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| 1 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Multifaceted nature of membrane microdomains in colorectal cancer显示文摘Membrane microdomains or lipid rafts are known to be highly dynamic and to act as selective signal transduction mediators that facilitate interactions between the cell's external and internal environments.Lipid rafts play an important mediating role in the biology of cancer:they have been found in almost all existing experimental cancer models,including colorectal cancer (CRC),and play key regulatory roles in cell migration,metastasis,cell survival and tumor progression.This paper explores the current state of knowledge in this field by highlighting some of the pioneering and recent lipid raft studies performed on different CRC cell lines and human tissue samples.From this literature review,it becomes clear that membrane microdomains appear to be implicated in all key intracellular signaling pathways for lipid metabolism,drug resistance,cell adhesion,cell death,cell proliferation and many other processes in CRC.All signal transduction pathways seem to originate directly from those peculiar lipid islands,thereby orchestrating the colon cancer cells' state and fate.As confirmed by recent animal and preclinical studies in different CRC models,continuing to unravel the structure and function of lipid rafts-including their associated complex signaling pathways-will likely bring us one step closer to better monitoring and treating of colon cancer patients. | Kristina A Jahn Filip Braet | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 3 | Gastric hyperplastic polyps causing upper gastrointestinal hemorrhage in a young adult显示文摘Here, we report a case of a young man who presented with a significant upper gastrointestinal bleed treated by endoscopic removal of multiple hyperplastic polyps. Gastric hyperplastic polyps are a relatively uncommon cause of overt gastrointestinal bleeding. While most hyperplastic gastric polyps are asymptomatic, they may present with abdominal pain, iron def iciency anemia or gastric outlet obstruction. These polyps are associated with conditions such as Helicobacter pylori gastritis and atrophic autoimmune gastritis, which predispose the epithelium to chronic inf lammation and epithelial repair.The patient presented to Northwestern Memorial Hospital in July 2011. The polyps were resected by clip-assisted snare polypectomy. Histopathologic assessment of the resected polyps demonstrated multiple, nonulcerative hyperplastic polyps measuring 1.3-1.8 cm in size, without evidence of dysplasia or malignancy. This case describes a young adult patient with multiple, large gastric polyps causing overt gastrointestinal bleeding. This is a rare presentation in a young individual, as these polyps are typically identifi ed in patients older than 60 years of age and less commonly, pediatric populations. | Brian J Secemsky Kenika R Robinson Kumar Krishnan Kristina A Matkowskyj Barbara H Jung | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 4 | Radiation-induced epigenetic DNA methylation modification of radiation-response pathways显示文摘 | Deborah A Antwih Kristina M Gabbara Wayne D Lancaster Douglas M Ruden Steven P Zielske | 2013 | Epigenetics2013，，8： | 1 |
| 5 | Quantitative immunohistochemistry by measuring cumulative signal strength using commercially available software photoshop and matlab 显示文摘 | Kristina A Matkowskyja B Dan Schonfeldc SA | 2000 | J Histochem Cytochem2000，48，5： | 1 |
| 6 | Applications of acupuncture to women's health 显示文摘 | Kristina A Nassim A | 2001 | Prim Care Update Ob/Gyns2001，8，6： | 1 |
| 7 | BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma显示文摘 | Kristina M B Rebecca A B Laurence L | 2003 | Clinical Cancer Research2003，9，3： | 1 |
| 8 | ,The Effects of Ethidium Bromide Induced Loss of Mitochondrial DNA on Mitochondrial Phenotype and Ultrastructure in a Human Leukemia T-cell Line (MOLT-4 cells)显示文摘 | Ray Armand Jacqueline Y Kristina A | 2004 | Toxicology and Applied Pharmacology2004，196，： | 1 |
| 9 | Response of bone and periodontal ligament cells to biodegradable polymer scaffolds in vitro显示文摘 | Kerstin S Kristina A Kamal M | | 0，，06： | 1 |
| 10 | Inactivation ofmicroorganisms using pulsed electric fields: The influence of process parameters on escherichia coli, listeria innocua, leuconostoc mesenteroides and saccharomyces cerevisiae 显示文摘 | Martin L | 2001 | Innovative Food Science and Emerging Technologies2001，2，： | 1 |
| 11 | Production of hydrogen by partial oxidation of methanol over Cu/ZnO catalysts prepared by microemulsion technique 显示文摘 | JOHAN A KRISTINA HASELBO A KJELL J B | 2001 | Applied Catalysis2001，211，： | 1 |
| 12 | Pituitary gene expression of somatolactin, prolactin, and growth hormone during Atlantic salmon parrsmolt transformation 显示文摘 | THORLEIFUR A KRISTINA S TATSUYA S | 2003 | Aquaculture2003，222，： | 1 |
| 13 | Toll-like receptor TLR-2 and TLR-4 regulate infammation, gliosis and myelin sparing after spinal cord injury显示文摘 | Kristina A K Wenmin L Serge R | 2007 | J Neurochem2007，102，1： | 1 |
| 14 | Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in viro bioactivity of the Xenoestrogens bisphenol A and Octylphenol显示文摘 | Susan C N Fredrick S Kristina A | 1997 | Environ Health Perspect1997，105，： | 1 |
| 15 | Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and αPo C-Ⅲ genes by activating the nuclear receptor PPAR显示文摘 | Kristina S Jean CF | 1996 | Atherosclerosis1996，124，： | 1 |
| 16 | Inactivation of Escherichia Coli, Listeria Innocua and Saccharomyces Cerevisiae in Relation to Membrane Permeabilization and Subsequent Leakage of Intracellular Compounds due to Pulsed Electric Field Processing显示文摘 | KRISTINA A ULF R ELISABETH B | 2005 | International Journal of Food Microbiology2005，，99： | 1 |
| 17 | Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol显示文摘 | Susan CN Frederick S Kristina A | 1997 | Environ Health Perspect1997，105，： | 1 |
| 18 | Anti-vascular endotheli- algrowth factor for macular oedema secondary to central retinal vein occlusion 显示文摘 | Tasanee B Nanji A A Kristina L | 2014 | Coehrane Database Syst Rev2014，5，5： | 1 |
| 19 | Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis显示文摘 | KRISTINA E BIRGITTA A MARTIN E | 2006 | Arterioscler Thromb Vasc Biol2006，26，4： | 1 |
| 20 | Prevalence of Amblyopia or Strabismus in Asian and Non-Hispanic White Preschool Children:Multi-Ethnic Pediat- ric Eye Disease Study 显示文摘 | Roberta McKean-Cowdin Susan A Cotter Kristina Tarczy-Hor- noch | 2013 | Ophthalmology2013，120，10： | 1 |
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