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| 1 | Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma显示文摘AIM To investigate the expression and prognostic role of programmed death ligand-1(PD-L1) in locally advanced esophageal squamous cell carcinoma(ESCC).METHODS A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met. Medical records were reviewed retrospectively to assess clinical outcomes. Patients were divided into two groups by PD-L1 status, and significant differences in clinicopathologic characteristics between the two groups were assessed. RESULTS Tumor tissues from 67 ESCC patients(33.5%) were PDL1-positive. Positive p16 expression was observed in 21 specimens(10.5%). The H-score for c-Met expression was ≥ 50 in 42 specimens(21.0%). Although PDL1-positivity was not significantly correlated with any clinical characteristics including age, sex, smoking/alcoholic history, stage, or differentiation, H-scores for c-Met expression were significantly associated with PDL1-positivity(OR = 2.34, 95%CI: 1.16-4.72, P = 0.017). PD-L1 expression was not significantly associated with a change in overall survival(P = 0.656). In contrast, the locoregional relapse rate tended to increase(P = 0.134), and the distant metastasis rate was significantly increased(HR = 1.72, 95%CI: 1.01-2.79, P = 0.028) in patients with PD-L1-positive ESCC compared to those with PD-L1-negative ESCC.CONCLUSION PD-L1 expression is positively correlated with c-Met expression in ESCC. PD-L1 may play a critical role in distant failure and progression of ESCC. | Ryul Kim Bhumsuk Keam Dohee Kwon Chan-Young Ock Miso Kim Tae Min Kim Hak Jae Kim Yoon Kyung Jeon In Kyu Park Chang Hyun Kang Dong-Wan Kim Young Tae Kim Dae Seog Heo | 2016 | World Journal of Gastroenterology2016，22，37： | 14 |
| 2 | Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans显示文摘AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate mediators.METHODS:Patients who underwent coronary angiography were consecutively recruited.The patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel disease.Abdominal ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,severe.We measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein levels.RESULTS:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed NAFLD.Among the 46 patients with CAD,37(80.4%)had evidence of a fatty liver.The two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty liver.Coronary artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent manner.Moreover,adiponectin might be related to the pathogenesis of NAFLD. | Dae Hee Choi Sung Joon Lee Chang Don Kang Myoung Ok Park Dong Wook Choi Tae Suk Kim Wonho Lee Byung Ryul Cho Yong Hoon Kim Bong-ki Lee Dong Ryeol Ryu Ji Won Lee | 2013 | World Journal of Gastroenterology2013，19，38： | 5 |
| 3 | DIRECT NUMERICAL SIMULATIONS OF THE DYNAMICS OF PARTICLES WITH ARBITRARY SHAPES IN SHEAR FLOWS显示文摘A fluid-structure interaction method based on the arbitrary Lagrangian-Eulerian method and a dynamic mesh method was developed to simulate the dynamics of a rigid particle in shear flows.In the method,the governing equations for the fluid flow and particle motion were sequentially solved in a two-way coupling fashion.The mesh system was deformed or re-meshed by the dynamic mesh method.The method was employed to simulate the dynamics of a single particle suspended in a flow channel and the dynamics of the particle were studied.The simulation results show that the angular velocity is not only a function of the inclination angle,is but also influenced by the aspect ratio yielding a hysteresis,while the angular velocity obtained from the Keller-Scalak model is a function only of the inclination angle and does not show a hysteresis.The present simulations clearly demonstrate that the Fluid-Structure Interaction(FSI) module is very stable,accurate and robust. | CHOI Choeng Ryul KIM Chang Nyung | 2010 | Journal of Hydrodynamics2010，22，4： | 4 |
| 4 | Risk assessment for the development of hepatocellular carcinoma: According to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease显示文摘 | Jong Ryul Eun Heon Ju Lee Tae Nyeun Kim Kyeung Soo Lee | 2010 | Journal of Hepatology2010，，1： | 3 |
| 5 | Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years: from the Korean Transradial Intervention Prospective Registry显示文摘为冠的过程的 BackgroundRadial 动脉存取是一种安全、有益的技术。然而,当存取地点的一个更高的风险组与更年轻的病人相比联系了复杂并发症,老病人被考虑了。这研究被进行调查 transradial 的可行性和安全在从在 20 个中心的朝鲜 Transradial 干预未来的登记的 6132 个病人的 elderly.MethodsA 总数的冠的 angiography 或干预被分析。病人们被划分成非老的组(n = 5667 ) 并且老(80 年) 组织(n = 465 ) 。用倾向分数匹配,老组(n = 465 ) 与相比一对一匹配非老的组(n = 465 ).ResultsAfter 倾向 20 匹配的、吝啬的年龄是 64.3 汵琠敲瑡敭瑮漠 ? 湩牴捡牡楤捡愠物攠扭汯獩 ? 獵湩 ? 湩牴捡牡楤捡挠瑡敨整 ? | Hoyoun Won Wang Soo Lee Sang-Wook Kim Byung Ryul Cho Young Jin Youn Young-Hyo Lim Min-Ho Lee Jae-Hwan Lee Seung-Woon Rha | 2017 | Journal of Geriatric Cardiology2017，14，2： | 2 |
| 6 | Risk assessment for the development of hepatocellular carcinoma: According to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease显示文摘 | Jong Ryul Eun Heon Ju Lee Tae Nyeun Kim Kyeung Soo Lee | 2010 | Journal of Hepatology2010，，1： | 1 |
| 7 | Chylothorax Complicating Pulmonary Resection for Lung Cancer: Effective Management and Pleurodesis显示文摘 | Hyun Jin Cho Dong Kwan Kim Geun Dong Lee Hee Je Sim Se Hoon Choi Hyeong Ryul Kim Yong-Hee Kim Seung-Il Park | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 8 | Polyamide thin-film nanofiltration membranes Ti02 nanoparticles 显示文摘 | Lee H S Kim S J Kim J H Min J P Ryul B | 2008 | Desalination2008，219，： | 1 |
| 9 | Coregistration of terrestrial lidar points by adaptive scale-invariant feature transformation with constrained geometry显示文摘 | Yang Dam Eo Mu Wook Pyeon Sun Woong Kim Jang Ryul Kim Dong Yeob Han | 2012 | Automation in Construction2012，，： | 1 |
| 10 | Dynamic characteristic analysis considering core losses in transverse flux linear machine with solid cores显示文摘 | Ji Young Lee Ji Won Kim Seung Ryul Moon | 2009 | IEEE Transactions on Magnetics2009，45，3： | 1 |
| 11 | A new technique for preparation of PDMS pervaporation membrane for VOC removal 显示文摘 | Hee Jin Kim Sung Soon Nah Byoung Ryul Min | 2002 | Adv Environ Res2002，6，3： | 1 |
| 12 | Three - Dimensional Analysis of Migration and Staple Yarn Structure 显示文摘 | Young Ryul Kim Woon Young Ryu | 2000 | Textile ResJ2000，，71： | 1 |
| 13 | A new technique for preparation of PDMS pervaporation membrane for VOC removal显示文摘 | Hee Jin Kim Sung Soon Nah Byoung Ryul Min | 2002 | Advances in Environmental Research2002，6，： | 1 |
| 14 | Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes显示文摘 | Jung Jin Lim Jin Hee Eum Jeoung Eun Lee Eun Sun Kim Hyung Min Chung Tae Ki Yoon Kye-Seong Kim Dong Ryul Lee | 2010 | Journal of Assisted Reproduction and Genetics2010，，11： | 1 |
| 15 | A new technique for preparation ofPDMS perva- poration membrane for VOC removal 显示文摘 | Hee Jin Kim Sung Soon Nah Byoung Ryul Min | 2002 | Advances in Environmental Research2002，，06： | 1 |
| 16 | Dynamic charaeteristie analysis considering core losses in transverse flux lin- ear machine with solid cores 显示文摘 | LEE Ji Young KIM Ji Won MOON Seung Ryul ct al | 2009 | IEEE Transactions on Magnet- ics2009，45，3： | 1 |
| 17 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 18 | Analyzing structural and physical properties of ring,rotor,and friction spun yarns显示文摘 | HUH You KIM Young Ryul OXENHAM William | 2002 | Textile Res J2002，72，2： | 1 |
| 19 | A new Technique for Preparation of PDMS Pervaporation Membrane for VOC Removal显示文摘 | Hee Jin Kim Sung Soon Nah Byoung Ryul Min | | Advances in Environmental Research0，6，： | 1 |
| 20 | Plasmonic Ag‑Decorated Few‑Layer MoS2 Nanosheets Vertically Grown on Graphene for Efficient Photoelectrochemical Water Splitting显示文摘A controllable approach that combines surface plasmon resonance and twodimensional(2D)graphene/MoS2 heterojunction has not been implemented despite its potential for efficient photoelectrochemical(PEC)water splitting.In this study,plasmonic Ag-decorated 2D MoS2 nanosheets were vertically grown on graphene substrates in a practical large-scale manner through metalorganic chemical vapor deposition of MoS2 and thermal evaporation of Ag.The plasmonic Ag-decorated MoS2 nanosheets on graphene yielded up to 10 times higher photo-to-dark current ratio than MoS2 nanosheets on indium tin oxide.The significantly enhanced PEC activity could be attributed to the synergetic effects of SPR and favorable graphene/2D MoS2 heterojunction.Plasmonic Ag nanoparticles not only increased visible-light and near-infrared absorption of 2D MoS2,but also induced highly amplified local electric field intensity in 2D MoS2.In addition,the vertically aligned 2D MoS2 on graphene acted as a desirable heterostructure for efficient separation and transportation of photo-generated carriers.This study provides a promising path for exploiting the full potential of 2D MoS2 for practical large-scale and efficient PEC water-splitting applications. | Dong‑Bum Seo Tran Nam Trung Dong‑Ok Kim Duong Viet Duc Sungmin Hong Youngku Sohn Jong‑Ryul Jeong Eui‑Tae Kim | 2020 | Nano-Micro Letters2020，12，12： | 1 |
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