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| 1 | Novel function of perforin in negatively regulating CD4^+ T cell activation by affecting calcium signaling显示文摘Perforin 是主要从事调停的形成毛孔的蛋白质目标 T 房间死亡并且被细胞毒素的 T 淋巴细胞(CTL ) 和自然漂亮房间采用。然而,它是否也在常规 CD4+ T 房间功能起一个作用,仍然保持不清楚。这里,我们报导那在 perforin 缺乏(PKO ) 老鼠, CD4+ T 房间是响应 T 的 hyperproliferative 房间受体(TCR ) 刺激。hyperproliferation 的这个特征被改进在房间分割并且在 IL-2 分泌物伴随。看起来, perforin 缺乏不在胸腺怒气和淋巴节点影响 T 房间开发。在 vivo, perforin 缺乏导致增加的抗原特定的 T 房间增长和抗体生产。而且, PKO 老鼠更产生试验性的自体免疫的眼色素层炎。探讨分子的机制,我们发现在 TCR 刺激以后,从 PKO 老鼠的 CD4+ T 房间显示增加的细胞内部的钙流动并且随后提高抄写因素 NFAT1 的激活。我们的结果显示 perforin 在由影响 TCR 依赖的 Ca2+ 发信号调整 CD4+ T 房间激活和有免疫力的反应起一个否定作用。 | Enguang Bi Chunjian Huang Yu Hu Xiaodong Wu Weiwen Deng Guomei Lin Zhiduo Liu Lin Tian Shuhui Sun Kairui Mao Jia Zou Yuhan Zheng Bing Sun | 2009 | Cell Research2009，19，7： | 2 |
| 2 | Utilization of new soil stabilizer for silt subgrade显示文摘 | Zhu Zhiduo Liu Songyu | 2008 | Engieefing Geology2008，97，： | 1 |
| 3 | Enhanced thermal conductivity of epoxy composites with core-shell SiC@SiO_(2) nanowires显示文摘Electronic packaging materials and thermal interface materials(TIMs)are widely used in thermal management.In this study,the epoxy composites with core-shell structure SiC@SiO_(2) nanowires(SiC@SiO_(2) NWs)as fillers could effectively enhance the thermal conductivity of epoxy composites.The unique structure of fillers results in a high thermal conductivity of epoxy composites,which is attributed to good interfacial compatibility epoxy matrix and bridging connections of SiC@SiO_(2) NWs.From neat epoxy to 2.5 wt%loading of SiC@SiO_(2) NWs,the thermal conductivity is significantly increased from 0.218 to 0.391 W m^(−1) K^(−1),increased by 79.4%.In addition,the composite with 2.5 wt%filler possess lower coefficient of thermal expansion and better thermal stability than that of neat epoxy.All these outstanding properties imply that epoxy/SiC@SiO_(2) NWs composites could be the ideal candidate for TIM. | Dianyu Shen Mengjie Wang Yuming Wu Zhiduo Liu Yong Cao Ting Wang Xinfeng Wu Qingtang Shi Kuan W.A.Chee Wen Dai Hua Bai Dan Dai Jilei Lyu Nan Jiang Cheng-Te Lin Jinhong Yu | 2017 | High Voltage2017，2，3： | 1 |
| 4 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 5 | Influence of Mainstream Turbulence Intensity on Heat Transfer Char- acteristics of a High Pressure Turbine Stage with Inlet Hot Streak 显示文摘 | Wang Zhiduo Liu Zhaofang Feng Zhenping | 2016 | ASME Journal of Turbomachinery2016，138，04： | 1 |
| 6 | A Spiral Graphene Framework Containing Highly Ordered Graphene Microtubes for Polymer Composites with Superior Through-Plane Thermal Conductivity显示文摘As the power density of electronic devices increases,there has been an urgent demand to develop highly conductive polymer composites to address the accompanying thermal management issues.Due to the ultra-high intrinsic thermal conductivity,graphene is considered a very promising filler to improve the thermal conductivity of polymers.However,graphene-based polymer composites prepared by the conventional mixing method generally have limited thermal conductivity,even under high graphene loading,due to the failure to construct efficient heat transfer pathways in the polymer matrix.Here,a spiral graphene framework(SGF)containing continuous and highly ordered graphene microtubes was developed based on a modified CVD method.After embedding into the epoxy(EP)matrix,the graphene microtubes can act as efficient heat pathways,endowing the SGF/EP composites with a high through-plane thermal conductivity of 1.35 W·m^(-1)·K^(-1) at an ultralow graphene loading of 0.86 wt%.This result gives a thermal conductivity enhancement per 1 wt%filler loading of 710%,significantly outperforming various graphene structures as fillers.In addition,we demonstrated the practical application of the SGF/EP composite as a thermal interface material for efficient thermal man-agement of the light-emitting diode(LED). | Jinrui Gong Xue Tan Qilong Yuan Zhiduo Liu Junfeng Ying Le Lv Qingwei Yan Wubo Chu Chen Xue Jinhong Yu Kazuhito Nishimura Nan Jiang Cheng-Te Lin Wen Dai | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 7 | Differential Expression of Neutrophilic Granule Proteins between Th1 and Th2 Cells显示文摘T 助手房间类型 1 ( Th1 )并且( Th2 ) 2 在新奇基因差别在 Th1 和 Th2 房间之间表示了的有免疫力的 regulation.Toidentify 起中央作用,CD4^+ T 房间从 DO11.10 转基因的老鼠被孤立并且在 Th1 或 Th2 conditions.Microarray 下面导致了在 Th1 和 Th2 cells.NGP 之间的 neutrophilic 小粒蛋白质( NGP )的显示出的微分表示首先与相同作为myeloid特定的小粒蛋白质被识别到 cystatin 总科。这里,我们由反向的抄写聚合酶链反应和即时聚合酶链反应分析在 Th2 房间证实了 NGP 的更大的表示。我们也证明 NGP mRNA 的表示在 Th2 下面在 5 d 文化以后有山峰表情 -- 然而并非偏导 Th1 条件。对准备的 NGPwas 的抗体,并且在有 mRNA 分析的结果的音乐会,在蛋白质印迹分析检测的 Th2 房间的 NGP 蛋白质的水平在在 HeLa 房间的 Th1 cells.GFP-NGP 熔化 proteinsoverexpressed 也比那高对细胞质局部性。这些结果建议 NGP 是把 Th2 与 Th 1 房间区分开来的一个新奇标记,也许,新奇 cytokine 由 Th2 房间藏匿。 | De’e XIE~(1,2#) Zhiduo LIU~(1#) Zhenhu LI~1 Yongyong JI~1 Jiwu CHEN~2 and Bing SUN~(1*) ~1Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Shanghai 200031,China ~2School of Life Science,East East China Normal University,Shanghai 200062,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 0 |
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