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| 1 | Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma显示文摘Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. | Ruchi Sharma Abid Suddle Alberto Quaglia Praveen Peddu John Karani Thomas Satyadas | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 7 |
| 2 | 坏死性筋膜炎1例显示文摘报告1例具有典型症状的坏死性筋膜炎。患者女,70岁。皮损位于左臀部和左大腿,为显著性红斑、硬结、片状坏死,皮损有恶臭,组织中有产气现象,自觉疼痛剧烈。经组织病理检查确诊为坏死性筋膜炎。对患者施行清创术和对症支持治疗,包括消炎、镇痛和补液,获得令人满意的疗效。 | Virendra N Sehgal Naresh Sehgal Ruchi Sehgal Sujay Khandpur Sonal Sharma | 2005 | 临床皮肤科杂志2005，34，2： | 2 |
| 3 | Phaseolin: A 47.5kDa protein of red kidney bean ( Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction显示文摘 | Sandeep Kumar Alok Kumar Verma Akanksha Sharma Ruchi Roy Dinesh Kumar Giridhar BH Anurag Tripathi Bhushan P. Chaudhari Mukul Das S.K. Jain Premendra D. Dwivedi | 2014 | International Immunopharmacology2014，，1： | 1 |
| 4 | Association studies of catechol- O -methyltransferase ( COMT ) gene with schizophrenia and response to antipsychotic treatment显示文摘 | Meenal Gupta Pallav Bhatnagar Sandeep Grover Harpreet Kaur Ruchi Baghel Yasha Bhasin Chitra Chauhan Binuja Verma Vallikiran Manduva Odity Mukherjee Meera Purushottam Abhay Sharma Sanjeev Jain Samir K Brahmachari Ritushree Kukreti | 2009 | Pharmacogenomics2009，，3： | 1 |
| 5 | Portable comprehensive two-dimensional microgas chromatography using an integrated flowrestricted pneumatic modulator显示文摘Two-dimensional(2D)gas chromatography(GC)provides enhanced vapor separation capabilities in contrast to conventional one-dimensional GC and is useful for the analysis of highly complex chemical samples.We developed a microfabricated flow-restricted pneumatic modulator(FRPM)for portable comprehensive 2D micro-GC(μGC),which enables rapid ^(2)D injection and separation without compromising the ^(1)D separation speed and eluent peak profiles.^(2)D injection characteristics such as injection peak width and peak height were fully characterized by using flow-through micro-photoionization detectors(μPIDs)at the FRPM inlet and outlet.A ^(2)D injection peak width of~25 ms could be achieved with a ^(2)D/^(1)D flow rate ratio over 10.The FRPM was further integrated with a 0.5-m long ^(2)D μcolumn on the same chip,and its performance was characterized.Finally,we developed an automated portable comprehensive 2D μGC consisting of a 10m OV-11D μcolumn,an integrated FRPM with a built-in 0.5m polyethylene glycol ^(2)D μcolumn,and two μPIDs.Rapid separation of 40 volatile organic compounds in~5 min was demonstrated.A hybrid 2D contour plot was constructed by using both ^(1)D and ^(2)D chromatograms obtained with the two μPIDs at the end of the ^(1)D and ^(2)D μcolumns,which was enabled by the presence of the flow resistor in the FRPM. | Xiaheng Huang Maxwell Wei-hao Li Wenzhe Zang Xiaolu Huang Anjali Devi Sivakumar Ruchi Sharma Xudong Fan | 2022 | Microsystems & Nanoengineering2022，8，6： | 0 |
| 6 | Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India显示文摘Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir(J&K).The understanding of genetics in Esophageal cancer development is poor in the state.Genome wide association studies(GWAS)has proved to be unsurpassed tool in identification of new loci associated with different cancers.GWAS in Chinese population has identified SNP rs2294693 present in UNC5CL(UNC-5 Family C-Terminal like)to be associated with non-cardia gastric cancer.We performed a case control association study and genotyped the SNP rs2294693 using Taqman allele discrimination assay in 566 individuals(166 esophageal cancer patients and 400 controls)belonging to the J&K population.A statistically significant protective association with allelic odds ratio of 0.73(0.56–0.94 at 95%CI)and p value=0.016 was observed.This is the first study in relation to esophageal cancer in the Jammu and Kashmir population,so far it has been studied in association with gastric carcinoma in the Chinese population only.The results indicate that the polymorphism rs2294693 is associated with esophageal cancer susceptibility and the mutant(T)allele might be a protective factor for esophageal cancer among Jammu and Kashmir population.Further the functional characterization of the variation is also warranted. | RUCHI SHAH SONALI VERMA AMRITA BHAT GH RASOOL BHAT VARUN SHARMA INDU SHARMA HEMENDER SINGH SANDEEP KAUL EKTA RAI SWARKAR SHARMA | 2021 | BIOCELL2021，45，3： | 0 |
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