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| 1 | Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma显示文摘AIM To investigate the expression and prognostic role of programmed death ligand-1(PD-L1) in locally advanced esophageal squamous cell carcinoma(ESCC).METHODS A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met. Medical records were reviewed retrospectively to assess clinical outcomes. Patients were divided into two groups by PD-L1 status, and significant differences in clinicopathologic characteristics between the two groups were assessed. RESULTS Tumor tissues from 67 ESCC patients(33.5%) were PDL1-positive. Positive p16 expression was observed in 21 specimens(10.5%). The H-score for c-Met expression was ≥ 50 in 42 specimens(21.0%). Although PDL1-positivity was not significantly correlated with any clinical characteristics including age, sex, smoking/alcoholic history, stage, or differentiation, H-scores for c-Met expression were significantly associated with PDL1-positivity(OR = 2.34, 95%CI: 1.16-4.72, P = 0.017). PD-L1 expression was not significantly associated with a change in overall survival(P = 0.656). In contrast, the locoregional relapse rate tended to increase(P = 0.134), and the distant metastasis rate was significantly increased(HR = 1.72, 95%CI: 1.01-2.79, P = 0.028) in patients with PD-L1-positive ESCC compared to those with PD-L1-negative ESCC.CONCLUSION PD-L1 expression is positively correlated with c-Met expression in ESCC. PD-L1 may play a critical role in distant failure and progression of ESCC. | Ryul Kim Bhumsuk Keam Dohee Kwon Chan-Young Ock Miso Kim Tae Min Kim Hak Jae Kim Yoon Kyung Jeon In Kyu Park Chang Hyun Kang Dong-Wan Kim Young Tae Kim Dae Seog Heo | 2016 | World Journal of Gastroenterology2016，22，37： | 14 |
| 2 | Spotlight on almotriptan in migraine显示文摘 | Keam SJ Goa KL Figgitt DP | 2002 | CNS Drug2002，16，7： | 1 |
| 3 | Eseitalopram : a review of its use in the management of major depressive disorder显示文摘 | Murdoeh D Keam SJ | 2005 | Drugs2005，65，： | 1 |
| 4 | Tribological behavior of candidate coatings for AI die casting dies 显示文摘 | Salas O Keams K Carrera S | 2003 | Surface and Coatings Technology2003，172，： | 1 |
| 5 | Prognostic impact of clinicopathologic parameters in stage Ⅱ / Ⅲ breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer显示文摘 | Keam B Im S A Kim H J | 2007 | BMC Cancer2007，1，： | 1 |
| 6 | Dasatinib:In chronic myeloid leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘 | Keam S J | 2008 | Biodrugs2008，22，1： | 1 |
| 7 | Ki-67 can he used for further classification of triple negative breast cancer into two subtypes with different response and prognosis 显示文摘 | Keam B Lee KH Han SW | 2011 | Breast Cancer Research2011，13，2： | 1 |
| 8 | Clinical Usefulness of AJCC Response Criteria for Neoadjuvant Chemotherapy in Breast Cancer显示文摘 | Keam B Im SA | 2013 | Ann SurgOncol2013，20，7： | 1 |
| 9 | Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy显示文摘 | Keam B Im SA Koh Y | 2011 | BMC Cancer2011，11，： | 1 |
| 10 | Actinomycosis in obstructive tonsillar hypertrophy and recurrent tonsillitis显示文摘 | Pransky SM Feldman JI Keams DB | 1991 | Arch Otolarypgol Head Neck Surg1991，117，8： | 1 |
| 11 | Relationship between low bone mineral density and exercise- induced myocardial Ischemia显示文摘 | From AM Hyder JA Keams AE | 2007 | Mayo Clin Proc2007，82，： | 1 |
| 12 | A review of its use as maintenance therapy in patients with COPD显示文摘 | Keam SJ Keat GM Tiotropiu BM | 2004 | Treat Respir Med2004，3，4： | 1 |
| 13 | Prognoslie impact of elinicopath- ologic parameters in stage 1I/III breast cancer treated with neoadju- rant docetaxeland doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer 显示文摘 | Keam B Im SA Kim HJ | 2007 | BMC Cancer2007，7，： | 1 |
| 14 | The Adheaive Mechanism of the Monogenean Parasite Tetraonchus Monoenteron from the Gills of the Pike( Esox lucius)显示文摘 | Keam GC | 1966 | Parasit1966，56，4： | 1 |
| 15 | Social cohesion social capital and the neighborhood 显示文摘 | Forrest R Keams A | 2001 | Urban Studies2001，38，： | 1 |
| 16 | Almotriptan,a review of its use in migraine显示文摘 | KEAM SJ GOA KL FIGGITT DP | 2002 | Drugs2002，62，2： | 1 |
| 17 | Dasatinib:a review of its use in the treatment of chronic myeloid leukaemia and Philadelphia chromosomepositive acutelymphoblasticleukaemia显示文摘 | McCormack PL Keam SJ | | 0，，13： | 1 |
| 18 | Nasal dermoids显示文摘 | Zapata S Keams DB | 2006 | Curr Opin Otolaryngol HeadNeck Surg2006，14，6： | 1 |
| 19 | DDS,4,4'-diaminodi- phenylsulfone,extends organismic lifespan显示文摘 | Cho S C Park M C Keam B | 2010 | Proceedings of the National Academy of Sciences2010，107，19： | 1 |
| 20 | Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis 显示文摘 | Bhumsuk Keam Seoek-Ah Im Kyung-Hun Lee et al | 2011 | Breast Cancer Research2011，13，： | 1 |
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