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| 1 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 2 | Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment显示文摘 | Shuping Zhang | 2015 | Cellular & Molecular Immunology2015，12，5： | 17 |
| 3 | The functional analysis of OsTDF1 reveals a conserved genetic pathway for tapetal development between rice and Arabidopsis显示文摘在花药开发期间, tapetum 为花粉开发提供材料和营养素。在 Arabidopsis,几个抄写因素被识别了为 tapetal 开发和功能形成一条基因小径(DYT1TDF1AMSMS188MS1 ) 。在 TAPETAL 开发和 FUNCTION1 (TDF1 ) 的有缺陷者是 R2R3 MYB 家庭的一个成员并且为在 Arabidopsis 的早 tapetum 开发是必要的。这里,我们在米饭描绘了 Arabidopsis TDF1 的 ortholog, OsTDF1 (LOC_Os03g18480 ) 。OsTDF1 分享 69 ? 有在 N 终端区域附近的通常认为的 MYB 领域的 AtTDF1 的 % 氨基酸顺序身份。RT-PCR 并且在 situ 杂交表演,那 OsTDF1 明确地在米饭花药的 tapetal 房间被表示。在 Arabidopsis tdf1 异种的 OsTDF1 的表达式恢复它的富饶,建议这个相当或相同的事物能完成在 Arabidopsis 的 TDF1 的正常函数。ostdf1 大美人异种展出男性无菌的显型。它的 tapetal 房间展出类似于 Arabidopsis tdf1 异种的 vacuolated 和 hypertrophic 显型。终端 deoxynucleotidyl 当为 tapetum 的一个必要管理者规划了房间死亡,把试金标记的调停 transferase 的 dUTP 刻痕结束揭示了 OsTDF1 行为。qRT-PCR 分析表明 OsTDF1 UDT1 下游地行动,建议为 tapetum 开发的基因小径通常在米饭和 Arabidopsis 之间被保存并且在米饭的 TDR, EAT1, OsMYB103 和 PTC1 在上游。 | Ci-Feng Cai Jun Zhu Yue Lou Zong-Li Guo Shuang-Xi Xiong Ke Wang Zhong-Nan Yang | 2015 | Science Bulletin2015，60，12： | 13 |
| 4 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 5 | Activation of Toll-like receptors signaling in non-small cell lung cancer cell line induced by tumor-associated macrophages显示文摘Background:Inflammation is often linked with the progress and poor outcome of lung cancer.The understanding of the relationship between tumor-associated macrophages(TAMs) and lung cancer cells involves in the underlying mechanism of inflammatory cytokine production.Toll-like receptors(TLRs) are engaged in promoting the production of pro-inflammatory cytokines and play an important role in tumor immunology.Methods:To investigate the mechanisms by which TAMs influence the production of pro-inflammatory cytokines in lung cancer cells,we established an in vitro coculture system using TAMs and human nonsmall cell lung cancer(NSCLC) cell line SPC-A1.Levels of interleukin(IL)-1β,IL-6 and IL-8 in SPC-A1 were evaluated by RT-PCR and cytometric bead array assay after being cocultured with TAMs.Expression changes of TLRs and TLRs signaling pathway proteins in SPC-A1 were further confirmed by RT-PCR and western blot.The level changes of IL-1β,IL-6 and IL-8 in SPC-A1 were also detected after the stimulation of TLRs agonists.Results:We found that the phenotype markers of TAMs were highly expressed after stimulating human monocyte cell line THP-1 by phorbol-12-myristate-13-acetate(PMA).Higher mRNA and supernate secretion levels of IL-1β,IL-6 and IL-8 were detected in SPC-A1 after being cocultured with TAMs.We also found that TLR1,TLR6 and TLR7 were up-regulated in SPC-A1 in the coculture system with TAMs.Meanwhile,TLRs signaling pathway proteins were also significantly activated.Moreover,pre-treatment with agonist ligands for TLR1,TLR6 and TLR7 could dramatically promote inductions of IL-1β,IL-6 and IL-8.Conclusions:These findings demonstrated that TAMs may enhance IL-1β,IL-6 and IL-8 expressions via TLRs signaling pathway.We conclude that TAMs contribute to maintain the inflammation microenvironment and ultimately promote the development and progression of lung cancer. | Xing Ke Meng Wu Jianfang Lou Shuping Zhang Peijun Huang Ruihong Sun Lei Huang Erfu Xie Fang Wang Bing Gu | 2015 | Chinese Journal of Cancer Research2015，27，2： | 6 |
| 6 | 供水系统中冲刷对金属管道内壁生物膜脱落的影响作用(英文)显示文摘目的:在市政供水管网系统中,由冲刷引起的管道内壁生物膜脱落可能造成饮用水二次污染。本文旨在通过研究冲刷前后生物膜理化特性和微生物种群结构的变化,探讨不同金属管材管道和不同冲刷流速对生物膜脱落的影响,从而为管道生物安全的风险评估提供科学依据。创新点:不同菌属的细菌对水力冲刷的敏感程度不同;各菌属对水力变化的敏感程度既与菌属本身的性质有关,也与其附着生长的管材有关。方法:1.采用R2A培养基平板计数、16S rD NA检测、荧光定量聚合酶链式反应及454焦磷酸测序技术。2.通过理化指标检测与测序相结合的方式进行分析,并以丰度图和热度图的形式呈现结果。结论:1.球墨铸铁管内壁生物膜的抗水力剪切能力较强,能够抵抗低剪切冲刷,在高剪切力冲刷后才会明显脱落,而灰口铸铁管和不锈钢复合管内壁生物膜的抗水力剪切能力较弱,低剪切力冲刷工况便会导致生物膜的明显脱落。2.生物膜对冲刷的抵抗作用在其群落的属水平和纲水平上有显著变化,这与群落本身和管材特性均有关联。 | Jing-qing LIU Zhi-feng LUO Ke LIU Yi-fu ZHANG Hong-xi PENG Bao-lan HU Hong-xing REN Xiao-yan ZHOU Shang-de QIU Xiao-fang HE Ping YE Hamid BASTANI Li-ping LOU | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，4： | 5 |
| 7 | Diagnosis of Early Esophageal Cancer Based on TCM Tongue Inspection显示文摘Esophageal cancer is a common malignant carcinoma that occurs in the digestive tract and leads to around three million deaths worldwide.Patients commonly present with symptoms,such as dysphagia,cough,hoarseness,and pain in the esophagus.According to researches,smoking,alcohol consumption,exposure to radiation,contaminated food,chronic throat irritation,consumption of extremely hot beverages,genetic mutation,and dystrophia are influential factors in the development of esophageal carcinoma[1]. | SONG An Yi LOU Yan Ni YANG Qian Xi LI Dong Fang SONG Guo Hui HUANG Lai Qiang YUAN Ke Hong JIA Li Qun | 2020 | Biomedical and Environmental Sciences2020，33，9： | 5 |
| 8 | Neocartilage formation from predifferentiated human adipose derived stem cells in vivo显示文摘目的:在 vitro 由人的转变生长因素 beta2 ( hTGF beta2 )导致了检验人的脂肪质的导出的干细胞( hASC )的 chondrogenic 潜力,并且到 predifferentiated hASC 能生产的 investigateif ,在 vivo.Methods:hASC 的 neocartilage 是孤立的 fromsubcutaneous 脂肪质的织物并且在有 hTGF beta2.Chondrogenicdifferentiation 的增加的小团有教养是由 RT-PCR 的 assayed ,西方的弄污,染色的 toluidine 蓝色,为骨胶原类型 II.For 染色的andimmuno组织化学在里面 vivo | Xiao-bing JIN Yong-sheng SUN Ke ZHANG Jing WANG Xiao-dong JU Si-quan LOU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 5 |
| 9 | Lijiang 2.4-meter Telescope and its instruments显示文摘The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational conditions.During its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized. | Chuan-Jun Wang Jin-Ming Bai Yu-Feng Fan Ji-Rong Mao Liang Chang Yu-Xin Xin Ju-Jia Zhang Bao-Li Lun Jian-Guo Wang Xi-Liang Zhang Mei Ying Kai-Xing Lu Xiao-Li Wang Kai-Fan Ji Ding-Rong Xiong Xiao-Guang Yu Xu Ding Kai Ye Li-Feng Xing Wei-Min Yi Liang Xu Xiang-Ming Zheng Yuan-Jie Feng Shou-Sheng He Xue-Li Wang Zhong Liu Dong Chen Jun Xu Song-Nian Qin Rui-Long Zhang Hui-Song Tan Zhi Li Ke Lou Jian Li Wei-Wei Liu | 2019 | Research in Astronomy and Astrophysics2019，19，10： | 4 |
| 10 | THE THEORETICAL STUDIES OF PRODUCT ALIGNMENT OF THE REACTIONS OF Na,F WITH CH_3I显示文摘The NaI and IF product rotational alignment of the reactionsof Na,F+CH3I has been theoretically studied in a LEPS PES.Theproduct alignment versus the relative translational energy of the reactantshas been obtained. | Ke Li HAN Guo Zhong HE Nan Quan LOU State Key Laboratory of Molecular Reaction Dynamics,Dalian Institute of Chemical Physics,CAS,Dalian 116012,China | 1993 | Chinese Chemical Letters1993，4，6： | 3 |
| 11 | Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies显示文摘PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer. | WANG YanFang SHI Lin SONG QuanSheng ZHANG YingMei LOU YaXin ZHENG Yi MA DaLong WANG Ying KE XiaoYan | 2009 | Chinese Science Bulletin2009，54，21： | 3 |
| 12 | New Result on Delay-dependent Stability for Markovian Jump Time-delay Systems With Partial Information on Transition Probabilities显示文摘This paper focuses on the delay-dependent stability for a kind of Markovian jump time-delay systems(MJTDSs),whose transition rates are incompletely known. In order to reduce the computational complexity and achieve better performance,auxiliary function-based double integral inequality is combined with extended Wirtinger's inequality and Jensen inequality to deal with the double integral and the triple integral in augmented Lyapunov-Krasovskii function(ALKF) and their weak infinitesimal generator respectively, the more accurate approximation bounds with a fewer variables are derived. As a result, less conservative stability criteria are proposed in this paper. Finally,numerical examples are given to show the effectiveness and the merits of the proposed method. | Yan Zhang Ke Lou Yuan Ge | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 3 |
| 13 | Spatial distribution, environmental risks, and sources of potentially toxic elements in soils from a typical abandoned antimony smelting site显示文摘The rapid development of the smelting industry increases the release of antimony(Sb)into the soil environment,which threatens human health and ecosystems.A total of 87 samples were collected from an abandoned Sb smelting site to evaluate pollution characteristics and environmental risks of the potentially toxic elements(PTEs).The contents of As,Cu,Ni,Pb,Sb,and Zn in the fresh soils determined by P-XRF were 131,120,60,145,240,and 154 mg/kg,respectively,whilst following drying,grinding,and sieving pretreatments,the corresponding contents increased to 367,179,145,295,479,and 276 mg/kg,respectively.There was a significant correlation between the data obtained by P-XRF and ICP-OES in the treated samples,which showed the application feasibility of P-XRF.The average contents of Sb and As were 440.6 and 411.6 mg/kg,respectively,which exceeded the control values of the development land in GB 36600-2018.The ecological risk levels of the six PTEs decreased in the following order:As>Sb>Pb>Zn>Ni>Cu.Non-carcinogenic risk revealed that As,Pb,and Sb posed health risks for children,whilst for carcinogenic risk,the risk values for As and Ni were higher than the limit values for both children and adults.Anthropogenic sources accounted for more than 70.0%of As,Pb,and Sb concentrations in soils,indicating a significant influence on PTEs accumulation.The findings provide a basis for quick determination of the contamination characteristics and risk control of PTEs at Sb smelting sites. | Shengguo Xue Ramon Korna Jiarong Fan Wenshun Ke Wei Lou Jinting Wang Feng Zhu | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 14 | Transcriptional expression of glioma chemotherapy drugs associatedmarker molecules in gliomas and normal brain tissues显示文摘 | Yaodong Zhao Yajun Xue Quanbin Zhang Ke Wang Jia Yin Meiqing Lou | 2013 | Cancer Biomarkers2013，，1： | 1 |
| 15 | Effect of All-Trans Retinoic Acid on the Differentiation of U87 Glioma Stem/Progenitor Cells显示文摘 | Zhe Shi Meiqing Lou Yaodong Zhao Quanbin Zhang Daming Cui Ke Wang | 2013 | Cellular and Molecular Neurobiology2013，，7： | 1 |
| 16 | Effect of magnetic field distribution on ECR ion source discharge显示文摘An electron cyclotron resonance ion source model that uses a coaxial antenna to inject the RF power was simulated, and the corresponding hydrogen plasma densities of the ion source were calculated at different magnetic field distributions via a fluid model. The results show that most of the microwave power is absorbed around the resonance surface near the antenna when the plasma density is below the cutoff density of 7.4 × 10^(16) m^(-3) for 2.45 GHz microwaves, and the simulation results also show that the plasma density is strongly influenced by the position and shape of the resonance surface, where a larger resonance surface would improve the plasma density. | Yu-Guo Liu Jian-Lin Ke Guang-Yi Zhao Ben-Chao Lou Yong-Hong Hu Rong Liu | 2018 | Nuclear Science and Techniques2018，29，9： | 1 |
| 17 | Dual-mode protein detection based on Fe3O4-Au hybrid nanoparticles显示文摘 | Lou Lei Yu Ke Zhang Zhengli | 2012 | Nano Research2012，5，4： | 1 |
| 18 | Negative Capacitance In- duced by Redistribution of Oxygen Vacancies in the Fatigued BiFeO3-based Thin Film 显示文摘 | Ke Q Q Lou X J Yang H B | 2012 | Applied Physics Letters2012，101，02： | 1 |
| 19 | Origin of the Enhanced Po- larization in La and Mg Co-Substituted BiFeO3 Thin Film during the Fatigue Process 显示文摘 | Ke Q Q Kumar A Lou X J | 2012 | Applied Physics Letters2012，100，04： | 1 |
| 20 | Panicle-3D:Efficient Phenotyping Tool for Precise Semantic Segmentation of Rice Panicle Point Cloud显示文摘The automated measurement of crop phenotypic parameters is of great significance to the quantitative study of crop growth.The segmentation and classification of crop point cloud help to realize the automation of crop phenotypic parameter measurement.At present,crop spike-shaped point cloud segmentation has problems such as fewer samples,uneven distribution of point clouds,occlusion of stem and spike,disorderly arrangement of point clouds,and lack of targeted network models.The traditional clustering method can realize the segmentation of the plant organ point cloud with relatively independent spatial location,but the accuracy is not acceptable.This paper first builds a desktop-level point cloud scanning apparatus based on a structured-light projection module to facilitate the point cloud acquisition process.Then,the rice ear point cloud was collected,and the rice ear point cloud data set was made.In addition,data argumentation is used to improve sample utilization efficiency and training accuracy.Finally,a 3D point cloud convolutional neural network model called Panicle-3D was designed to achieve better segmentation accuracy.Specifically,the design of Panicle-3D is aimed at the multiscale characteristics of plant organs,combined with the structure of PointConv and long and short jumps,which accelerates the convergence speed of the network and reduces the loss of features in the process of point cloud downsampling.After comparison experiments,the segmentation accuracy of Panicle-3D reaches 93.4%,which is higher than PointNet.Panicle-3D is suitable for other similar crop point cloud segmentation tasks. | Liang Gong Xiaofeng Du Kai Zhu Ke Lin Qiaojun Lou Zheng Yuan Guoqiang Huang Chengliang Liu | 2021 | Plant Phenomics2021，3，1： | 1 |
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