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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 4 | Human Neuroblastonm( SH- SY5Y) Cell Culture and Differentiation in 3-D Collagen Hydrogels for Cell-Based Biosensing 显示文摘 | Desai A Kisaalita W S Keith C | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
| 5 | Effects of simulated acidic rain on yields of field-grown crops显示文摘 | LNACE S E KEITH F L ELIZABETH A C | 1982 | New Phytol1982，91，： | 1 |
| 6 | Control of p70 S6 kinase by kinase activity of FRAP in vivo显示文摘 | Brown E J Beal P A Keith C T | 1995 | Nature1995，377，6548： | 1 |
| 7 | Mining changes in association rules:a fuzzy approach显示文摘 | Wai-Ho A Keith C C Chan | 2005 | Fuzzy Sets and Systems2005，149，： | 1 |
| 8 | An improved simple morphological filter for the terrain classification of airborne LiDAR data 显示文摘 | Thomas J Pingel Keith C Clarke William A McBride | 2013 | ISPRS Journal of Photogrammetry and Remote Sensing2013，77，： | 1 |
| 9 | Effects of simulated acidic rain on yields of field- grown crops 显示文摘 | Lance S E Keith F L Elizabeth A C | 1982 | New Phytologist1982，91，： | 1 |
| 10 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
| 11 | The impact of urban development on hydrologic regime from catchment to basin scales 显示文摘 | Yang G Laura C B Keith A C | 2011 | Landsc Urban Plan2011，103，： | 1 |
| 12 | The effects of vasopressin on acute kidney injury in septic shock显示文摘 | ANTHONY C GORDON JAMES A RUSSELL KEITH R WAL- LEY | 2010 | Intensive Care Med2010，36，： | 1 |
| 13 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 14 | Multicomponent therapeutics for networked systems 显示文摘 | Keith C T Borisy A A Stockwell B R | 2005 | Nat Rev Drug Discov2005，4，1： | 1 |
| 15 | Uptake and distribution of iron and transferrin in the adult rat brain显示文摘 | Morris C M Keith A B Edwardson J A | 1992 | J Neurochem1992，59，1： | 1 |
| 16 | Waterjet-hull Interaction: recent experimental results显示文摘 | KEITH A HAMISH C VAN T | 1994 | SNAME Transactions1994，102，： | 1 |
| 17 | Synthetic antican cer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors显示文摘 | Dufes C Keith WN Bilsland A | 2005 | Cancer Res2005，65，18： | 1 |
| 18 | A new z-source DC circuit breaker显示文摘 | Keith A C Robert W A | 2002 | IEEE Transactions on Power Electronic2002，27，6： | 1 |
| 19 | Hatch dates and growth of Ommastrephes bartramii paralarvae from hawaiian waters as determined from statolith analysis 显示文摘 | KEITH A BIGELOW KEVIN C | 1993 | Recent Advances in fisheries Biology1993，，： | 1 |
| 20 | Effect of alternative types of influence strategies under different channel depen-dence structures 显示文摘 | Keith J E Donald W J and Lawrence A C | 1990 | Journal of Marketing1990，54，7： | 1 |
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