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2篇 您的检索式：作者名="Kaiwang Shi"

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		题名	作者	年代	出处	被引量
	1	Distinct effect of Chrysanthemum indicum Linné extracts on isoproterenol-inducedgrowth of human hepatocellular carcinoma cells显示文摘	Aihua Yuan Zongfang Li Xinqiu Li Shanyong Yi Shukui Wang Kaiwang Shi Jianmin Bian	2009	Oncology Reports2009，，6：	1
	2	Chrysanthemum indicum linné extracts attenuate the mitogenic effect of epinephrine on human HCC cells显示文摘Objective: To investigate the stimulatory effect of epinephrine(Epi) and the antagonistic effect of Chrysanthemum indicum Linné extracts (CILE) on Epi-induced growth of human hepatocellular carcinoma(HCC) cells. Methods: The stimulatory effect of Epi and inhibitory effect of CILE on the growth of HepG2 and MHCC97H cells were investigated using a proliferation assay in correlation with βadrenergic receptor(β 2-AR) blockade, a MEK1/MEK2 inhibitor, and assessment of MAPK/ERK1/2 intracellular activity. Results: Epi transiently activated MAPK/ERK1/2 in HepG2 and MHCC97H cells, resulting in a burst of growth. The effect of Epi was significantly attenuated by ICI 118551 and U0126. CILE exhibited a dose-dependent attenuation of the stimulatory effect of Epi on the growth of both cell lines and inhibited the Epi-induced activation of MAPK/ERK1/2. Conclusion: Epi, mimicking a mitogen, stimulated the growth of HepG2 and MHCC97H cells, and CILE was effective in attenuating this effect of Epi on tumor cells by inhibiting the β2-AR-mediated activation of MAPK/ERK1/2.	Aihua Yuan Zongfang Li Xinqiu Li Shanyong Yi Shukui Wang Kaiwang Shi Jianmin Bian	2009	Journal of Nanjing Medical University2009，23，4：	0

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