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| 1 | Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L.stem bark in Swiss albino mice显示文摘Objective:To evaluate the antitumor activity of Manilkara zapota(M.zapota) L.stem bark against Ehrlich ascites carcinoma(EAC) in Swiss albino mice.Methods:The in vivo antitumour activity of the ethyl acetate extract of stem bark of M.zapota L.(EASM) was evaluated at 50,100 and 200 mg/kg bw against EAC using mean survival time.After administration of the extract of M.zapota,viable EAC cell count and body weight in the EAC tumour hosts were observed.The animal was also observed for improvement in the haematological parameters(e.g.,heamoglobin content,red and white blood cells count and differential cell count) after EASM treatment. Results:Intraperitoneal administration of EASM reduced viable EAC cells,increased the survival lime,and restored altered haematological parameters.Significant efficacy was observed for EASM at 100 mg/kg dose(P<0.05).Conclusions:It can be concluded that the elhyl acetate extract of stem bark of M.zapota L.possesses significant antitumour activity. | M Abu Osman M Mamunur Rasbid M Abdul Aziz M Rowshahul Habib M Rezaul karim | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 5 |
| 2 | Vitamin D deficiency in pregnant women and their newborns as seen at a tertiary-care center in Karachi,Paki- stan显示文摘 | Karim SA Nusrat U Aziz S | 2011 | Int J Gynaecol Obstet2011，112，1： | 1 |
| 3 | Use of Optical Biosensor Technology to Study Immunological Cross-Reactivity between Different Sulfonamide Drugs显示文摘 | Ateeq Ahmad Anand Ramakrishnan McLean Matthew A Li Dongbei Rock Marie T Karim Aziz and Breau Alan P | 2002 | Analytical Biochemistry2002，，： | 1 |
| 4 | International noninterventional study of acarbose treatment in patients with type 2 diabetes mellitus显示文摘 | Chunlin Li Yi-Jen Hung Karim Qamruddin Mohamed Fahmy Abdel Aziz Herbert Stein Birgit Schmidt | 2011 | Diabetes Research and Clinical Practice2011，，1： | 1 |
| 5 | Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects显示文摘 | Ronald Christopher Paul Covington Michael Davenport Penny Fleck Qais A. Mekki Elisabeth R. Wann Aziz Karim | 2008 | Clinical Therapeutics2008，，3： | 1 |
| 6 | Flame development characteristics at variable swirl level inductions in a stratified CNG direct injection combustion engine显示文摘 | Yohannes T. Anbese A. Rashid A. Aziz Zainal Ambri B. A. Karim | 2009 | Journal of Energy and Power Engineering2009，2，12： | 0 |
| 7 | National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma显示文摘A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the experts.The Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this meeting.This effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these patients.This coordinated effort can minimise delays and give patients a chance for curative treatment and effective palliation.The diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance cholangiopancreato-graphy.Brush cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for diagnosis.However,histopathologic confirmation is not always required before resection.Endoscopic ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for staging.The only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette classification.Selected patients with unresectable hCCA can be considered for liver transplantation.Adjuvant chemotherapy should be offered to patients with a high risk of recurrence.The use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary discussions.Patients with acute cholangitis can be drained with endoscopic or percutaneous biliary drainage.Palliative chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA. | Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed | 2024 | World Journal of Gastroenterology2024，30，9： | 0 |
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