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| 1 | Selective embolization for bleeding visceral artery pseudoaneurysms in patients with pancreatitis显示文摘BACKGROUND:Pancreatitis is associated with arterial complications in 4%-10%of patients,with untreated mortality approaching 90%.Timely intervention at a specialist center can reduce the mortality to 15%.We present a single institution experience of selective embolization as first line management of bleeding pseudoaneurysms in pancreatitis. METHODS:Sixteen patients with pancreatitis and visceral artery pseudoaneurysms were identified from searches of the records of interventional angiography from January 2000 to June 2007.True visceral artery aneurysms and pseudoaneurysms arising as a result of post-operative pancreatic or biliary leak were excluded from the study. RESULTS:In 50%of the patients,bleeding complicated the initial presentation of pancreatitis.Alcohol was the offending agent in 10 patients,gallstones in 3,trauma,drug-induced and idiopathic pancreatitis in one each.All 16 patients had a contrast CT scan and 15 underwent coeliac axis angiography. The pseudoaneurysms ranging from 0.9 to 9.0 cm affected the splenic artery in 7 patients:hepatic in 3,gastroduodenal and right gastric in 2 each,and left gastric and pancreatico-duodenal in 1 each.One patient developed spontaneous thrombosis of the pseudoaneurysm.Fourteen patients had effective coil embolization of the pseudoaneurysm.One patient needed surgical exclusion of the pseudoaneurysm following difficulty in accessing the coeliac axis radiologically.There were no episodes of re-bleeding and no in-hospital mortality. CONCLUSIONS:Pseudoaneurysms are unrelated to the severity of pancreatitis and major hemorrhage can occur irrespective of their size.Co-existent portal hypertension and sepsis increase the risk of surgery.Angiography and selective coil embolization is a safe and effective way to arrest the hemorrhage. | Harsheet Sethi Praveen Peddu Andreas Prachalias Pauline Kane John Karani Mohamed Rela Nigel Heaton | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 12 |
| 2 | Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma显示文摘Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. | Ruchi Sharma Abid Suddle Alberto Quaglia Praveen Peddu John Karani Thomas Satyadas | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 7 |
| 3 | Lasiopodomys fuscus as an important intermediate host for Echinococcus multilocularis:isolation and phylogenetic identification of the parasite显示文摘Background:Echinococcus multilocularis causes alveolar echinococcosis(AE)and is widely prevalent in Qinghai Province,China,where a number of different species have been identified as hosts.However,limited information is available on the Qinghai vole(Lasiopodomys fuscus),which is hyper endemic to Qinghai Province and may represent a potential intermediate host of E.multilocularis.Thus,L.fuscus could contribute to the endemicity of AE in the area.Methods:Fifty Qinghai voles were captured from Jigzhi County in Qinghai Province for the clinical identification of E.multilocularis infection via anatomical examination.Hydatid fluid was collected from vesicles of the livers in suspected voles and subjected to a microscopic examination and PCR assay based on the barcoding gene of cox 1.PCR-amplified segments were sequenced for a phylogenetic analysis.E.multilocularis-infected Qinghai voles were morphologically identified and subjected to a phylogenetic analysis to confirm their identities.Results:Seventeen of the 50 Qinghai voles had E.multilocularis-infection-like vesicles in their livers.Eleven out of the 17 Qinghai voles presented E.multilocularis infection,which was detected by PCR and sequencing.The phylogenetic analysis showed that all 11 positive samples belonged to the E.multilocularis Asian genotype.A morphological identification and phylogenetic analysis of the E.multilocularis-infected Qinghai voles confirmed that all captured animals were L.fuscus.Conclusions:L.fuscus can be infected with E.multilocularis and plays a potential role in the life cycle and epidemiology of E.multilocularis in the Qinghai-Tibetan Plateau of China. | Qi-Gang Cai Xiu-Min Han Yong-Hai Yang Xue-Yong Zhang Li-Qing Ma Panagiotis Karanis Yong-Hao Hu | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 4 | Liver resection for the treatment of a congenital intrahepatic portosystemic venous shunt显示文摘Intrahepatic portosystemic shunts(IPSS) are rare congenital anomalies arising from disordered portal vein embryogenesis.It has been described in both children and adults and may be asymptomatic or be associated with a variety of neurophysiological and pulmonary complications.When recognized,early intervention to occlude the shunt will reverse the associated complications.Literature review reports of surgical and radiological occlusion of the shunt,but due to its rarity,a standard therapeutic protocol has not been established.A case of a 38-year-old woman with abdominal pain and low grade encephalopathy,diagnosed with an IPSS and treated by right hepatectomy was reported. | michail papamichail amir ali alberto quaglia john karani nigel heaton | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 2 |
| 5 | Evaluation of three flocculation methods for the purification of Cryptosporidium parvumoocysts from water samples显示文摘 | Karanis P Kimura A | 2002 | Lett Appl Microbiol2002，34，6： | 1 |
| 6 | Chronic Mesenteric Venous Thrombosis: Evaluation and Determinants of Survival During Long-Term Follow-up显示文摘 | David W. Orr Phillip M. Harrison John Devlin John B. Karani Pauline A. Kane Nigel D. Heaton John G. O’Grady Michael A. Heneghan | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 7 | Evaluation of loop-mediated isothermal amplification for detection of Toroplasma gondii in water samples and comparative findings by polymerase chain reaction and immunofluorescence test (IFT)显示文摘 | Sotiriadou I Karanis P | 2008 | Diagnostic Microbiology and Infectious Disease2008，62，4： | 1 |
| 8 | Cryopreservation of protozoan para- sites 显示文摘 | Miyake Y Karanis P Uga S | 2004 | Cryobiology2004，48，1： | 1 |
| 9 | Stenoses of vascular anas tomoses after hepatic transplantation: treatment with balloon angioplasty显示文摘 | Raby N Karani J Thomas S | 1991 | Am J Roentgenol1991，157，： | 1 |
| 10 | Evaluation of loop-mediated isother- mal amplification for detection of Toxoplasma gondii in water samples and comparative findings by pulymerase chain reac-tion and immunofluorescence test(lFT)显示文摘 | Sotiriadou I Karanis P | 2008 | Diagn Microbiol In- fect Dis2008，62，4： | 1 |
| 11 | Waterborne transmission of pro- tozoan parasites:Review of worldwide outbreaks-An up- date 2004--2010显示文摘 | BALDURSSON S KARANIS P | 2011 | WaterRes2011，45，20： | 1 |
| 12 | Distribution of Salmonella pathogenicity island (SPI)-8 and SPI-10 among different serotypes of Salmonella 显示文摘 | Saroj SD Shashidhar R Karani M Bandekar JR | 2008 | J Med Microbiol2008，57，4： | 1 |
| 13 | Development and preliminary evaluation of a loop-mediated isothermal amplification procedure for sensitive detection of cryptosporidium oocysts in fecal and water samples 显示文摘 | Karanis P Thekisoe O Kiouptsi K | 2007 | Appl Environ Microbiol2007，73，17： | 1 |
| 14 | Waterborne transmission of protozoan parasites : a review of world - wide outbreaks and lessons learnt显示文摘 | Karanis P Kourenti C Smith H | 2007 | Wat Health2007，5，： | 1 |
| 15 | Genetic polymorphism in Cryptosporidium species:an update显示文摘 | Plutzer J Karanis P | 2009 | Vet Parasitol2009，165，34： | 1 |
| 16 | Increasing dehydration of human cleavage stage embryos prior to slow cooling significantly increases cryosurvival 显示文摘 | Edgar DH Karani J Gook DA | 2009 | Reprod Biomed Online2009，19，4： | 1 |
| 17 | Autoimmune hepatitis sclersing cholangitis overlap syndrome in childhood:a 16-year prospective study显示文摘 | GREGORIO G V PORTMANN B KARANI J | 2001 | Hepatology2001，33，： | 1 |
| 18 | Evaluation of loop-mediated isothermal amplification for detection of Toxoplasrna gondii in water samples and comparative findings by polymerase chain reaction and immnnofluorescence test (IFT) 显示文摘 | Sotiriadou I Karanis P | 2008 | Diagn Microbiol Infect Dis2008，62，4： | 1 |
| 19 | Cerebral manifestations inliver disease and transplantation显示文摘 | Dineen RA Sibtain N Karani JB | 2008 | Clinical Radiology2008，63，5： | 1 |
| 20 | The use of percutaneous transluminal angioplasty in hepatic artery stenosis after transplantation显示文摘 | Mondragon RS Karani JB Heaton ND | 1994 | Transplantation1994，57，2： | 1 |
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