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| 1 | Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease显示文摘AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and CD.METHODS: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic biopsies.Microscopic features of ITB and CD were reviewed,and eight pathologic parameters were evaluated.Nine cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,respectively.PCR assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy specimens.RESULTS: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with CD.The sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,respectively.The PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy specimens.Among the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combination of histologic fi ndings and TB-PCR testing led to an increase of diagnostic sensitivity and the increase (from 47.3% to 58.2) was statistically signifi cant with kit (P = 0.000).CONCLUSION: The TB-PCR test combined with histopathologic factors appears to be a helpful technique in formulating the differential diagnosis of ITB and CD in endoscopic biopsy samples. | Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee Young Han Young Chae Chu Kye Sook Kwon Eun Joo Kim | 2010 | World Journal of Gastroenterology2010，16，20： | 20 |
| 2 | 传导性EMI噪声的模态分离与噪声抑制问题探讨显示文摘对传导性电磁干扰 (EMI)噪声的模态分离包括基于硬件器件和基于算法的软分离方法及其优缺点进行了分析和比较 ,同时给出了抑制噪声的功率线滤波器设计方法 ,并讨论了传导性电磁干扰噪声全智能诊断和处理装置 .给出了部分实验结果 ,对其中一些方法作了实验对比 .结果表明 ,基于分相器 /混和器的噪声分离网络具有更好的高频特性 ,且网络插损和噪声模态抑制特性能够满足工程精度要求 ,但网络制造成本较高 . | 赵阳 李世锦 孟照娟 龙云云 沈雪梅 陈昊 See Kye Yak | 2004 | 南京师范大学学报(工程技术版)2004，4，4： | 9 |
| 3 | Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket显示文摘Mechanical lithotripsy(ML) is usually considered as a standard treatment option for large bile duct stones.However,it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the stone.However,there is no established endoscopic extraction method for such giant stone removal.We describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket.A 78-year-old woman had suffered from upper abdominal pain for 20 d.Contrast-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct(CBD).Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large balloon.An attempt to capture the stone using a standard lithotripsy basket failed due to the large stone size.Subsequently,we used a gastric bezoar basket to successfully capturethe stone.The stone was fragmented into small pieces and extracted.The stone was completely removed after two sessions of endoscopic retrograde cholangiopancreatography;each of which took 30 min.No complications occurred during or after the procedure.The patient was fully recovered and discharged on day 11 of hospitalization.ML using a gastric bezoar basket is a safe and effective retrieval method in select cases,and is considered as an alternative nonoperative option for the management of difficult CBD stones. | Hyun Jung Chung Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Byoung Wook Bang Kye Sook Kwon Hyung Kil Kim Yong Woon Shin Young Soo Kim | 2012 | World Journal of Gastroenterology2012，18，25： | 7 |
| 4 | 电机拖动系统中的传导性电磁干扰噪声的测试显示文摘针对电机拖动系统中日益严重的电磁兼容问题,提出了用于传导性电磁干扰噪声诊断的噪声分离网络和噪声智能处理软件平台,并对电机拖动系统中的传导噪声进行特征提取和模态分析,以便为噪声抑制及电磁兼容综合解决方案提供必要信息。此外,对开关磁阻电机构成的风机调速系统进行传导性电磁兼容测试,并对试验数据进行了对比和分析。 | 赵阳 SEE Kye Yak 李世锦 沈雪梅 尹海平 | 2006 | 电机与控制应用2006，33，11： | 7 |
| 5 | An Efficient Noise Source Impedance Estimation Approach Applied in Electromagnetic Compatibility显示文摘 | QIU Xiaohui ZHAO Yang SEE Kye Yak SHEN Xuemei | 2009 | Chinese Journal of Electronics2009，18，4： | 5 |
| 6 | Management of obstructive colon cancer:Current status,obstacles,and future directions显示文摘Approximately 10%–18%of patients with colon cancer present with obstruction at the initial diagnosis.Despite active screening efforts,the incidence of obstructive colon cancer remains stable.Traditionally,emergency surgery has been indicated to treat patients with obstructive colon cancer.However,compared to patients undergoing elective surgery,the morbidity and mortality rates of patients requiring emergency surgery for obstructive colon cancer are high.With the advancement of colonoscopic techniques and equipment,a self-expandable metal stent(SEMS)was introduced to relieve obstructive symptoms,allowing the patient’s general condition to be restored and for them undergo elective surgery.As the use of SEMS placement is growing,controversies about its application in potentially curable diseases have been raised.In this review,the short-and longterm outcomes of different treatment strategies,particularly emergency surgery vs SEMS placement followed by elective surgery in resectable,locally advanced obstructive colon cancer,are described based on the location of the obstructive cancer lesion.Controversies regarding each treatment strategy are discussed.To overcome current obstacles,a potential diagnostic method using circulating tumor DNA and further research directions incorporating neoadjuvant chemotherapy are introduced. | Ri-Na Yoo Hyeon-Min Cho Bong-Hyeon Kye | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 4 |
| 7 | Expression of Ki-67,p53,and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma显示文摘AIM: To examine surgical specimens of pancreas with either chronic pancreatitis or pancreatic cancer in order to study whether ductal hyperplasia and dysplasia in pancreas represent precursor lesions for pancreatic cancer.METHODS: We examined expression of Ki-67, CEA,p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas (n = 11) and chronic pancreatitis (n = 12). Cellular proliferation was assessed by Ki-67proliferation index using the proliferation marker Ki-67.In specimens with pancreas cancer, we divided pancreas epithelium into normal (n=7), ductal hyperplasia (n=3), dysplasia (n=4), and cancerous lesion (n=11) after hematoxylin and eosin staining, Ki-67, and CEA immunohistochemical staining. In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal (n=10), ductal hyperplasia (n=4), or dysplasia (n= 5). p53 and K-ras expression were also studied by immunohistochemical staining.RESULTS: In pancreatic cancer, the Ki-67 index was 3.73±3.58 in normal site, 6.62±4.39 in ductalhyperplasia, 13.47±4.02 in dysplasia and 37.03±10.05in cancer tissue, respectively. Overall, p53 was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 14 (0%), 0 of 7 (0%), 7 of 9 (78%),and 10 of 11 (91%), respectively, and K-ras was positive in 0 of 8 (0%), 1 of 3 (33%), 4 of 6 (67%), 4 of 5 (80%),respectively.CONCLUSION: Our results favorably support the hypothesis that ductal hyperplasia and dysplasia of the pancreas might be precursor lesions for pancreas cancer.Further evaluation of oncogenes by the molecular study is needed. | Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye Sook Kwon Pum-Soo Kim Hyung Gil Kim Yong Woon Shin Young Soo Kim Young Bae Kim | 2005 | World Journal of Gastroenterology2005，11，43： | 4 |
| 8 | 电力电子中的传导性EMI噪声源测量与分析显示文摘对传导性电磁干扰(EMI)噪声源的特性测量与分析作了初步研究,对噪声源产生机理以及噪声源建模方法进行了对比分析,分别讨论了谐振法、插入损耗法和双电流探头法等.此外还采用双电流探头法进行了实际噪声源的内阻抗测定和建模分析,分析结果与采用阻抗仪测得的结果基本吻合.研究为传导性EMI滤波器设计提供了必要条件. | 赵阳 陈昊 尹海平 李世锦 姜宁秋 孙焱 See Kye Yak | 2007 | 南京师范大学学报(工程技术版)2007，7，2： | 3 |
| 9 | Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial显示文摘 | Yi-Long Wu Caicun Zhou Cheng-Ping Hu Jifeng Feng Shun Lu Yunchao Huang Wei Li Mei Hou Jian Hua Shi Kye Young Lee Chong-Rui Xu Dan Massey Miyoung Kim Yang Shi Sarayut L Geater | 2014 | Lancet Oncology2014，，2： | 3 |
| 10 | 传导性电磁兼容关键技术研究显示文摘随着各种电子产品的广泛问世,大量的传导性电磁兼容问题不断出现且尚未得到很好地解决.针对传导电磁兼容中的一些关键技术进行了系统研究,包括通过对传导EMI噪声分离技术对比分析,进行了EMI噪声诊断实验与仿真研究,并提供了噪声抑制与滤波器设计方案;为得到有效的噪声抑制效果,介绍采用双电流探头和希尔伯特变换获取噪声源内阻抗信息;并提出了基于技术与经济一体化的传导电磁兼容决策阐述建模,还给出了EMI噪声抑制及噪声源内阻抗测定的相关实例,以验证方法的有效性. | 赵阳 尹海平 李世锦 姜宁秋 孙焱 See Kye Yak | 2007 | 南京师范大学学报(工程技术版)2007，7，4： | 3 |
| 11 | Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension显示文摘 | Sang-Hyun Ihm Hui-Kyung Jeon Shung Chull Chae Do-Sun Lim Kee-Sik Kim Dong-Ju Choi Jong-Won Ha Dong-Soo Kim Kye Hun Kim Myeong-Chan Cho Sang Hong Baek | 2013 | Chinese Medical Journal2013，，11： | 3 |
| 12 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松弛血管平滑肌以减少微冠状动脉血流阻力。研究尼可地尔的心肌保护作用,IONA研究(尼可地尔对心绞痛的作用)即大规模对稳定型心绞痛进行的研究表明,尼可地尔口服给药能够减少冠心病致死率和非致命型心肌梗塞或胸痛意外住院治疗。目前已经对数个不稳定心绞痛(UAP)或急性心肌梗塞病人进行了尼可地尔心脏保护效应的研究评估,但还没有进行大规模研究。此研究的目的在于通过对经尼可地尔注射并PCI治疗12~48h后的不稳定心绞痛患者的心肌酶进行评估来预期考察尼可地尔的心脏保护作用。 | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬 | 2017 | 首都食品与医药2017，24，18： | 3 |
| 13 | A data-oriented (and beyond) network architecture显示文摘 | Teemu Koponen Mohit Chawla Byung-Gon Chun Andrey Ermolinskiy Kye Hyun Kim Scott Shenker Ion Stoica | 2007 | ACM SIGCOMM Computer Communication Review2007，，4： | 2 |
| 14 | Endoscopic large-balloon sphincteroplasty without preceding sphincterotomy for the removal of large bile duct stones: a preliminary study显示文摘 | Seok Jeong Sung-Ho Ki Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye Sook Kwon Hyung Gil Kim Yong Woon Shin Young Soo Kim | 2009 | Gastrointestinal Endoscopy2009，，5： | 2 |
| 15 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 16 | Synthesis and biological properties of new 1-methylcarbapenms having tetrazolothioether moiety显示文摘 | Kye J S Ki D K | 2000 | Bioorg Med Chem Lett2000，56，36： | 1 |
| 17 | A Single FPGA-Based Portable Ultrasound Imaging System for Point-of-Care Ap-plications 显示文摘 | KIM G D YOON C KYE S B | 2012 | Ultrasonics Ferroelectrics and Frequency Control IEEE Transactions on2012，59，7： | 1 |
| 18 | Theoretical approach for a pressure drop in two-phase partical-laden flows显示文摘 | Kim Seyun Lee Kye Bock Lee Chung Gu | 2007 | Heat and Mass Transfer2007，34，： | 1 |
| 19 | Anti-synchronization of Chaotic Oscillator显示文摘 | Kim C M Rim S Kye W H | 2003 | Phys Lett A2003，320，1： | 1 |
| 20 | Effect of Kp, an antitumor protein-polysaccharide from mycelial culture ofPhellinus linteus on the humoral immune response of tumor-bearing ICR mice to sheep red blood cells显示文摘 | Kyeong -Soo Chung Shin -Sook Kim Hee -Soo Kim Kye -Yang Kim Man -Woo Han Kil -Hyun Kim | 1993 | Archives of Pharmacal Research1993，，4： | 1 |
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