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| 1 | Leptin, cardiovascular diseases and type 2 diabetes mellitus显示文摘Leptin,经由胃口抑制在食物吸入的控制被含有的 adipokine,可以也刺激氧化应力,发炎,血栓,动脉的僵硬, angiogenesis 和 atherogenesis。这些导致 leptin 的效果可以预先安排到心血管的疾病的发展。在现在的评论,我们讨论与两个的存在,严厉或预后连接 leptin 层次的证据冠的动脉疾病和非心脏的脉管的疾病象中风那样,颈动脉动脉疾病,外部动脉疾病(垫)和象与长期的肾疾病( CKD )和类型一样的腹的大动脉的动脉瘤( AAA ) 2 糖尿病 mellitus ( T2DM )。Leptin 层次断然与存在,严厉,程度和冠的动脉粥样硬化以及与存在,严厉和 ischemic 和出血性的击的差的临床的结果的损害复杂性被联系了。但是冲突结果也存在。而且, leptin 被报导独立地预言普通颈动脉 intima 媒介厚度和颈动脉匾不稳定性。在 hyperleptinemia 和垫之间的一个连接被报导了,而有限数据在在 leptin 和 AAA 之间的潜在的协会上是可得到的。提高的 leptin 集中也象与胰岛素抵抗一样与 CKD 发生和前进有关, T2DM,微 -- 并且 macrovascular 糖尿病患者复杂并发症。Statins 和 antidiabetic 药(包括的 sitagliptin, metformin, pioglitazone, liraglutide 和 empagliflozin ) 可以影响 leptin 层次。进一步的研究被需要建立潜在的使用(如果任何) 是的 leptin 在这些疾病的一个治疗学的目标。 | Niki KATSIKI Dimitri P MIKHAILIDIS Maciej BANACH | 2018 | Acta Pharmacologica Sinica2018，39，7： | 41 |
| 2 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 3 | Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease:an update显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Niki Katsiki Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，，22： | 2 |
| 4 | Receiver operator characteristics and diagnostic value of progesterone and CA-125 in the prediction of ectopic and abortive intrauterine gestations 显示文摘 | Katsikis I Rousso D Farmakiotis D | 2006 | Eur J Obstet Gynecol Reprod Biol2006，125，2： | 1 |
| 5 | Pulmonary arterial hypertension and statins:an update显示文摘 | Katsiki N Wierzbicki AS Mikhailidis DP | 2011 | Curr Opin Cardiol2011，26，4： | 1 |
| 6 | Microstructural stability during low temperature exposure of alloys within the Al-Li-Cu-Mg system显示文摘 | Katsikis S Noble B Harris S J | 2008 | Materials Science and Engineering2008，485，12： | 1 |
| 7 | Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection 显示文摘 | Petrovas C Chaon B Amhrozak DR Price DA Melen- horst JJ Hill BJ Geldmacher C Casazza JP Chatto- padhyay PK Roederer M Douek DC Mueller YM Jacob- son JM Kulkarni V Felber BK Pavlakis GN Katsikis PD Koup RA | 2009 | J Immunol2009，183，2： | 1 |
| 8 | Surface ex- pression patterns of negative regulatory molecules identify determinants of virus-specific CD8 T-cell exhaustion in HIV infection 显示文摘 | Yamamoto T Price DA Casazza JP Ferrari G Nason M Chattopadhyay PK Roederer M Gostick E Katsikis PD Douek DC Haubrich R Petrovas C Koup RA | 2011 | Blood2011，117，18： | 1 |
| 9 | Study of the inhibitory effect of the product dihydroxyacetone on Gluconobacter oxydans in a semi-continuous two-stage repeated-fed-batch process显示文摘 | Bauer R Katsikis N Varga S | 2005 | Bioprocess and Biosystems Engineering2005，28，1： | 1 |
| 10 | Creatine phosphokinase in ectopic pregnancy revisited : significant diagnostic value of its MB and MM isoenzyme fractions 显示文摘 | Katsikis I Rousso D Farmakiotis D | 2006 | Am J Obstet Gynecol2006，194，1： | 1 |
| 11 | Imaging of apoptosis (programmed cell death) with ^99mTc-Annexin V显示文摘 | Blankenberg FG Katsikis PD Tait JF | 1999 | J Nucl Med1999，40，： | 1 |
| 12 | Immunoregulatory role of interleukin-10 in rheumatoid arthritis显示文摘 | Katsikis PD Chu CQ Brenman FM | 1994 | J Exp Med1994，179，： | 1 |
| 13 | Anti-miillerian hormone levels rdect severity of PCOS but are negtively influence by obesity relationship with increased luteinizing hormone levels显示文摘 | Piouka A Farmakiotis D Katsikis I | 2009 | Am J Physiol Endocrinol Metabol2009，296，2： | 1 |
| 14 | Re- ceiver operator characteristics and diagnostic value of pro- gesterone and CA-125 in the prediction of ectopic and a- bortive intrauterine gestations 显示文摘 | KATSIKIS I ROUSSO D FARMAKIOTIS D | 2006 | Eur J Obstet Gynecol Reprod Biol2006，125，2： | 1 |
| 15 | In vivo detection and imaging of phosphatidylserine expression during programmed cell death显示文摘 | Blankenberg FG Katsikis PD Tait JF | 1998 | Proc Natl Acad Sci U S A1998，95，： | 1 |
| 16 | Study of the inhibitory effect of the product dihydroxyacetone on Gluconobacter oxydans in a semi-continuous two-stage repeated-fed-batch process显示文摘 | BAUER R KATSIKIS N VARGA S | | 0，，01： | 1 |
| 17 | Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus显示文摘 | Niki Katsiki Dimitri P Mikhailidis Anna Gotzamani-Psarrakou John G Yovos Dimitrios Karamitsos | 2011 | Expert Opinion on Therapeutic Targets2011，，4： | 1 |
| 18 | In vivo detection and imaging of phosphatidylserine expression during programmed cell death显示文摘 | Blankenberg FG Katsikis PD TaitJF | 1998 | Proc Natl Acad Sci USA1998，95，11： | 1 |
| 19 | The role of insulin-sensi- tizing agents in the treatment of polycystic ovary syndrome显示文摘 | Katsiki N Georgiadou E Hatzitolios AI | 2009 | Drugs2009，69，11： | 1 |
| 20 | Adenomyosis: what is the impact on fertility? 显示文摘 | Matalliotakis IM Katsikis IK Panidis DK | 2005 | Curr Opin Obstet Gynecol2005，17，： | 1 |
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