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| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Comparison of intracellular localization of Nubpl and Nubp2 using GFP fusion proteins显示文摘 | Okuno T Yamabayashi H Kogure K | 2010 | Mol Biol Rep2010，37，3： | 1 |
| 3 | Induction of jun-like immunoreactivity in astrocytes in gerbil hippocampus with ischemic tolerance显示文摘 | KatoH Kogure K Araki T | 1995 | Neurosci Lett1995，189，1： | 1 |
| 4 | Stacking structures in pyrophyllite revealed by high-resolution transmission electron microscopy(HRTEM)显示文摘 | Kogure T Jige M Kameda J Yamagishi A Miyawaki R Kitagawa R | | 0，，8： | 1 |
| 5 | Molecular and hischemical events within the brain subjected to cerebral ischemia显示文摘 | KOGURE T KOGURE K | 1997 | Clin Neurosci1997，4，4： | 1 |
| 6 | MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer 显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 7 | Molecularand biochemicai events with in the brain subjected to cerebra lischemia显示文摘 | Kogure T KogureK | 1997 | Clin Neurosci1997，4，4： | 1 |
| 8 | Effects of Addition of Poly( ethylene glycol) on the Formation of An- atase Nanocrystals in SiO2-TIO2 Gel Films with Hot Water Treatment显示文摘 | KOTANI Y MATSUDA A KOGURE T | 2001 | Chemistry of Materials2001，13，6： | 1 |
| 9 | microRNA-29 canregulate expression of the long non-coding RNA gene MEG3 inhepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 10 | Formation of Anatase Nanoerystals-Preeipitated Silica Coatings on Plastic Substrates by the Sol-Gel Process with Hot Water Treatment 显示文摘 | Matsuda A Matoda T Kogure T | 2003 | Journal of Sol-Gel Science and Technology2003，27，1： | 1 |
| 11 | Autoimmune responses to proliferating cell nuclear antigen multiprotein complexes involved in cell proliferation are strongly associated with their structure and biologic function in patients with systemic lupus erythematosus显示文摘 | Kogure T Takasaki Y Takeuchi K | 2002 | Arthritis Rheum2002，46，11： | 1 |
| 12 | Plastic deformation of pure silicon nanocrystals by molecular dynamics 显示文摘 | DOYAMA M NOZAKI T KOGURE Y | 1999 | Nanostructured Materials1999，12，： | 1 |
| 13 | microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 14 | Intercellular Nanovesicle-Medi- ated microRNA transfer: a mechanism of environmental modula- tion of hepatocellular cancer cell growth显示文摘 | Kogure T Lin WL Yan IK | 2011 | Hepatology2011，54，4： | 1 |
| 15 | Long-term changes in gerbil neurotransmitter receptors following transient cerebral ischemia显示文摘 | Araki T Kato H Kogure K Kanai Y | 1992 | Br J Pharmacol1992，107，3： | 1 |
| 16 | miR -221 silencing blocks hepatocellular carcinoma and promotes survival显示文摘 | PARK J K KOGURE T NUOVO G J | 2011 | Cancer Res2011，71，24： | 1 |
| 17 | Autoimmune responses to proliferating cell nuclear antigen multiprotein complexes involved in cell proliferation are strongly associated with their structure and biologic function in patients with systemic lupus erythematosus显示文摘 | Kogure T Takasaki Y Takeuchi K | 2002 | Arthritis Rheum2002，46，11： | 1 |
| 18 | Intercellular nanovesiclemediat- ed microRNA transfer:a mechanism of environmental modulation of hepatocellular cancer cell growth 显示文摘 | Kogure T Lin WL Yah IK | 2011 | Hepatology2011，54，4： | 1 |
| 19 | microRNA-29 can regulateexpression of the long non-coding RNA gene MEG3 inhepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 20 | Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT显示文摘 | Kogure D Matsuda H Ohnishi T | 2000 | J Nucl Med2000，41，7： | 1 |
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