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| 1 | Autoantibodies and hepatitis C virus genotypes in chronic hepatitis C patients in Estonia显示文摘AIM: To determine the prevalence of several autoantibodies in chronic hepatitis C patients, and to find out whether the pattern of autoantibodies was associated with hepatitis C virus (HCV) genotypes.METHODS: Sera from 90 consecutive patients with chronic hepatitis C were investigated on the presence of anti-nuclear (ANA), anti-mitochondrial (AMA), anti-smooth muscle (SMA),anti-liver-kidney microsomal type 1 (LKMA1), anti-parietal cell (PCA), anti-thyroid microsomal (TMA), and anti-reticulin (ARA) autoantibodies. The autoantibodies were identified by indirect immunofluorescence. HCV genotypes were determined by a restriction fragment length polymorphism analysis of the amplified 5' noncoding genome region.RESULTS: Forty-six (51.1%) patients were positive for at least one autoantibody. Various antibodies were presented as follows: ANA in 13 (14.4%) patients, SMA in 39 (43.3%),TMA in 2 (2.2%), and ARA in 1 (1.1%) patients. In 9 cases,sera were positive for two autoantibodies (ANA and SMA).AMA, PCA and LKMA1 were not detected in the observed sera. HCV genotypes were distributed as follows: 1b in 66 (73.3%) patients, 3a in 18 (20.0%), and 2a in 6 (6.7%)patients.CONCLUSION: A high prevalence of ANA and SMA can be found in chronic hepatitis C patients. Autoantibodies are present at low titre (1: 10) in most of the cases. Distribution of the autoantibodies show no differences in the sex groups and between patients infected with different HCV genotypes. | Eva Zusinaite Kaja Metsküla Riina Salupere | 2005 | World Journal of Gastroenterology2005，11，4： | 9 |
| 2 | 造雪机制冰CO2制冷系统的设计与性能分析显示文摘本文在工程方程求解器(EES)中,建立了制冰量分别为50 t/d和100 t/d的片状冰体系(亚临界和跨临界)模型,研究了其在不同环境温度下的热力学性能,并优化了跨临界系统气体冷却器压力和换热器类型。在COMSOL软件中建立了片冰机模型,并进行了设计优化,发现200根管道足以让冰有效冻结。通过改变沸腾温度和冰的厚度,可以提高片状冰机的生产能力。单级亚临界系统在较低的环境温度下表现出较好的性能系数(COP)。当有热水供应或加热需求时,适合采用两级跨临界系统。但两级跨临界系统在制冰时对能量的要求更高,达到33.65(kW·h)/m^3。套管式气体冷却器的应用有利于提高系统的总COP和热回收效率。 | Trygve M.EIKEVIK Ignat TOLSTOREBROV Kaja Wright BERGWITZ-LARSEN Jon-Brede DIESETH | 2020 | 制冷技术2020，40，2： | 4 |
| 3 | The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells显示文摘与正规象 ubiquitin 一样蛋白质不同, Hub1 不形成共有原子价与底层结合,但是 proteinsnon-covalently 绑。在 Saccharomyces cerevisiae, Hub1 与 spliceosomes 联系并且调停,没有影响通常拼接的 pre-mRNA SRC1 的其他的拼接。人的 Hub1 高度类似于它的酵母相当或相同的事物,而是它的细胞的 functionremains 大部分未经勘探。这里,我们证明人的 Hub1 作为在酵母绑在 spliceosomal 蛋白质 Snu66;然而, unlikeits S。cerevisiae 相当或相同的事物,人的 Hub1 为生存能力是必要的。在 Hub1 导致的人的 vivo 弄空延长了各种各样的细胞的缺点,包括拼接的点缀畸形,部分原子 retentionof mRNAs,有丝分裂的大祸,并且因而由 apoptosis 的房间死亡。然而, Hub1 弄空的早后果仅仅是严重 splicingdefects 为特定拼接地点导致 exon 跳过和 intron 保留。因此,象 ubiquitin 一样 proteinHub1 不是为拼接,而是其他的拼接的 spliceosome performanceand facilitator 的一个调节的人通常需要的一个正规 spliceosomal 因素。 | Tim Ammon Shravan Kumar Mishra Kaja Kowalska Grzegorz M. Popowicz Tad A. Holak Stefan Jentsch | 2014 | Journal of Molecular Cell Biology2014，8，4： | 2 |
| 4 | Intracellular mechanisms ofN-acyletha nolamine-mediated neuroprotection in a rat model ofstroke显示文摘 | Garg P Duncan RS Kaja S | 2010 | Neuroscience2010，166，1： | 1 |
| 5 | Toxicity of nanoparticles of ZnO, CuO and TiO 2 to yeast Saccharomyces cerevisiae显示文摘 | Kaja Kasemets Angela Ivask Henri-Charles Dubourguier Anne Kahru | 2009 | Toxicology in Vitro2009，，6： | 1 |
| 6 | Alterations of riparian ecosystem is caused by river regulation 显示文摘 | Nilsson C B Kajas | 2000 | Bioscienee2000，50，9： | 1 |
| 7 | Collaborative Policymaking-local sustainable projects 显示文摘 | Jon Vernon Stephen Essex David Pinder Kaja Curry | 2005 | Annals of Tourism Research2005，32，2： | 1 |
| 8 | Leptin during and after preeclamptic or normal pregnancy: its relation to serum insulin and insulin sensitivity显示文摘 | Laivuori H Kaja R Koistinen H | 2000 | Metabolism2000，49，： | 1 |
| 9 | Comparison of knowledge, attitudes and behaviour regarding smoking among Estonian and Finnish physicians显示文摘 | Kersti P?rna Kaja Rahu No?l C. Barengo Mati Rahu Patrick H. Sandstr?m Vesa J. Jormanainen Markku T. Myllykangas | 2005 | Sozial - und Pr?ventivmedizin SPM2005，，6： | 1 |
| 10 | Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections显示文摘 | Kaja S Yang SH Wei J | 2003 | Invest Ophthalmol Vis Sci2003，44，7： | 1 |
| 11 | Effect of cadmium on the monolayer maintenance of vascular endothelial cells in culture显示文摘 | Mishima A Koyanagi E | 1992 | Toxicology1992，71，： | 1 |
| 12 | Quality im- provement in the Estonian health system-assessment of progress us- ing an intenmtional tool显示文摘 | KAJA Polluste JARNO Habicht RUTtt Kalda | 2006 | International Journal for Quality in Health Care2006，18，6： | 1 |
| 13 | Tests of Financial Intermediation and Banking Reform in China显示文摘 | Park Albert & Kaja Sehert | 2001 | Journal of Comparative Economics2001，29，4： | 1 |
| 14 | Monitoring of warmed-over flavour in pork using the electronic nose – correlation to sensory attributes and secondary lipid oxidation products显示文摘 | Kaja Tikk John-Erik Haugen Henrik J. Andersen Margit D. Aaslyng | 2008 | Meat Science2008，，4： | 1 |
| 15 | Leptin during and after preeclamptie or mormal pregnancy:its relation to serum insulin and insulin sensitivity 显示文摘 | Laivuofi H Kaja R Koistinen H | 2000 | Metabolism2000，49，： | 1 |
| 16 | Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-L/Homer Ie immunoreactive synaptic connections显示文摘 | Kaja S Yang SH Wei J | 2003 | Invest Ophthalmol Vis Sci2003，44，： | 1 |
| 17 | Changes in the Daphnia magna midgut upon ingestion of copper oxide nanoparticles:A transmission electron microscopy study显示文摘 | Margit H Anne K Kaja K | 2011 | Water Research2011，45，1： | 1 |
| 18 | Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast saccharomyces cerevisiae显示文摘 | Kaja K Angela I Henri-Charles D | 2009 | Toxicology in Vitro2009，23，11： | 1 |
| 19 | Effect of pH on the microstructure of nickel electrodeposits : A TEM study 显示文摘 | Kaja S Pickering H W Bider W R | 1988 | Plat Surf Finish1988，75，1： | 1 |
| 20 | Genetic models of migraine显示文摘 | van de Ven RC Kaja S Plomp JJ | 2007 | Arch Neurol2007，64，5： | 1 |
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