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1010篇 您的检索式：作者名="Pearson D"

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	题名	作者	年代	出处	被引量
1	Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.	Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels	2010	World Journal of Gastroenterology2010，16，6：	11
2	Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘	Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari	2013	Gut2013，，11：	2
3	Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘	Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari	2013	Gut2013，，11：	2
4	Improved tools for biological sequence comparison 显示文摘	PEARSON W R LIPMAN D J	1988	Proc Natl Acad Sci USA1988，85，：	2
5	Comparative in vitro activities of cefotaxime and ceftizoxime (FK749): new cephalosporins with exceptional potency 显示文摘	Greenwood D Pearson N	1980	Antimicrob Agents Chemother1980，17，3：	2
6	Neurohormones from fish tails:the caudal neurosecretory system显示文摘	Pearson D Larson BA	1985	Recent Prog Horm Res1985，41，：	1
7	Effect of culture conditions on growth and sporulation of Bacillus thuringiensis subsp israelensis and development of media for production of the protein Crystal endotoxin显示文摘	PEARSON D WARD O P	1988	Biotechnology Letters1988，10，7：	1
8	cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein,'peritrophin-48',from the larvae of Lucilia cuprina显示文摘	Schorderet S Pearson R D Vuocolo T	1998	Insect Biochemistry and Molecular Biology1998，28，：	1
9	Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients 显示文摘	Lamont J M McManamy C S Pearson A D	2004	Clin Cancer Res2004，10，：	1
10	Critical pathways as a strategy for improving care:Problems and potential显示文摘	Pearson S D Goulart-Fisher D Lee T H	1995	Annals of internal medicine1995，123，12：	1
11	Role of a doxorubi- cin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH 显示文摘	Gutierrez M Chabner BA Pearson D	2000	J CIin Oncol2000，18，21：	1
12	Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘	Smith G A Fitzpatrick L C Pearson W D		0，，：	1
13	Video-rate image correlation processor显示文摘	Pearson J J Hines D C Golosman S		0，，：	1
14	Drip irrigation with waste stabilization pond effluents-solving the problem of emitter fouling显示文摘	Taylor H D Bastos R K X Pearson H W	1995	Water Science and Technology1995，29，4：	1
15	The involvement of cell-to-cell signals in the development of a bacterial biofilm显示文摘	DAVIES D G PARSEK M R PEARSON J P	1998	Science1998，280，5361：	1
16	Transform coding of images using interleaved blocks 显示文摘	Pearson D E Whybray M W	1984	Communications Radar and Signal Processing of IEE Proceedings1984，131，5：	1
17	Potentiation of VSV N J infection in mice by mosquito salive显示文摘	Limesand K H Higgs S Pearson L D	2000	Parascte Immunol2000，22，9：	1
18	Molecular signatures in biopsy specimens of lung cancer显示文摘	Borczuk A C Shah L Pearson G D	2004	Am J Respir Crit Care Med2004，170，2：	1
19	The MUC2 gene product: a human intestinal mucin 显示文摘	Allen A Hutton D A Pearson J R	1998	Int J Biochem Cell Biol1998，30，7：	1
20	Covert visual attention in children with ADHD:Evidence for developmental immaturity?显示文摘	Pearson D Yaffee L Loveland K	1995	Development and Psychopathology1995，7，2：	1

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