SEER)database.They were further divided into a training cohort and a validation cohort.The Akaike information criterion was used to select variables for the nomogram.The discrimination and calibration of the nomogram were evaluated using concordance index(C-index),area under time-dependent receiver operating characteristic curve(time-dependent AUC),and calibration plots.The net benefits of the nomogram at different threshold probabilities were quantified and compared with those of the International Federation of Gynecology and Obstetrics(FIGO)criteria-based tumor staging using decision curve analysis(DCA).Net reclassification index(NRI)and integrated discrimination improvement(IDI)were also used to compare the nomogram’s clinical utilitywith that of the FIGO criteria-based tumor staging.The risk stratifications of the nomogram and the FIGO criteria-based tumor staging were compared.Results:Seven variables were selected to establish the nomogram for LG-ESS.The C-index(0.814 for the training cohort and 0.837 for the validation cohort)and the time-dependent AUC(>0.7)indicated satisfactory discriminative ability of the nomogram.The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts.The NRI values(training cohort:0.271 for 5-year and 0.433 for 10-year OS prediction;validation cohort:0.310 for 5-year and 0.383 for 10-year OS prediction)and IDI(training cohort:0.146 for 5-year and 0.185 for 10-year OS prediction;validation cohort:0.177 for 5-year and 0.191 for 10-year OS prediction)indicated that the established nomogram performed significantly better than the FIGO criteria-based tumor staging alone(P<0.05).Furthermore,DCA showed that the nomogram was clinically useful and had better discriminative ability to recognize patients at high risk than the FIGO criteria-based tumor staging.Conclusions:A prognostic nomogram was developed and validated to assist clinicians in evaluating prognosis of LG-ESS patients. | Jie Wu Huibo Zhang Lan Li Mengxue Hu Liang Chen Bin Xu Qibin Song | 2020 | Cancer Communications2020，40，7： | 35 |
| 5 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 6 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 7 | Uncertainty analyses on the calculation of water environmental capacity by an innovative holistic method and its application to the Dongjiang River显示文摘The estimation and allocation of water environmental capacity(WEC) are essential to water quality management and social–economic interests. However, there is inevitable uncertainty in the capacity estimation due to model conceptualization, data collection and parameter calibration. An innovative holistic approach was developed, which took both independence and relevance between parameters into account to analyze the uncertainties in WEC calculation and estimate the margin of safety. The Dongjiang River was taken as the case to demonstrate the method, focusing on the chemical oxygen demand and NH4+–N that were the two major water quality problems in the river. The results showed that the proposed holistic approach is very promising and applicable compared to traditional methods of uncertainty analysis. | Qiuwen Chen Qibin Wang Zhijie Li Ruonan Li | 2014 | Journal of Environmental Sciences2014，26，9： | 9 |
| 8 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 9 | Formation of willow leaf-like structures composed of NH2-MIL68(In) on a multifunctional multiwalled carbon nanotube backbone for enhanced photocatalytic reduction of Cr(VI)显示文摘photogenerated 电子 / 洞以及提高的可见轻吸收的有效分离和转移在 photocatalytic 反应起必要作用。支持 Cr (VI ) 的 photocatalytic 减小,一个有毒的重金属离子, multiwalled 碳 nanotube (MWCNT ) 作为一个电子领受人被介绍进 NH 2-MIL-68(In) 。这导致了一棵柳树的生长形成 MWCNT/NH 2-MIL-68(In)(PL-1 ) 的一根 MWCNT 脊梁上的像叶子的金属器官的框架(MOF ) ,它显示出 photogenerated 搬运人的高度有效的转移。而且, MWCNT 加入为 Cr (VI ) 散开介绍了更多的 mesopores 并且没有降低传导乐队位置,提高了可见轻吸附。作为结果, PL-1 的运动常数被发现是几乎三的 photocatalytic 比父母 NH 2-MIL-68(In) 的高预定。因此,在 MWCNT 上种 MOF 由利用太阳能为环境污染的有效补习提供一个灵巧、有希望的答案。这个工作提供为 photocatalytic 反应使用 MWCNT/MOF composites 的第一个例子。 | Yunhong Pi Xiyi Li Qibin Xia Junliang Wu Zhong Li Yingwei Li Jing Xiao | 2017 | Nano Research2017，10，10： | 5 |
| 10 | A novel lead-free Na_(0.5)Bi_(0.5)TiO_(3)-based ceramic with superior comprehensive energy storage and discharge properties for dielectric capacitor applications显示文摘Na_(0.5)Bi_(0.5)TiO_(3)(NBT)-based ceramics have been widely used as dielectric materials for energy storage capacitors because of their environmental friendliness and excellent ferroelectric properties.However,their energy storage performance still needs to be further improved to satisfy the increasing demand.Herein,we report a novel 0.90(Na_(0.5)Bi_(0.5))0.7Sr_(0.3)TiO_(3-0.10)Bi(Ni_(0.5)Sn_(0.5))O_(3)(0.90NBST-0.10BNS)ceramic with significantly improved energy density(5.0 J cm3),enhanced recoverable energy density(4.18 J cm^(3))and high energy efficiency(83.64%)through the incorporation of Bi(Ni0.5Sn0.5)O3(BNS),due to the increased breakdown strength and the relaxation ferroelectric(RFE)properties.The first-order reversal curve(FORC)measurements confirm that the addition of BNS improves RFE properties by breaking the order of long-range ferroelectricity.The 0.90NBST-0.10BNS ceramic also possesses an outstanding temperature and frequency stability of energy storage properties in the range of 20C e140C and 1 Hze100 Hz,respectively.More importantly,the discharge properties characterized by a preeminent power density(36.19 MW cm^(3)),transient energy release times(144.2 ns),and high discharge energy density(1.16 J cm3)also synchronously observed in 0.90NBST-0.10BNS ceramic.These results show that the 0.90NBST-0.10BNS ceramic with outstanding comprehensive performances is a promising energy storage ceramic candidate for capacitors in high power systems. | Da Li Ying Lin Qibin Yuan Miao Zhang Liang Ma Haibo Yang | 2020 | Journal of Materiomics2020，6，4： | 4 |
| 11 | Effect of externally applied Jidesheng anti-venom on skin and soft-tissue necrosis after Chinese cobra bite: a retrospective study显示文摘OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite. | Quanfang Chen Wei Wang Qibin Li Yulong Bai Xiaoying Zou Yanbin Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
| 12 | Flexible mica films for high-temperature energy storage显示文摘Dielectrics used for energy storage are highly desired for power electronics and pulse power applications and the polymer capacitors are the main commercial ones available.The development of flexible electronics and wearable devices require the relative materials being flexible.Besides,high temperature resistance is also desired because of the rising demand for high power devices and large electricity under elevated temperature.The polymer dielectrics for polymer capacitors are flexible but with relatively low working temperature normally less than 100℃.Therefore,fabricating a dielectric material to satisfy the flexibility and high working temperature simultaneously is still a great challenge.Here we propose one solution by demonstrating a hand-exfoliated fluorophlogopite film with micrometer scale thickness.Among which,the mica film with a thickness of around 10μm(Mica-10)exhibits the inorganic-like temperature stability even polymer-like flexibility.From 25℃to 200℃,Mica-10 has an energy density of around 11.27 J/cm^(3)with a variation within 2%,accompanied by a charge-discharge efficiency of around 95%at an electric field of 500 MV/m.Meanwhile,the thin thickness makes Mica-10 flexible,enabling its excellent flexibility and durability.This work revives the traditional material,mica,providing a way for high-temperature energy storage applications. | Xinwei Xu Wenlong Liu Yi Li Yifei Wang Qibin Yuan Jie Chen Rong Ma Feng Xiang Hong Wang | 2018 | Journal of Materiomics2018，4，3： | 3 |
| 13 | Modulation of evening complex activity enables north-to-south adaptation of soybean显示文摘Soybean,a typical short-day crop,is sensitive to photoperiod,which is a major limiting factor defining its north-to-south cultivation range.The long-juvenile(LJ)trait is controlled primarily by the J locus which has been used for decades by soybean breeders to delay flowering and improve grain yield in tropical regions.The J gene encodes an ortholog of the Arabidopsis Evening Complex(EC)component EARLY FLOWERING 3(ELF3).To identify modifiers of J,we conducted a forward genetic screen and isolated a mutant(eoj57)that in combination with j has longer flowering delay compared with j single mutant plants.Map-based cloning and genome re-sequencing identified eoj57(designated as GmLUX2)as an ortholog of the Arabidopsis EC component LUX ARRHYTHMO(LUX).To validate that GmLUX2 is a modifier of J,we used trans-complementation and identified a natural variant allele with a similar phenotype.We also show that GmLUX2 physically interacts with GmELF3a/b and binds DNA,whereas the mutant and natural variant are attenuated in both activities.Transcriptome analysis shows that the GmLUX2-GmELF3a complex co-regulates the expression of several circadian clock-associated genes and directly represses E1 expression.These results provide mechanistic insight into how GmLUX2-GmELF3 controls flowering time via synergistic regulation of gene expression.These novel insights expand our understanding of the regulation of the EC complex,and facilitate the development of soybean varieties adapted for growth at lower latitudes. | Xiaolong Fang Yapeng Han Mengshi Liu Jiacan Jiang Xiang Li Qichao Lian Xianrong Xie Yian Huang Qibin Ma Hai Nian Ji Qi Cunyi Yang Yingxiang Wang | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 14 | Multidimensional clinical data denoising via Bayesian CP factorization显示文摘CANDECOMP/PARAFAC(CP) tensor factorization is an efficient technique for incomplete tensor-data processing through capturing the multilinear latent factors. Based on the incorporate a sparsity-inducing prior over multiple latent factors and appropriate hyper-priors over all hyper-parameters, a Bayesian-based hierarchical probabilistic CP factorization model could be formed. By this way, the rank of the incomplete tensor can be determined automatically. In this paper, we explored the tensor completion method in processing incomplete multidimensional electroencephalogram(EEG) and magnetic resonance imaging(MRI) clinical data. The empirical results indicated that the Bayesian CP tensor factorization of incomplete data method can effectively recover EEG signal with missing data and denoised the noisy MRI data. | CUI GaoChao ZHU Li GUI LiHua ZHAO QiBin ZHANG JianHai CAO JianTing | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 15 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 16 | Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis显示文摘Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment. | Zhenxing Gao Min Peng Liang Chen Xiaowen Yang Huan Li Run Shi Guiru Wu Lili Cai Qibin Song Chaoyang Li | 2019 | Virologica Sinica2019，34，2： | 2 |
| 17 | Synergistic effects of Mg-substitution and particle size of chicken eggshells on hydrothermal synthesis of biphasic calcium phosphate nanocrystals显示文摘Magnesium(Mg^2+))ion plays important roles in biomineralization of bone,teeth and calcium carbonate skeletons.Herein,chicken eggshells mainly comprising of Mg-calcite nanocrystals(Mg/(Mg+Ca)2.0 mol.%)were used to fabricate biphasic calcium phosphate(BCP),a mixture of hydroxyapatite(HA)and p-tricalcium phosphate(p-TCP)nanocrystals,through hydrothermal reactions at 200℃for 24 h.Our results indicated thatβ-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite,while HA nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal system.Mg substitution in calcite resulted in formation ofβ-TCP nanocrystals instead of HA crystals through ion-exchange reactions.BCP samples with different compositions(28.6-77.8 wt.%β-TCP)were produced by controlling particle sizes of eggshells for hydrothermal reactions.The larger particles lead to the larger proportion ofβ-TCP in the BCP composition.Therefore,Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation reactions.Cell culture results showed that the BCP products were non-cytotoxic to MC3 T3-E1 cells,which may be used for bone substitute materials in future. | Wei Cui Qibin Song Huhu Su Zhiqing Yang Rui Yang Na Li Xing Zhang | 2020 | Journal of Materials Science & Technology2020，36，1： | 2 |
| 18 | Photo-Isomerization Energy Storage Using Azobenzene and Nanoscale Templates: A Topical Review显示文摘Azobenzene(AZO) has attached tremendous attention in the field of photo-isomerization energy storage due to its advantages of absorbing light in ultraviolet-visible range and reversible isomerization. However, the issues of low energy density and short half-lifetime restrict the further development of AZO. Therefore, a method, by preparing hybrid photo-isomerization energy storage materials using nanoscale templates, was proposed to handle the above two issues. In this paper, a summary of hybrid photo-isomerization energy storage materials with AZO and nanoscale templates is conducted from the aspects of templates, preparation methods, derivatives and applications. The performances of template candidates, i.e. carbon nanotubes(CNTs) and graphene(GO) are reviewed and compared based on the analysis of grafting density, energy density, and half-lifetime of hybrid materials. Then, two major preparation methods of AZO hybrid materials including non-covalent and covalent functionalizations are discussed. Furthermore, the studies on AZO derivatives functionalized on nanoscale templates are summarized to further point to the direction of derivatization towards high performance AZO-functionalized materials. Finally, due to the superiority of AZO hybrid solid-state films in large-scale utilization, their current applications are reviewed to find out some promising applications. | LI Shuwei WANG Hongqiang FANG Juan LIU Qibin WANG Jiangjiang GUO Shaopeng | 2020 | Journal of Thermal Science2020，29，2： | 2 |
| 19 | Molecular Dynamics Simulation of Sulphur Nucleation in S-H2S System 显示文摘 | Li Qibin Liu Chao Chen Xi | 2014 | Molecular Physics2014，112，7： | 1 |
| 20 | A simulation model for the temperature field in bioceramic coating cladded by wide-band laser显示文摘 | Zhu Weidong Liu Qibin Li Haitao | 2007 | Materials & Design2007，28，10： | 1 |
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