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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | WO3 nanoparticles on MCM - 48 as a highly selective and versatile heterogeneous catalyst for the oxidation of olefins, sulfides, and cyclic ketones显示文摘 | Koo D H Kim M Chang S | 2005 | Organic Letters2005，7，22： | 1 |
| 3 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
| 4 | Synthesis of B-C-N nanotubes by means of gas arc discharge with a rotating anode显示文摘 | Kim C S Jeong S M Koo W H | 2004 | Mater Lett2004，58，2223： | 1 |
| 5 | Production of lactic acid from paper sludge by simultaneous saccharification and fermentation 显示文摘 | Lee S M Koo Y M Lin J | 2004 | Ad- vances in Biochemical Engineering/Biotechnology2004，87，： | 1 |
| 6 | Tonsillectomy as a treatment for psoriasis: a review显示文摘 | Wu W Debbaneh M Moslehi H Koo J Liao W | 2014 | The Journal of dermatological treat- ment2014，25，6： | 1 |
| 7 | Assessment of myocardial viability in reperfused acute myocardial infarction using 16- slice computed tomography in comparison tomagnetic resonance imaging显示文摘 | Mahnken AH Koos R Katoh M | 2005 | J Am Coll Cardiol2005，45，12： | 1 |
| 8 | Effect of the experimental parameters on the structure of nitrogen-doped carbon nanotubes produced by aerosol chemical vapour deposition 显示文摘 | Koos A A Dowling M Jurkschat K | 2009 | Carbon2009，47，1： | 1 |
| 9 | The prophylactic use of tranexamic acid and aprotinin in orthotopic liver trans- plantation: a comparative study显示文摘 | Dalmau A Sabate A Koo M | 2004 | Liver Transpl2004，10，2： | 1 |
| 10 | HyPocholesterolemic effects of Chinese tea显示文摘 | Yang T T Koo M W | 1997 | Pharmacol Res1997，35，6： | 1 |
| 11 | Cost-effectiveness and efficiency of shockwave lithotripsy vs flexible ureteroscopic holrnium:yttrium-alumiu- lure-garnet laser lithotripsy in the treatment of lower pole renal calculi 显示文摘 | Koo V Young M Thompson T | 2011 | B J U Int2011，108，： | 1 |
| 12 | Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects显示文摘 | Koo J M Kleinstreuer C | 2003 | Journal of Micromechanics and Microengineering2003，13，： | 1 |
| 13 | Vessel/mooring/riser coupled dynamic analysis of a turret-moored FPSO compared with OTRC experiment显示文摘 | Kim M H Koo B J Mercier R M | 2005 | Ocean Engineering2005，32，： | 1 |
| 14 | On neighbor-selection strategy in hybrid peer-to-peer networks显示文摘 | Simon G M Koo Karthik Kannan C S George Lee | 2006 | Future Generation Computer Systems2006，22，： | 1 |
| 15 | Effect of Water Tempera- ture on Survival, Growth and Intermoh Period of Tiger Crab, Orithyia sinica (Linnaeus)Larvae显示文摘 | Koo J G Jee J h Kim J M et ol | 2004 | Journal of Fish Pat holo- gy2004，17，2： | 1 |
| 16 | Contact stress transients during functional loading of ankle stepoff incongruities 显示文摘 | McKinley T O Rudert M J Koos D C | 2006 | J Biomech2006，39，4： | 1 |
| 17 | Modeling of typical microbial cell growth in batch culture 显示文摘 | Lin J Q Lee S M Koo Y M | 2000 | Biotechnol Bioprocess Eng2000，5，： | 1 |
| 18 | Synthesis and characterization of maleated polyethylene/clay nanocomposites显示文摘 | Wang K H Choi M H Koo C M | 2001 | Polymer2001，42，： | 1 |
| 19 | Determination of the constitu- ents of honey by near-infrared spectroscopy 显示文摘 | HA J KOO M OK H | 1998 | Jour- nal of Near Infrared Spectroscopy1998，6，1： | 1 |
| 20 | Effect of group music activity as an ad- junctive therapy on psychotic symptoms in patients with acute schizophrenia 显示文摘 | Peng SM Koo M Kuo JC | 2010 | Arch Psychiatr Nurs2010，24，6： | 1 |
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