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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Experiments with osteoblasts cultured under varying orientations with respect to the gravity vector显示文摘 | Melissa A. Kacena Paul Todd Louis C. Gerstenfeld William J. Landis | 2002 | Cytotechnology2002，，3： | 1 |
| 3 | The role of megakaryocytes in skeletal homeo- stasis and rheumatoid arthritis 显示文摘 | Kacena MA Horowitz BC | 2006 | Curr Opin Rheumatol2006，18，4： | 1 |
| 4 | The effect of increased peripheral suture purchase on the strength of flexor tendon repairs 显示文摘 | Merrell GA Wolfe SW Kacena WJ | 2003 | J Hand Surg (Am)2003，28，3： | 1 |
| 5 | The clinical and demographic characteristics of nonneurenopathic Gaucher disease in 887 children at diagnosis 显示文摘 | Kaplan P Andersson HC Kacena KA | 2006 | Arch Pediatr Ado- leec Med2006，160，6： | 1 |
| 6 | The clinical and demographic characteristics of nonneuronopathic Gaucher disease in 887 children at di- agnosis显示文摘 | Kaplan P Andersson HC Kacena KA | 2006 | Arch Pediatr Adolese Med2006，160，6： | 1 |
| 7 | Human phenotypes associated with GATA-1 mutations显示文摘 | Ciovacco WA Raskind WH Kacena MA | 2008 | Gene2008，427，12： | 1 |
| 8 | Methods of attenuating pyrotechnic shock显示文摘 | S Barrett W J Kacena | | 0，，01： | 1 |
| 9 | Loss of the transcription factor p45 NF-E2 results in a developmental arrest of megakaryocyte differentiation and the onset of a high bone mass phenotype显示文摘 | Kacena MA Gundberg CM Nelson T | 2005 | Bone2005，36，2： | 1 |
| 10 | A reciprocalregulatory interaction between megakaryocytes, bone cells,and hematopoietic stem cells 显示文摘 | Kacena MA Gundberg CM Horowitz MC | 2006 | Bone2006，39，： | 1 |
| 11 | A reciprocal regulatory interaction between megakaryocytes, bone cells, and hematopoietic stem cells显示文摘 | Kacena MA Gundberg CM Horowitz MC | 2006 | Bone2006，39，5： | 1 |
| 12 | A reciprocalregulatory interaction between megakaryocytes, bone cells,and hematopoietic stem cells 显示文摘 | Kacena MA Gundberg CM Horowitz MC | 2006 | Bone2006，39，： | 1 |
| 13 | The role of megakaryocytes in skeletal homeostasis and rheumatoid arthritis 显示文摘 | KACENA M A HOROWITZ M C | 2006 | Current Pinion in Rheumatology2006，18，4： | 1 |
| 14 | Inflammation and hony changes at the temporomandibular joint显示文摘 | Kacena MA Merrel GA Konda SR | 2001 | Cells Tissues Organs2001，169，3： | 1 |
| 15 | Eight-year clinical outcomes of long-term enzyme replacement therapy for 884 children with Gaucher disease type 1显示文摘 | Andersson H Kaplan P Kacena K Yee J | | 0，，06： | 1 |
| 16 | Experiments with osteoblasts cultured under varying orientations with respect to the gravity vector显示文摘 | Kacena MA Todd P Gerstenfeld LC | 2002 | Cytotechnology2002，39，3： | 1 |
| 17 | The risk of Parkinson's disease in type 1 Gaucher disease显示文摘 | Bultron G Kacena K Pearson D | 2010 | J Inherit Metab Dis2010，33，2： | 1 |
| 18 | Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands 显示文摘 | Xi Y Wilson K Kacena MA | 2001 | Cytokine Growth Factor Rev2001，12，1： | 1 |
| 19 | The effect of increased peripheral suture purchase on the strength of flexor tendon repairs 显示文摘 | Merrell GA Wolfe SW Kacena WJ | 2003 | J Hand Surg Am2003，28，3： | 1 |
| 20 | CD166 and regulation of hematopoiesis显示文摘 | Brahmananda R. Chitteti Monique Bethel Melissa A. Kacena Edward F. Srour | 2013 | Current Opinion in Hematology2013，，4： | 1 |
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