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| 1 | Gastro-esophageal reflux disease symptoms are more common in general practice in Japan显示文摘AIM: To accurately assess the prevalence of GERD symptoms in general practice. METHODS: 4139 consecutive patients (2025 men and 2114 women with a mean age of 43 years), who fi rst attended the Outpatient Department of General Medicine and Emergency Care at Toho University Omori Hospital, were asked to respond to the F-scale questionnaire regardless of their chief complaints. The questionnaire is a self-report instrument, written in a simple and easy-to-understand language, containing 12 questions. RESULTS: Of 4139 subjects, 1554 patients (37.6%) were identifi ed as GERD according to their F-scale score (> 7). However, there were only 45 consultations (1.1%) for typical GERD symptoms. Although GERD symptoms are common in adults of all ages, the prevalence of GERD was highest in the 20-29 years age group and the age group 70-79 years had the lowest prevalence for both males and females. CONCLUSION: Although there was a high rate indicating GERD in our primary care population, only 1.1% of outpatients attended our hospital with a chief complaint of GERD symptoms. Since about one-third of GERD patients are affected by atypical symptoms, general physicians need to be cautious about extrapolating these results to patients with a chief complaint other than typical GERD symptoms. | Toshiyasu Watanabe Yoshihisa Urita Motonobu Sugimoto Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，31： | 12 |
| 2 | 保留C_2棘突半棘肌附着的颈椎管扩大椎板成形术显示文摘目的:观察完整保留C2棘突半棘肌附着的颈椎管扩大椎板成形术的手术疗效。方法:A组27例行改良颈椎板成形术,即显露时保留半棘肌在C2棘突上的附着,切除C3椎板,C4~C7双开门术式。B组33例行常规颈椎板成形术,即分离切断C2棘突半棘肌附着,关闭时缝合重建,C3~C7双开门成形术式。比较两组手术时间、出血量、术后神经功能、并发症、颈椎曲度和屈伸活动度(ROM)、病人自我评价。JOA计分法评价神经功能、Cobb’s法测量颈椎曲度和ROM。结果:所有病例随访至少1年,A、B组术后JOA评分平均改善率分别为63.01%、60.83%(P>0.05)。手术时间A、B组分别123±17.4min、175±12.7min,出血量分别380±18.6ml、564±21.5ml;A组较B组手术时间短、出血量少(P<0.05)。术后1年A、B组ROM分别保留术前的81.6%和65.3%(P<0.01);A组无后凸畸形、手术并发症少、局部症状轻微。结论:改良颈椎管扩大椎板成形术脊髓减压满意,手术时间短、出血量少,无严重并发症;而且有助于早期颈椎功能锻炼、维持良好颈椎曲度和ROM。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 廖威明 | 2006 | 中国临床解剖学杂志2006，24，5： | 9 |
| 3 | Phase Ⅱ study of protracted irinotecan infusion and a low-dose cisplatin for metastatic gastric cancer显示文摘AIM: To test protracted irinotecan infusion plus a low-dose cisplatin in this Phase Ⅱ trial to decrease its toxic-ity. METHODS: The eligibility criteria were: (1) histologi-cally proven measurable gastric cancer; (2) performance status of 0 or 1; (3) no prior chemotherapy or comple-tion of prior therapy at least 4 wk before enrollment; (4) adequate function of major organs; (5) no other active malignancy; and (6) written informed consent. The regi-men consisted of irinotecan (60 mg/m2) on d 1 and 15 by 24-h infusion and cisplatin (10 mg/m2) on d 1, 2, 3, 15, 16, and 17. Treatment was repeated every 4 wk. RESULTS: Thirty-one patients were registered between April 2000 and January 2001. The response rate for all 31 patients, 20 patients without prior chemotherapy, and 11 patients with prior chemotherapy was 52% (16/31), 60% (12/20), and 36% (4/11), respectively. The median survival time was 378 d. The median number of courses given to all patients was 2. Grade 4 neutropenia oc-curred in 11 (35%) patients, while grade 3 to 4 diarrhea or nausea occurred in 1 (3%) and 3 (10%) patients, respectively. Fatigue was minimal as grade 1 fatigue was found only in 3 (10%) patients. Other adverse events were mild and no treatment-related deaths occurred.CONCLUSION: This regimen showed a high level of ac-tivity and acceptable toxicity in patients with metastatic gastric cancer. | Hiroshi Imamura Masataka Ikeda Hiroshi Furukawa Toshimasa Tsujinaka Kazumasa Fujitani Kenji Kobayashi Hiroyuki Narahara Michio Kato Haruhiko Imamoto Arimichi Takabayashi Hideaki Tsukuma | 2006 | World Journal of Gastroenterology2006，12，40： | 7 |
| 4 | 陈国达矿(Ag9FeTe2S4):胶东地区金矿床中发现的硫碲化物新矿物显示文摘陈国达矿(Ag9FeTe2S4),产于中国胶东金矿区埠南金矿的含金-银的黄铜矿-石英脉中,呈5~70μm的半自形-他形粒状与方铅矿、黄铜矿、碲银矿、银金矿、自然银、未定名的Ag6TeS2,Ag16FeBiTe3S8共生,并被自然银和螺状硫银矿包围交代.其平均化学成分(16个EPMA分析值)为Ag8.97Fe1.00Te1.99S4.04,理想化学式Ag9FeTe2S4.利用甘多菲照相及同步辐射迴摆照相技术,获得陈国达矿的67个衍射线,主要衍射强线的d值和相对强度(括号中)为:6.742(69),6.416(39),5.951(33),3.265(100),2.981(24),2.649(22),2.25(24),2.188(71),2.142(22),2.123(31),2.044(23),1.949(33).该衍射数据指标化为斜方晶系,a=12.769(2),b=14.814(2),c=16.233(1),V=3070.63,Z=9,dcal=6.85g/cm3.反光显微镜下,陈国达矿的光学性质与硫银锡矿接近,浅灰色,无明显非均质性,摩氏硬度2~3,颜色指数:x=0.3027,y=0.3076,Y=25.78%,λd=474nm,Pe=3.68%.该矿物以中国地质学家、地洼学说的创立人陈国达教授的姓名命名.该矿物及命名经IMA-CNMMN于2004年投票通过.2005年作者补充数据后,由CNMMN主席正式公布,批准号2004-042a。 | 谷湘平 WATANABE Makoto 谢先德 彭省临 NAKAMUTA Yoshihiro OHKAWA Makio HOSHINO Kenichi OHSUMI Kazumasa SHIBATA Yasuhiro | 2008 | 科学通报2008，53，17： | 7 |
| 5 | Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma显示文摘AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion. | Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 6 | 前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤的疗效比较显示文摘目的比较前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤的临床疗效。方法回顾性分析2000年8月~2005年10月采用前路减压、椎体间融合内固定(A组,n=11)和后路短缩截骨术(B组,n=14)治疗的骨质疏松性胸腰椎骨折合并神经损伤患者的临床和影像学资料。疼痛视觉模拟评分及日本整形外科学会评分法评估临床结果,Frankel分级评价神经功能,X线片评估融合及后凸矫正,并观察手术并发症。结果所有患者得到14~48个月(平均27个月)随访,末次随访A、B两组疼痛视觉模拟评分分别由术前9.3、8.9分减少到3.2、2.5分;JOA评分及其平均恢复率两组差异无统计学意义(P〉0.05);Frankel分级A、B组分别6例、5例由术前C级恢复到D或E级,5例、9例由D级恢复到E级,分别改善1.5、1.7级;A、B组后凸角分别由术前平均36.9°、37.3°矫正到术后9.3°、6.5°和末次随访的14.5°、11.7°,术后两组差异有统计学意义(P〈0.05)。两组均无内固定相关并发症。结论前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤临床疗效无显著差异;对于后凸角度较大者,宜选择后路短缩截骨术。 | 龙厚清 Kazumasa Ueyama 刘少喻 黄阳亮 陈立言 李佛保 | 2007 | 中华创伤骨科杂志2007，9，9： | 5 |
| 7 | Efects of amine, amine salt and amide on the behaviour of carbon dioxide absorption into calcium hydroxide suspension to precipitate calcium carbonate显示文摘The amount of carbon dioxide(CO2) absorption and calcium ion(Ca2+) concentration besides the pH of aqueous solution were observed during the CO2 absorption to precipitate calcium carbonate(CaCO3) from calcium hydroxide(Ca(OH)2). A reaction rate-limiting efect of an amount of CO2 absorption without any organic additives in the early stage of the precipitation was observed, which was attributed to an interruption efect of bicarbonate ion(HCO 3) on the precipitation of CaCO3. The improvement for the reaction rate was achieved not only by amine additives but also by neutral additives such as ε-caprolactam or amine salt. When the hexamethylene diamine was dissolved in the solution, successive change of crystal forms of CaCO3 aragonite to calcite in aqueous suspensions, confirmed by Ca2+ concentration change and X-ray difraction, was concluded that a local environment around the amine group in aqueous solution and an interaction of the diamine with precipitated CaCO3 particles were important factors for these reactions. | Wittaya Chuajiw Mitsuru Nakano Kazumasa Takatori Toshiya Kojima Yoshiki Wakimoto Yoshiaki Fukushima | 2013 | Journal of Environmental Sciences2013，25，12： | 5 |
| 8 | 后路短缩截骨内固定治疗骨质疏松性症状性陈旧胸腰椎骨折显示文摘目的:观察后路短缩截骨内固定治疗骨质疏松性症状性陈旧胸腰椎骨折的疗效。方法:回顾18例后路短缩截骨内固定治疗的陈旧性骨质疏松性胸腰椎骨折患者的临床和影像学资料,平均年龄67岁。T12、L1、L2节段分别为8例、5例、5例,其中骨折不愈合4例,后凸畸形并神经功能障碍11例,爆裂骨折合并神经压迫保守治疗无效3例。应用疼痛视觉模拟(VAS)评分及JOA评分法评估临床结果,Frankel分级评价神经功能状态,X线评估融合及后凸状况,并观察手术并发症。结果:平均手术时间213min,平均出血量780ml。随访27个月(19~48个月),末次随访时VAS评分由术前8.9分减少到2.5分,JOA评分(25.1±4.1分)显著优于术前(12.7±3.6分,P<0.001);Frankel分级5例由术前C级恢复到D或E级,9例由D级恢复到E级;平均后凸角由术前37.3°矫正到术后6.5°,末次随访时为13.7°。无内固定相关并发症。结论:后路短缩截骨内固定是治疗骨质疏松性症状性陈旧胸腰椎骨折的有效方法,但应严格手术指征。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 廖威明 | 2006 | 中国脊柱脊髓杂志2006，16，10： | 4 |
| 9 | Erythropoietin gene transfer into rat testes by in vivo electropo-ration may reduce the risk of germ cell loss caused by cryptorchidism显示文摘瞄准:由借助于在活体内 electroporation 把老鼠 Epo 基因变成地窟兰花睾丸在精子发生上调查老鼠红细胞生成素(Epo ) 的效果。方法:有通过手术导致的单方的隐睾病的 Sprague-Dawley 老鼠被划分成三个组:第一个组被给 pCAGGS-Epo (pCAGGS-Epo 组) 的睾丸内注射,第二个组被给 pCAGGS (pCAGGS 组) 的睾丸内注射,并且第三个组是给定的睾丸内注射缓冲磷酸盐 saline (PBS 组) 。同时, 30 V 的方形的电的脉搏与 100 ms 的一个时间常数被使用六次。在注射以后的一或二个星期,每个睾丸被称,总数的比率生殖细胞数到 Sertoli 房间(G/S 比率) 的被计算评估精子发生的缺陷。从每三个组拿的十个睾丸被检验在每次指。结果:在 pCAGGS-Epo 或 pCAGGS 控制原生质标志的注射以后的阴囊的重量是(0.85+/-0.08 ) g 并且(0.83+/-0.03 ) g,分别地在星期 1 点(P = 0.788 ) 并且(0.62+/-0.06 ) g 并且(0.52+/-0.02 ) g,分别地在星期 2 点(P = 0.047 ) 。在星期 1 点, spermatids 和精子比在控制睾丸的那些更充满有 pCAGGS-Epo 的睾丸。在星期 2 点, spermatids 和精子几乎没在任何一个组被检测。G/S 比率在星期 1 点是 23.27 +/-6.80 对 18.63+/-5.30 (P = 0.0078 ) 并且在星期 2 点的 7.16+/-3.06 对 6.05+/-1.58 (P = 0.1471 ) 分别地。结论:到由在活体内 electroporation 的老鼠睾丸的 Epo 的转移可以减少隐睾病引起的细菌房间损失的风险。 | Masaki Dobashi Kazumasa Goda Hiroki Maruyama Masato Fujisawa | 2005 | Asian Journal of Andrology2005，7，4： | 3 |
| 10 | New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0显示文摘AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3,and simultaneous determination of HCV viral load using commercial Amplicor GT HCV MONITOR test v2.0 (microwell version).METHODS: The HCV Guideline test used the PCR product generated in commercial Amplicor GT HCV Monitor test v2.0 for viral load measurement using microwell plate version of Amplicor HCV Monitor and also captured on separate plates containing capture probes and competitive oligonucleotide probes specific for HCV genotypes 1, 2 and 3, The HCV genotype was subsequently determined using the biotin-labeled PCR product and five biotin-labeled HCV-specific probes.RESULTS: The sensitivity of the HCV Guideline test was 0.5 KIU/mL. Specificity of the HCV Guideline test was confirmed by direct sequencing of HCV core region and molecular evolutionary analyses based on a panel of 31 samples. The comparison of the HCV Guideline test and an in-house HCV core genotyping assay using 252 samples from chronic hepatitis C patients indicated concordant results for 97.2% of samples (59.5% genotype 1, 33.7% genotype 2, 6.0% genotype 3, and 0.8% mixed genotypes).Similarly, the HCV Guideline test showed concordance with a serological test, and the serological test failed to assign any serotype in 12.7% of the samples, indicating a better sensitivity of the HCV Guideline test.CONCLUSION: Clinically, both viral load and genotypes (1, 2 and 3) have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C based on guidelines and they are, in normal circumstances,performed as separate stand-alone assays. The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C. | Motokazu Mukaide Yasuhito Tanaka Hirokazu Kakuda Kei Fujiwara Fuat Kurbanov Eturo Orito Kentaro Yoshioka Kiyotaka Fujise Shoji Harada Takazumi Kozaki Kazuo Takemura Kazumasa Hikiji Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，4： | 3 |
| 11 | 后路非融合固定在腰椎间盘退变性疾病中的临床应用显示文摘目的 评估后路非融合固定(Graf技术)应用于腰椎间盘退变性疾病的疗效。方法分析13例非融合固定(A组)和21例融合固定(B组)治疗单节段腰椎退行性病变的临床和影像学资料。视觉模拟评分(VAS)、日本整形外科学会(JOA)评分和ODI功能评价评估临床疗效,腰椎过伸和过屈、侧位X线片评估腰椎活动度和腰椎前凸角(Cobbs法),观察两组手术并发症。结果 平均随访19个月(12~29个月),末次随访A、B两组VAS评分分别由术前9.4、9.1分减少到2.1、3.6分;JOA评分均显著优于术前(P〈0.001),两组无显著性差异(P〉0.05);A组术后ODI优良率93%,B组71%,A组显著优于B组(P〈0.05)。结论 后路非融合固定是治疗腰椎间盘退变性疾病的有效方法,与融合固定相比,可以获得满意的临床疗效和保留一定的腰椎活动度。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 廖威明 | 2008 | 中国骨与关节损伤杂志2008，23，6： | 3 |
| 12 | Hydrodesulfurization of coal tar pitch using Pt/Al_(2)O_(3)and Pd/Al_(2)O_(3)catalysts under mild conditions显示文摘Hydrodesulfurization(HDS)of coal tar pitch(CTP)using Pt/Al_(2)O_(3)and Pd/Al_(2)O_(3)catalysts in tetrahydrofuran at 333 K and atmospheric pressure was investigated.The HDS of dibenzothiophene(DBT)proceeded over both the Pt and Pd catalysts under the mild conditions.The effects of polycyclic aromatic hydrocarbons on the HDS of DBT were examined:a naphthalene ring suppressed the HDS,while a benzene ring did not.CTP underwent HDS as well as partial hydrogenation under the mild conditions.The Pt catalyst was more active than the Pd catalyst in the HDS of CTP.The sulfur content in CTP was reduced by over 50%through the HDS process. | Kazumasa Yazu Atul Sharma | 2019 | Carbon Resources Conversion2019，2，3： | 3 |
| 13 | Serum pepsinogens as a screening test of extensive chronic gastritis显示文摘 | Kazumasa Miki M.D. Masao Ichinose M.D. Akihiro Shimizu M.D. Shih Che Huang M.D. Hiroshi Oka M.D. Chie Furihata Ph.D. Taijiro Matsushima Ph.D. Kenji Takahashi Ph.D | 1987 | Gastroenterologia Japonica1987，，2： | 2 |
| 14 | Gastric cancer screening using the serum pepsinogen test method显示文摘 | Kazumasa Miki | 2006 | Gastric Cancer2006，，4： | 2 |
| 15 | Preserving the C7 spinous process with its muscles attached: effect on axial symptoms after cervical laminoplasty显示文摘 | Kenji Kowatari Kazumasa Ueyama Akio Sannohe Yoshihito Yamasaki | 2009 | Journal of Orthopaedic Science2009，，3： | 2 |
| 16 | Dermal absorption of mucopolysaccharide polysulfate (heparinoid) in human and minipig显示文摘 | Tadao Kumokawa Kazumasa Hirata Keiichi Sato Satoshi Kano | 2011 | Arzneimittelforschung2011，，02： | 2 |
| 17 | 限制性和动力性颈椎前路钢板对颈椎矢状位曲度的影响显示文摘目的:比较限制性(Constrained)和动力性(Dynamic)颈椎前路钢板融合率、对融合节段及全颈椎矢状面曲度影响。方法:回顾分析97例(C组59例;D组38例)颈椎前路钢板内固定术后的影像学资料,Cobb's法测量颈椎侧位X线片上融合节段和C3~C7矢状位曲度、融合节段前柱高度,比较其术后即刻及随访末期参数的变化。连续骨小梁通过融合区、X线动态侧位片显示融合节段棘突顶点间距离无变化判定为融合。结果:平均随访16.9个月,C、D组融合率分别为91.6%、97.3%。C组融合节段前凸角丢失单节段为1.17°(0~2.9°)、双节段为1.83°(0~3.5°),D组单节段2.57°(0.5°~4.9°)、双节段3.59°(1°~6.1°),两组有显著性差别(P<0.001)。C、D两组全颈椎矢状面曲度术后和随访末比较无显著差异。C组融合节段前柱高度丢失单节段为1.39mm(0.4~2.9mm)、双节段2.37mm(0.6~4.7mm);D组单节段高度丢失为1.77mm(0.7~3.1mm)、双节段为3.54mm(0.9~5.5mm),与C组相比无显著性差异(P>0.05)。结论:动力性颈椎前路钢板可获得较高的融合率,与限制性钢板相比,融合节段前凸角丢失和前柱高度丢失虽然较大,但不影响整个颈椎的前凸角度。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 | 2008 | 中国临床解剖学杂志2008，26，5： | 2 |
| 18 | Helicobacter pylori Infection and Gastric Cancer (A Nested Case-Control Study in a Rural Area of Japan)显示文摘 | Yoshiyuki Watanabe John H. Kurata Shigeto Mizuno Masako Mukai Hideto Inokuchi Kazumasa Miki Kotaro Ozasa Keiichi Kawai | 1997 | Digestive Diseases and Sciences1997，，7： | 2 |
| 19 | Autoxidation of Phosphatidyl-ethanolamine and Phosphatidylcholine in Organic Solvents显示文摘 | Kazumasa Y Koji U Tetsuo N | 1992 | Yukagaku1992，41，7： | 1 |
| 20 | Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings显示文摘 | Kazumasa Hayasaka Kazuo Morita Tomoya Saitoh Yoshiaki Tanaka | 2006 | Computerized Medical Imaging and Graphics2006，，： | 1 |
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