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| 1 | Induction of fibroblasts to neurons through adenoviral gene delivery显示文摘 | Fengxi Meng Siye Chen Qinglong Miao Kechun Zhou Qicheng Lao Xiaohui Zhang Wenyi Guo Jianwei Jiao | 2012 | Cell Research2012，22，2： | 4 |
| 2 | Expanding metabolism for biosynthesis of nonnatural alcohols显示文摘 | Zhang Kechun Sawaya M R Eisenberg D S | 2008 | Proc Natl Acad Sci USA2008，105，20： | 1 |
| 3 | Inhibition of TRPC6degradation suppresses ischemic brain damage in rats显示文摘 | Wanlu Du Junbo Huang Kechun Zhou et al | 2010 | Journal of Clinical Investigation2010，120，10： | 1 |
| 4 | TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons显示文摘 | Zhuohao He Caixia Jia Shengjie Feng Kechun Zhou Yilin Tai Xue Bai Yizheng Wang | 2012 | Journal of Neuroscience2012，，27： | 1 |
| 5 | Interaction of HIV-1 fusion peptide and its mutant with lipid membrane显示文摘HIVWT and HIVV2E represent the 23 amino acids fusion peptide of HIV-1 gp41 N terminus and its position 2 mutant (Val→Glu). We have studied the structure-function relationship of HIVWT and HIVV2E when they interact with acidic and neutral lipid membranes. The results show that HIVWT and HIVV2E have the same conformational characteristics and tendencies of conformational transition but definitely different functions: HIVWT destabilizes membrane and induces fusion by adopting predominant α-helix conformation when interacting with acidic POPG membrane, its phenylalanine residues can penetrate into the hydrophobic core of POPG bilayer; HIVV2E also adopts predominant α-helix when interacting with POPG membrane, but it cannot destabilize POPG membrane and induce fusion, the phenylalanine residues of it are located near the surface of POPG bilayer. HIVWT and HIVV2E both adopt predominant β-sheet conformation to interact with neutral POPC membrane, and cannot destabilize POPC membrane and induce fusion, | QIU Yang SHA Yinlin HUANG Lixin LIN Kechun NIE Songqing | 2000 | Chinese Science Bulletin2000，45，9： | 1 |
| 6 | Abnormal behavior of fluorescence quenching of gramicidin A inphase transition of lipid vesicles by hypocrellin B——Does anelectron transfer inverted region exist?显示文摘The fluorescence of gramicidin A(GA) in lipid bilayer may be quenched by Hypocre-Ilin B. When the phospholipids undergo a phase transition from gel to liquid crystalline phase, the reaction rate decreases unusually. This phenomenon has been analyzed by Marcus’ pho-toinduced electron theory, and an electron transfer inverted region hypothesis is proposed, | Jiachang Yue Yeping Li Yaxian Su Kechun Lin | 1999 | Chinese Science Bulletin1999，44，21： | 0 |
| 7 | Starting Control of Free Piston Stirling Linear Generator System Based on FOC显示文摘Aiming at the problem of poor system dynamic performance caused by low parameter matching in the coordinated control of Stirling engine and linear generator in the starting stage control of free piston Stirling linear generator system,a joint control method of free piston Stirling permanent magnet synchronous linear generator system based on field orientation control is proposed,based on the theoretical derivation of the mathematical model of the system and the principle of controller parameters setting,the simulation experiments of the system starting stage under several Stirling engine working conditions are carried out under simulation.The experimental results show that the stability and rapidity of the system are improved,and the dynamic response speed of generator parameters under different working conditions is accelerated,what fully verifies the correctness and effectiveness of the method.It provides an effective way to improve the control performance of the system and stabilize the power generation operation. | Qiaoling Yang Kechun Zhang Shenghui Guo Boliang Song Xiaoyu Zhang | 2022 | CES Transactions on Electrical Machines and Systems2022，6，2： | 0 |
| 8 | Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects:A review显示文摘Kunxian Capsule(KX)is a popular Chinese patent medicine for the treatment of rheumatoid arthritis,nephrotic syndrome,systemic lupus erythematosus,Henoch-Schönlein purpura,ankylosing spondylitis,psoriatic arthritis and eczema.However,there is scarcity of comprehensive information on the significance of KX in the clinical application and its side effects.Hence,it is aimed to provide a review of the significance of KX,with a focus on the pharmacological effects,clinical applications,and its adverse reactions.This review was based on the published literatures in PubMed,China National Knowledge Infrastructure and WanFang database.The articles were collected by two independent authors with no time limits applied until November 30,2022.The search term includes Kunxian Capsule and/or clinical effect,pharmacology,disease,therapy,adverse effects and quality control.KX has been shown to be effective in the treatment of autoimmune arthritis by inhibiting inflammatory responses and inducing apoptosis.Many studies suggest that KX has anti-inflammatory and analgesic properties that aid in the improvement of joint functions.KX dispels wind,removes dampness,invigorates the kidneys,and promotes blood circulation,thereby curing various diseases.However,studies also suggest KX-related adverse reactions in multiple systems.Overall,this review highlights the scientific basis of KX in curing or preventing various diseases and provides novel insights for further research and clinical applications. | Ruijiao Ma Maharajan Kannan Kaiyan Zhuang Qing Xia Dong Sun Pengfei Tu Taiping Fan Kechun Liu Yun Zhang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 9 | Plasma exchange therapy for acute necrotizing encephalopathy of childhood显示文摘Importance Acute necrotizing encephalopathy(ANE)is a rare disease with high mortality.Plasma exchange(PLEX)has recently been reported to treat ANE of childhood(ANEC),but its efficacy is uncertain.Objective This study aimed to investigate the effectiveness of PLEX on ANEC.Methods A retrospective study was conducted in four pediatric intensive care units from December 2014 to December 2020.All patients who were diagnosed with ANEC were included;however,these patients were excluded if their length of stay was less than 24 h.Participants were classified into PLEX and non-PLEX groups.Results Twenty-nine patients with ANEC were identified,10 in the PLEX group and 19 in the non-PLEX group.In the PLEX group,C-reactive protein,procalcitonin,alanine aminotransferase,and aspartate aminotransaminase levels were significantly lower after 3 days of treatment than before treatment(13.1 vs.8.0,P=0.043;9.8 vs.1.5,P=0.028;133.4 vs.31.9,P=0.028;282.4 vs.50.5,P=0.046,respectively).Nine patients(31.0%,9/29)died at discharge,and a significantly difference was found between the PLEX group and non-PLEX group[0 vs.47.4%(9/19),P=0.011].The median follow-up period was 27 months,and three patients were lost to follow-up.Thirteen patients(50.0%,13/26)died at the last follow-up,comprising three(33.3%,3/9)in the PLEX group and ten(58.8%,10/17)in the non-PLEX group,but there was no significant difference between the two groups(P=0.411).Three patients(10.3%,3/29)fully recovered.Interpretation PLEX may reduce serum C-reactive protein and procalcitonin levels and improve liver function in the short term.PLEX may improve the prognosis of ANEC,and further studies are needed. | Kechun Li Tao Zhang Gang Liu Ping Jin Yeqing Wang Lijie Wang Meixian Xu Chunyi Liu Yingchao Liu Tao Zhou Yan Xu Ying Yang Boliang Fang Xin Yang Chunfeng Liu Suyun Qian | 2021 | Pediatric Investigation2021，5，2： | 0 |
| 10 | Evaluating the Effects of Aquaculture Wastewater Irrigation with Fertilizer Reduction on Greenhouse Tomato Production,Economic Benefits and Soil Nitrogen Characteristics显示文摘The utilization of aquaculture wastewater as irrigation is an effective way to recycle and reuse water and nitrogen fertilizer resources because it contains numerous nutrients.However,it is still unclear that the pattern of substituting aquaculture wastewater irrigation for fertilizer supplementing is conducive to improving the soil nitrogen status,fruit yield and water-fertilizer use efficiency for tomato production.In this context,the experiment was intended to establish the appropriate irrigation regime of aquaculture wastewater in tomato production for freshwater replacement and fertilizer reduction to ensure good yields.Pot experiments were conducted with treatments as farmers accustomed to irrigation and fertilization used as control(CK),1.75 L aquaculture wastewater with base fertilizer(W1),2 L aquaculture wastewater with base fertilizer;and 2.25 L aquaculture wastewater with base fertilizer(W3).We examined the effects of aquaculture wastewater irrigation on soil nitrogen distribution,Nrelated hydrolases,tomato yield,and economic benefits.The results showed that the control treatment had the highest N input,about 24.68%higher than the W3 treatment,while the yield was only about 7.81%higher than W3.This indicated that the overuse of chemical fertilizer was present in the current tomato production.Although the reduction of fertilizer in aquaculture wastewater irrigation caused a decrease in tomato production,this economic loss can be compensated by cost savings in the wastewater disposal.Among aquaculture wastewater treatments,the W3 treatment had the highest overall benefit,achieving 62.63%freshwater savings,37.50%fertilizer input reduction,and an economic return of approximately 19,466 Yuan per hectare higher than the control.Additionally,increasing the irrigation volume of aquaculture wastewater could provide more available nutrients to the soil,which were more prevalent in the form of organic nitrogen.The lower soil nitrate reductase activities(NR)under aquaculture wastewater treatments after harvesting also proved that this pattern was beneficial to reduce soil nitrate nitrogen residues.Overall,the results demonstrate that aquaculture wastewater irrigation alleviates the soil nitrate residues,improves nutrient availability,and results in more economic returns with water and fertilizer conservation for the greenhouse production of tomatoes. | Hang Guo Linxian Liao Zhenhao Zheng Junzeng Xu Qi Wei Peng Chen Kechun Wang | 2023 | Phyton-International Journal of Experimental Botany2023，92，12： | 0 |
| 11 | Effect of Ab_(1-40) on membrane permeability and intracellular free Ca^(2+) of nerve cells显示文摘The effects of soluble and fibrillar Ab1-40 on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Ab1-40 on cell membrane permeability are both concentration-de- pendent. Soluble Ab1-40 increases membrane permeability only at concentration of 3 mmol/L, while the toxic effect of fibrillar Ab1-40 is much stronger, its evident effect begins from 1 mmol/L. When its concentration rose to 3 mmol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Ab1-40 at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Ab1-40 and the change of physico-chemical properties and intracellular Ca ion imbalance. | MA Xiaocui, SHA Yinlin, LIN Kechun & NIE Songqing Department of Biophysics, Peking University Health Science Center, Beijing 100083, China | 2003 | Chinese Science Bulletin2003，48，10： | 0 |
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