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| 1 | Effects of a 24-week course of interferon-αtherapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma显示文摘AIM:To assess whether a 24-wk course of interferon (IFN)could prevent hepatocellular carcinoma(HCC) recurrence and worsening of liver function in patients with hepatitis C virus(HCV)-infected patients after receiving curative treatment for primary HCC. METHODS:Outcomes in 42 patients with HCV infection treated with IFN-α,after curative treatment for primary HCC(IFN group),were compared with 42 matched curatively treated historical controls not given IFN(non- IFN group). RESULTS:Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%,44%,61%,and 67% vs 4.8%,53%,81%,and 87% at 1,3,5,and 7 years,P=0.153,respectively), IFN group showed a lower rate than the non-IFN group for second recurrence(0%,10.4%,28%,and 35% vs 0%,30%,59%,and 66% at 1,3,5 and 7 years, P=0.022,respectively).Among the IFN group,patients with sustained virologic response(SVR)were less likely to have a second HCC recurrence than IFN patients without an SVR,or non-IFN patients.Multivariate analysis identified the lack of SVR as the only independent risk factor for a second recurrence,while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION:Most intrahepatic recurrences of HCV- related HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival. | Soo Cheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 2 | Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma显示文摘AIM: To assess the efficacy of low-dose intermittent interferon (IFN) therapy in patients with hepatitis C virus (HCV)-related compensated cirrhosis who had received curative treatment for primary hepatocellular carcinoma (HCC). METHODS: We performed a prospective case controlled study. Sixteen patients received 3 MIU of natural IFN- alpha intramuscularly 3 times weekly for at least 48 wk (IFN group). They were compared with 16 matched historical controls (non-IFN group). RESULTS: The cumulative rate of first recurrence of HCC was not significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 68.6% vs 80% at 1- and 3-year, P = 0.157, respectively). The cumulative rate of second recurrence was not also significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 35.9% vs 67% at 1- and 3-year, P = 0.056, respectively). Although the difference in the Child-Pugh classification score between the groups at initial treatment of HCC was not signifi cant, the score was signifi cantly worse at the time of data analysis in the non-IFN group than IFN group (7.19 ± 1.42 vs 5.81 ± 0.75, P = 0.0008). The cumulative rate of deviation from objects of any treatment for recurrentHCC was also higher in the non-IFN group than IFN group (6.7% and 27% vs 0 and 0% at 1- and 3-year, P = 0.048, respectively). CONCLUSION: Low-dose intermittent IFN-alpha therapy for patients with HCV-related compensated cirrhosis after curative HCC treatment was effective by making patients tolerant to medical or surgical treatment for recurrent HCC in the later period of observation. | Soocheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，39： | 2 |
| 3 | Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis显示文摘 | Yoshio Katamura Hiroshi Aikata Shintaro Takaki Takahiro Azakami Tomokazu Kawaoka Koji Waki Akira Hiramatsu Yoshiiku Kawakami Shoichi Takahashi Masahiro Kenjo Naoyuki Toyota Katsuhide Ito Kazuaki Chayama | 2009 | Journal of Gastroenterology2009，，5： | 2 |
| 4 | Hypersensitivity Reactions to Transcatheter Chemoembolization with Cisplatin and Lipiodol Suspension for Unresectable Hepatocellular Carcinoma显示文摘 | Tomokazu Kawaoka Hiroshi Aikata Yoshio Katamura Shintaro Takaki Koji Waki Akira Hiramatsu Shoichi Takahashi Masashi Hieda Hideaki Kakizawa Kazuaki Chayama | 2010 | Journal of Vascular and Interventional Radiology2010，，8： | 1 |
| 5 | Zoledronic acid delays disease progression of bone metastases from hepatocellular carcinoma显示文摘 | Katamura Y Aikata H Hashimoto Y | | 0，，10： | 1 |
| 6 | Xan- thogranulomatous pyelonephritis: clinical experience of 8 cases 显示文摘 | Nishimura M Arai E Katamura E | 1988 | Hinyokika Kiyo1988，34，7： | 1 |
| 7 | Effect of a Magnetic Field on the Formation of CaCO3 Particles显示文摘 | Higashitani K Kage A Katamura S | 1993 | J Coll Int Sci1993，156，6： | 1 |
| 8 | Distribution and characterization of immunoreactive adrenomedullin in porcine tissue ,and isolation of adrenomedulinand adrenomedullin from porcine duodenum显示文摘 | Ichiki Y Katamura K Kangawa K | 1995 | J Biothem1995，118，4： | 1 |
| 9 | Prostaglandin E2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production显示文摘 | Abe N Katamura K Shintaku N et aI | 1997 | Cell Immunol1997，181，1： | 1 |
| 10 | Catalysis by Hetempoly Compounds Ⅲ,the Structure and Properties of 12-Heteropolyacids of Molybdenum and Tungsten(H3PMo12-x Wx O4o) and Their Salts Pertient to Heterogeneous Catalysis显示文摘 | Misono M Mizuno N Katamura K | | 0，，： | 1 |
| 11 | lntra-arteria 5-fluorouracil/interferon combination therapy fo hepatocellular carcinoma with portal vein tumor thrombosi and extrahepatic metastases显示文摘 | Katamura Y Aikata H Kimura Y | | J Gastroen Hepatol0，，： | 1 |
| 12 | Effects of a magnetic field on the formation of CaCO3 particles 显示文摘 | Higashitani K Kage A Katamura S | 1993 | J Coil Int Sci1993，156，1： | 1 |
| 13 | Immunoreactive adrenomedullin in human plasma 显示文摘 | Katamura K Ichiki Y Tanaka M | 1994 | FEBS Lett1994，341，： | 1 |
| 14 | Zoledronic acid delays disease progression of bone metastases from hepatocellular carcinoma显示文摘 | Katamura Y Aikata H Hashimoto Y | 2010 | Hepatol Res2010，7，10： | 1 |
| 15 | Pilot study of systemic combination therapy with S - 1, an oral fluoropyrimidine, and cispl- atin for hepatocellular carcinoma with extrahepatic metastases 显示文摘 | Katamura Y Aikata H Hashimoto Y | 2010 | Hepatogastroenterology2010，57，102103： | 1 |
| 16 | Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs显示文摘 | Henderson NC Arnold TD Katamura Y | 2013 | N at Med2013，19，： | 1 |
| 17 | Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response显示文摘 | Kazuichi Okazaki * Kazushige Uchida * Masaya Ohana * Hiroshi Nakase * Suguru Uose * Maki Inai * Yumi Matsushima * Kenji Katamura ? Katsuyuki Ohmori § Tsutomu Chiba * | 2000 | Gastroenterology2000，，3： | 1 |
| 18 | Influence of interaction between neighboring oxygen ions on phase stability in cubic zirconia 显示文摘 | KATAMURA J IKUHARA Y | 2002 | J Am Ceram Soc2002，85，10： | 1 |
| 19 | Increased plasma adrenomedullin in acute myocardial infarction 显示文摘 | Katamura K Kobayashi K Hirayama N | 1996 | Am Heart J1996，131，： | 1 |
| 20 | Prostaglandin E2 and IL-4 provide nave CD4+T cells with distinct inhibitory signals for of IFN-r production显示文摘 | Abe N Katamura K Shintaku N | 1997 | Cell Immunology1997，181，： | 1 |
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