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| 1 | Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis:Pathogenesis and therapeutic implications显示文摘AIM:To establish the roles of lipopolysaccharide (LPS)/CD14/toll-like receptor 4 (TLR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC).METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups (n=6) for sham operation, treatment with LPS, bowel distension, combined bowel distension and LPS stimulation, and two therapeutic groups. The potential eff icacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ELISA and immunoblotting.RESULTS: Human acute phase NEC tissues displayed significant increases (P<0.05) in levels of TLR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and LPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an LPS-neutralizing peptide.CONCLUSION:LPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking LPS activation and leukocyte infi ltration. | Kwong L Chan Kwong F Wong John M Luk | 2009 | World Journal of Gastroenterology2009，15，38： | 17 |
| 2 | ALD (HfO2)x(Al2O3)(1-x) high-k gate dielectrics for advanced MOS devices application显示文摘 | YU H Y LI M F KWONG | 2004 | Thin Solid Films2004，，9： | 1 |
| 3 | Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease显示文摘 | Sampson U K Dorbala S Limaye A Kwong R Di Carli M F | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 4 | Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam显示文摘 | Geser F Winton M J Kwong LK | 2008 | Acta Neuropathol2008，115，1： | 1 |
| 5 | Recent developments in the biology of fracture repair显示文摘 | Kwong F N Harris M B | 2008 | J Am Acad Orthop Surg2008，16，11： | 1 |
| 6 | Asia-pacific consensus on the management of gastroesophaged reflux disease : update显示文摘 | Kwong M F Nicholas J T Ronnie F | 2008 | J Gastroenterol and Hepatol2008，23，1： | 1 |
| 7 | Influence of citric acid on the hydrolytic reactions of aluminum 显示文摘 | Kwong K F N K Huang P M | 1977 | Soil Science Society of America Journal1977，41，： | 1 |
| 8 | Influence of Citric Acid on the Hydrolytic Reactions of Aluminum显示文摘 | Ng Kee Kwong K F Huang P M | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 9 | Prediction of performance facets using specific personality traits in the Chinese context显示文摘 | Kwong J ~ Cheung F M | 2003 | Journal of Vocational Behavior2003，63，1： | 1 |
| 10 | Observation of four-wave mixing in slow-light silicon phontonic crystal waveguides 显示文摘 | Mcmillan J F Yu M B Kwong D L | 2010 | Opt Express2010，18，15： | 1 |
| 11 | 显示文摘 | LianJ B Ding Z M Kwong F L | 2011 | Cryst Eng Comm2011，13，： | 1 |
| 12 | The role of mitochondria in inherited neurodegenerative diseases 显示文摘 | Kwong J Q Beal M F Manfredi G | 2006 | J Neurochem2006，97，6： | 1 |
| 13 | A dual-metal gate integration process for CMOS with Sub-1-nm EOT HfO2 by using HfN replacement gate显示文摘 | Ren C Yu H Y KangJ F Wang X P Ma H H H Yee-Chia Yeo Daniel Chan S H Li M F Kwong D L | 2004 | IEEE Electron Device Letters2004，25，8： | 1 |
| 14 | Physical and electrical characteristics of HfN gate electrode for advanced MOS devices显示文摘 | Yu H Y Lim H F Chen J H Li M F Zhu Chunxiang Tung C H Du A Y Wang W D Chi D Z Kwong D L | 2003 | IEEE Electron Device Letter2003，24，4： | 1 |
| 15 | A highly efficient chiral-bridged diphosphine ligand modified cationic palladium(Ⅱ)catalyst system for asymmetric alternating copolymerlzation of propene and carbon monoxide显示文摘 | Cni Y M'Wang L L Kwong F Y | 2009 | Synlett2009，，16： | 1 |
| 16 | Analy- sis of a clonal lineage of HIV-1 envelope V2/V3 eonforma- tional epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors 显示文摘 | Bonsignori M Hwang KK Chert X Tsao CY Morris L Gray E Marshall DJ Crump JA Kapiga SH Sam NE Si- nangil F Pancera M Yongping Y Zhang B Zhu J Kwong PD O'Dell S Maseola JR Wu L Nabel GJ Phogat S Seaman MS Whitesides JF Moody MA Kelsoe G Yang X Sodroski J Shaw GM Montefiori DC Kepler TB Tomaras GD Alam SM Liao HX Haynes BF | 2011 | J Virol2011，85，10： | 1 |
| 17 | Transoral robotic surgery in head neck cancer man- agement显示文摘 | KWONG F N PUVANENDRAN M PALERI V | 2015 | B-ENT2015，24，： | 1 |
| 18 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus 显示文摘 | Liao HX Lynch R Zhou T Gao F Alam SM Boyd SD Fire AZ Roskin KM Schramm CA Zhang Z ZhuJ Sha- piro L NISC Comparative Sequencing Program Mullikin JC Gnanakaran S Hraber P Wiehe K Kelsoe G Yang G Xia SM Montefiori DC Parks R Lloyd KE Scearce RM Soderberg KA Cohen M Kamanga G Louder MK Tran LM Chen Y Cai F Chen S Moquin S Du X Joyce MG Srivatsan S Zhang B Zheng A Shaw GM Hahn BH Kepler TB Korber BT Kwong PD Mascola JR Haynes BF | 2013 | Nature2013，496，7446： | 1 |
| 19 | A re- view of landslide problems and mitigation measures in Chongqing and Hong Kong: similarities and d-ifferences显示文摘 | Kwong A K L Wang M Lee C F | 2004 | Engineering Geology2004，76，12： | 1 |
| 20 | Efficient Quantum Key Distribution Scheme and a Proof of Its Unconditional Secu- rity 显示文摘 | Kwong H Chau H F Ardehali M | 2005 | Journal of Cryptology2005，18，： | 1 |
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