|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intrauterine growth restriction alters growth performance, plasma hormones,and small intestinal microbial communities in growing-finishing pigs显示文摘Background: The interaction of the gut microbiota with key metabolic and physiological processes may be associated with poor growth outcomes in animals born with intrauterine growth restriction(IUGR).Results: Growth performance, plasma hormone concentrations, and intestinal microbiota composition were analyzed in IUGR pigs and in normal birth weight(NBW) pigs when the NBW pigs reached 25, 50, and 100 kg of body weight(BW). Compared to NBW pigs, IUGR pigs had lower initial, weaned, and final BW, and lower average daily gain and average daily feed intake in all the considered time points. In the 25 kg BW group, IUGR pigs had higher concentrations of plasma ghrelin and pancreatic polypeptide(PP), but lower insulin concentration than NBW pigs, while the situation was reversed in the 50 kg BW group. As compared to NBW pigs, IUGR pigs had higher microbial alpha diversity in the jejunum and ileum;in the 50 and 100 kg BW groups, IUGR pigs had higher Firmicutes abundance but lower Proteobacteria abundance in the jejunum, and lower Lactobacillus abundance in the jejunum and ileum;in the 25 kg BW group, IUGR pigs showed higher unclassified Ruminococcaceae abundance in the ileum;and in 25 and 50 kg BW groups, IUGR pigs showed lower Ochrobactrum abundance in the jejunum.Spearman's correlation revealed that Lactobacillus was negatively correlated with growth performance, while unclassified Ruminococcaceae was positively correlated. Predictive metagenomic analysis detected significantly different expression of genes in the intestinal microbiota between IUGR and NBW pigs, suggesting different metabolic capabilities between the two groups.Conclusions: Growing-finishing IUGR pigs showed lower growth performance, higher microbial alpha diversity, and differences in plasma hormone concentrations compared to NBW pigs. Alterations in the abundance of Firmicutes,Proteobacteria, Ruminococcaceae, Lactobacillus, and Ochrobactrum in the small intestine may be associated with IUGR, and may therefore serve as a future target for gut microbiota intervention in growing-finishing IUGR pigs. | Liang Xiong Jinming You Wanghong Zhang Qian Zhu Francois Blachier Yulong Yin Xiangfeng Kong | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 5 |
| 2 | Enhanced wetting and properties of carbon/carbon-Cu composites with Cr_3C_2 coatings by Cr-solution immersion method显示文摘A facile ammonium-dichromate solution immersion method was introduced to synthesize the copperwettable Cr_3C_2 coating on and inside the carbon-carbon(C/C) preform. The formation mechanism and the microstructures of the Cr_3C_2 coatings were studied. The contact angle between molten copper and the C/C decreased from 140? to 60?, demonstrating the significant improvement in the wettability. The Cr_3C_2-coated C/C-Cu composite with only 4.2% porosity and 3.69 g cm^(-3) density was manufactured through copper infiltration. As a result, the thermal and electrical conductivity of the modified C/C-Cu increased significantly due to the infiltrated copper. Also the mechanical properties of the composites including both the flexural and compressive strengths were enhanced by over 100%. The modified C/C-Cu composite exhibited lower friction coefficients and wear rates for different load levels than those of the commercial C/Cu composite. These results demonstrate the potential of the modified C/C-Cu material for use in electrical contacts. | Bo Kong Jinming Ru Hongdi Zhang Tongxiang Fan | 2018 | Journal of Materials Science & Technology2018，34，3： | 4 |
| 3 | Incorporation of circulating tumor cells and whole-body metabolic tumor volume of 18F-FDG PET/CT improves prediction of outcome inⅢB stage small-cell lung cancer显示文摘Objective: We investigated the correlation between the number of circulating tumor cells(CTCs) and wholebody metabolic tumor volume(WBMTV) measured by 18 F-fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT).The aim was to evaluate the value of the incorporation of CTC number and WBMTV in the prognostic prediction of stage III small-cell lung cancer(SCLC).Methods: One hundred and twenty-nine patients were enrolled in this study.All patients were treated with four cycles of a platinum-based regimen and concurrent chest irradiation,followed by prophylactic cranial irradiation.Blood samples for CTC analysis were obtained from 112 patients before the initiation of chemotherapy(as a baseline),after cycle 1 and after cycle 4.CTCs were measured using the CELLSEARCH? system.The patients underwent pretreatment FDG PET/CT WBMTV,which included all malignant lesions.The Spearman rank test was used to determine the correlation among CTC counts,WBMTV and disease stage.Overall survival(OS) and progression-free survival(PFS) curves were produced using the Kaplan-Meier method,and survival differences between groups were assessed by the log-rank test.Results: The number of CTCs at baseline did not correlate with WBMTV before the initiation of therapy(P=0.241).The number of CTCs at baseline and the WBMTV before the initiation of therapy were independent relevant factors for PFS and OS.The subgroup analysis(Group A: CTC count >19.5 and a WBMTV >266.5cm^3;Group B: CTC count >19.5 and a WBMTV ≤266.5cm^3; Group C: CTC count ≤19.5 and a WBMTV >266.5cm^3;Group D: CTC count ≤19.5 and a WBMTV ≤266.5cm^3) showed that the differences were statistically significant in the median PFS(Group A vs.D,P<0.001; Group B vs.D,P=0.018; Group C vs.D,P=0.029) and in the median OS(Group A vs.D,P<0.001; Group B vs.D,P=0.012).Conclusions: CTC number and WBMTV are related to progression and death in patients with SCLC.The incorporation of CTC number and WBMTV scans can provide a detailed prognostic prediction for SCLC. | Lei Fu Ying Zhu Wang Jing Dong Guo Li Kong Jinming Yu | 2018 | Chinese Journal of Cancer Research2018，30，6： | 3 |
| 4 | Polysaecharide templated silver nanowire for ultrasensitive electrical detection of nucleic acids显示文摘 | KONG Jinming FERHAN A R CHEN Xiantong | 2008 | Analytical Chemistry2008，80，： | 1 |
| 5 | Modeling the Warming Impact of Urban Land Expansion on Hot Weather Using the Weather Research and Forecasting Model: A Case Study of Beijing, China显示文摘The impacts of three periods of urban land expansion during 1990–2010 on near-surface air temperature in summer in Beijing were simulated in this study, and then the interrelation between heat waves and urban warming was assessed. We ran the sensitivity tests using the mesoscale Weather Research and Forecasting model coupled with a single urban canopy model,as well as high-resolution land cover data. The warming area expanded approximately at the same scale as the urban land expansion. The average regional warming induced by urban expansion increased but the warming speed declined slightly during 2000–2010. The smallest warming occurred at noon and then increased gradually in the afternoon before peaking at around 2000 LST—the time of sunset. In the daytime, urban warming was primarily caused by the decrease in latent heat flux at the urban surface. Urbanization led to more ground heat flux during the day and then more release at night, which resulted in nocturnal warming. Urban warming at night was higher than that in the day, although the nighttime increment in sensible heat flux was smaller. This was because the shallower planetary boundary layer at night reduced the release efficiency of near-surface heat. The simulated results also suggested that heat waves or high temperature weather enhanced urban warming intensity at night. Heat waves caused more heat to be stored in the surface during the day, greater heat released at night, and thus higher nighttime warming. Our results demonstrate a positive feedback effect between urban warming and heat waves in urban areas. | Xiaojuan LIU Guangjin TIAN Jinming FENG Bingran MA Jun WANG Lingqiang KONG | 2018 | Advances in Atmospheric Sciences2018，35，6： | 1 |
| 6 | Analysis and biological activities of aothocyanins显示文摘 | KONG Jinming CHIA L S GOH N K | 2003 | Phytochemistry2003，64，5： | 1 |
| 7 | Analysis and biological activities of anthocyanins显示文摘 | KONG Jinming CHI L S GOH N K | 2003 | Phytochemistry2003，64，5： | 1 |
| 8 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 9 | Analysis and biologicalactivities of anthocyanins显示文摘 | KONG Jinming CHIA L S GOH N K | 2003 | Phytochemistry2003，64，5： | 1 |
| 10 | Analysis and biological activities of anthocyanins显示文摘 | KONG Jinming CHIA L S GOH N K | 2003 | Phytochemistry2003，64，： | 1 |
| 11 | Analysis and biological activities of anthocyanins显示文摘 | KONG Jinming CHIA L S GOH N K | 2003 | Phytochemistry2003，，64： | 1 |
| 12 | Using 18 F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus显示文摘 | Xiaojun Zhong Jinming Yu Baijiang Zhang Dianbin Mu Weidi Zhang Daotang Li Anqin Han Pingping Song Hui Li Guoren Yang Feng-Ming Kong Zheng Fu | 2009 | International Journal of Radiation Oncology Biology Physics2009，，1： | 1 |
| 13 | Analysis and biological activities of anthocyanins 显示文摘 | KONG JINMING CHIA L S GOH N K | 2003 | Phytochemistry2003，，64： | 1 |
| 14 | DNA-templated preparation of palladium nanoparticles and their application显示文摘 | FANG Cheng FAN Yi KONG Jinming | 2007 | Sens Actuators:B2007，126，2： | 1 |
| 15 | Synthesis of a Heptapeptide and Its Application in the Detection of Mercury(Ⅱ) Ion显示文摘A new heptapeptide, Cys-Pro-Gly-Cys-Pro-Gly-Cys-CONH2(P7), was prepared via Fmoc solid-phasepepfide synthesis, purified by high performance liquid chromatography(HPLC) and characterized by mass spectro-metry(MS). The interactions of P7 with metal ions were also investigated by spectroscopy and the results show thatP7 has highly selective binding affinity to Hg(Ⅱ). Based on this specific character, a simple, rapid and sensitivedetection method for Hg(Ⅱ) was developed. When the mixture solution of P7 and Hg(Ⅱ) was added to colloidal goldnanoparticles(GNP), the color of GNP remained unchanged. On the contrary, the color of GNP changed from red toblue when the mixture solutions of P7 and other metal ions were added. | FENG Huiyun GAO Lei YE Xinhui WANG Lei XUE Zechun KONG Jinming LI Lianzhi | 2017 | Chemical Research in Chinese Universities2017，33，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员