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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Novel α- and -amino acid inhibitors of influenza virus neuraminidase 显示文摘 | Kati W M Montgomery D Maring C | 2001 | Antimicrob Agents Chemother2001，45，9： | 3 |
| 3 | Evolutionary relationships of virus species belonging to a distinct lineage within the Ampelovirus genus 显示文摘 | Maliogka V I Dovas C I Katis N I | 2008 | Virus Reseach2008，135，： | 1 |
| 4 | Generic and species- specific detection of viruses belonging to an evolutionary distinct lin- eage within the Ampelovirus genus 显示文摘 | MALIOGKA V I DOVAS C I KATIS N I | 2008 | Journal of Virological Meth- ods2008，154，： | 1 |
| 5 | Visualizing knowledge domains 显示文摘 | Katy B Chaomei C Kevin W B | 2003 | Annual Review of Information Science & Technology2003，37，1： | 1 |
| 6 | A spot nested RT-PCR method for the simultaneouss detection of members of the Vitivirus and Foveavirus genera in grape-vine显示文摘 | Ovas C I Katis N I | 2003 | J Virol Methods2003，107，： | 1 |
| 7 | Front-line paclitaxel and topotecan chemotherapy in advanced or metastatic non-small-cell lung cancer: a phase Ⅱ trial 显示文摘 | Stathopoulos GP Katis C Tsavdaridis D | 2006 | Cancer Chemother Pharmacol2006，58，4： | 1 |
| 8 | Multiplex detection of crinivir- uses associated with epidemics of a yellowing disease of tomato in Greece 显示文摘 | Dovas C I Katis N I Avgelis A D | 2002 | Plant Disease2002，86，12： | 1 |
| 9 | Visualizing Knowledge Do- mains显示文摘 | Katy B Chaomei C Kevin W B | 2003 | Annual Review of Information Science Technolo- gy2003，37，1： | 1 |
| 10 | The role of S100B protein, neuron-specific enolase,and glial fibrillary acidic protein in the e- valuation of hypoxic brain injury in acute carbon monoxide poi- soning显示文摘 | Akdemir H Yardan T Kati C | 2014 | Hum Exp Toxicol2014，33，11： | 1 |
| 11 | Simultaneous Nitrification and Denitrification Using Stored Substrate (PHB) as the Electron Donor in an SBR显示文摘 | KATIE A T NATALIE B RALF C R | 2003 | Biotechnol Bioeng2003，83，： | 1 |
| 12 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 13 | The Effect of Dissolved Oxygen on PHB Accumulation in Activated Sludge Cultures显示文摘 | Katie A T Mark N Ralf C | 2003 | Biotechnology and Bioengineering2003，82，： | 1 |
| 14 | Characterization of crystalline cellulose in biomass: basic principles, applications, and limitations of XRD, NMR, IR, Raman, and SFG显示文摘 | Kim S H Lee C M Katie K | 2013 | Korean Journal Chemistry Engineering2013，30，12： | 1 |
| 15 | Multiplex detection of criniviruses associated with epidemics of a yellowing dis- ease of tomato in Greece 显示文摘 | Dovas C I Katis N I Avgelis A D | 2002 | Plant Disease2002，86，： | 1 |
| 16 | Comparison of propofol and sevoflurane for laryngeal mask airway insertion 显示文摘 | Kati I Demirel C B Huseyinogly U A | 2003 | Tohoku J Exp Med2003，，200： | 1 |
| 17 | Immediate and postoperative complications of transurethral prostatectomy in 1990s显示文摘 | Borborglu P G Katie C J Ward J F | 1999 | J Urol1999，162，： | 1 |
| 18 | The effect of EDTA and citric acid on phytoremediation of Cd,Cr,and Ni from soil using Helianthus annuus显示文摘 | TURGUT C KATIE PEPE M CUTRIGHT T J | 2004 | Environmental Pollution2004，131，： | 1 |
| 19 | Ototoxicity of the three xylene isomers in the rat显示文摘 | Katy M Robert L Pierre C | 2006 | Neurotoxicol Teratol2006，28，： | 1 |
| 20 | The effectiveness of the serum surfactant protein D(Sp-D) level to indicate lung injury in pulmonary embolism显示文摘 | Kati C Alaeam H Duran L | 2014 | Clin Lab2014，60，9： | 1 |
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