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您的检索式：作者名="Kairui Lin"
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| 1 | Novel function of perforin in negatively regulating CD4^+ T cell activation by affecting calcium signaling显示文摘Perforin 是主要从事调停的形成毛孔的蛋白质目标 T 房间死亡并且被细胞毒素的 T 淋巴细胞(CTL ) 和自然漂亮房间采用。然而,它是否也在常规 CD4+ T 房间功能起一个作用,仍然保持不清楚。这里,我们报导那在 perforin 缺乏(PKO ) 老鼠, CD4+ T 房间是响应 T 的 hyperproliferative 房间受体(TCR ) 刺激。hyperproliferation 的这个特征被改进在房间分割并且在 IL-2 分泌物伴随。看起来, perforin 缺乏不在胸腺怒气和淋巴节点影响 T 房间开发。在 vivo, perforin 缺乏导致增加的抗原特定的 T 房间增长和抗体生产。而且, PKO 老鼠更产生试验性的自体免疫的眼色素层炎。探讨分子的机制,我们发现在 TCR 刺激以后,从 PKO 老鼠的 CD4+ T 房间显示增加的细胞内部的钙流动并且随后提高抄写因素 NFAT1 的激活。我们的结果显示 perforin 在由影响 TCR 依赖的 Ca2+ 发信号调整 CD4+ T 房间激活和有免疫力的反应起一个否定作用。 | Enguang Bi Chunjian Huang Yu Hu Xiaodong Wu Weiwen Deng Guomei Lin Zhiduo Liu Lin Tian Shuhui Sun Kairui Mao Jia Zou Yuhan Zheng Bing Sun | 2009 | Cell Research2009，19，7： | 2 |
| 2 | Novel and durable composite phase change thermal energy storage materials with controllable melting temperature显示文摘The development of high temperature phase change materials(PCMs)with great comprehensive performance is significant in the future thermal energy storage system.In this study,novel and durable Al-Si/Al_(2)O_(3)-Al N composite PCMs with controllable melting temperature were successfully synthesized by using pristine Al powder as raw material and tetraethyl orthosilicate as SiO_(2)source.The Al_(2)O_(3)shell and Al-Si alloy were in-situ produced via the substitution reaction between molten Al and SiO_(2).Importantly,the crack caused by the incomplete encapsulation of the Al_(2)O_(3)shell could repair itself by the nitridation reaction of internal molten Al and thereby forming a highly dense Al_(2)O_(3)-Al N composite shell.The produced dense Al_(2)O_(3)-Al N composite shell could significantly improve the thermal cycling stability of composite PCMs,and thus,the thermal storage density decrease of the Al-Si/Al_(2)O_(3)-Al N(59.8 J/g to77.7 J/g)was far less than that of the Al-Si/Al_(2)O_(3)(118.5 J/g)after 3000 thermal cycles.Moreover,the synthesized Al-Si/Al_(2)O_(3)-Al N still exhibited a controllable melting temperature(571.5-637.9℃),relatively high thermal storage density(105.6-150.7 J/g),great dimensional stability and structural stability after3000 thermal cycles.Hence,the synthesized Al-Si/Al_(2)O_(3)-Al N composite PCMs,as promising preferential thermal energy storage materials,can be stably used in the energy utilization efficiency improvement of various systems for more than 6 years. | Haiting Wei Shuiyuan Yang Cuiping Wang Changrui Qiu Kairui Lin Jiajia Han Yong Lu Xingjun Liu | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 3 | Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation显示文摘理解自然变应原导致的气喘的致病是重要的,它能排除人工的助手的干扰并且在疾病提供自然有免疫力的反应的卓见。在现在的学习,我们证明甚至没有明矾的帮助, Trichosanthin (TCS ) 能导致航线发炎。而且, TCS 显得能够代替明矾支持卵特定的航线发炎。TCS 在一个早阶段在腹膜导致了 IL-4-producing 嗜曙红血球的累积, TCS 的辅助功能被 IL-4 的阻塞在这个阶段消除。最后, TCS 从 WT 鼠标,然而并非从 IL-4-deficient 鼠标触发的嗜曙红血球被显示为卵特定的 Th2 回答的正式就职作为助手工作。我们的数据显示 TCS 是不仅变应原,而且一个 Th2 类型助手 modulating 切换对一条 Th2 小径的有免疫力的回答。事件的这链在整洁 TCS 的一个早阶段由嗜曙红血球源于 IL-4 生产。在结论, TCS 可能作为一个 Th2 助手有用,并且天生的有免疫力的房间例如嗜曙红血球,可以是一个好目标学习 Th2 反应的开始。 | Yuan Wang Kairui Mao Shuhui Sun Guomei Lin Xiaodong Wu Gang Yao Bing Sun | 2009 | Cell Research2009，19，8： | 1 |
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