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| 1 | Predicting intrinsic disorder in proteins: an overview显示文摘 | Bo He Kejun Wang Yunlong Liu Bin Xue Vladimir N Uversky A Keith Dunker | 2009 | Cell Research2009，19，8： | 11 |
| 2 | Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice显示文摘The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity (DIO) model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations (JH17 & JH18) of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the 6 week study. Body weights were measured two times a week and food intake was measured weekly. At week 6, mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 (IGF-1) were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JH17 & JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses (> 1:500,000 titer). IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates (mean 440.4 ng/mL) when compared with PBS controls (mean 365.6 ng/mL). Vaccination with either JH17 or JH18 chimeric-somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls (P < 0.0001), even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin antibodies at 6 weeks was correlative with the weight observations and confirmed the success of vaccination. | Keith N Haffer | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 3 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 4 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 5 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 6 | Targeting telomerase for cancer therapeutics显示文摘 | Shay J W Keith W N | 2008 | Br J Cancer2008，98，4： | 1 |
| 7 | The Drosophila membrane receptor Toll promote cellular adhesion function to显示文摘 | Keith F J Gay N J | | 0，，： | 1 |
| 8 | Carbon and oxygen isotopic composi tion of selected limestones and fossils显示文摘 | Keith M L Weber J N | 1964 | Geochimica et Cos- mochimica Acta1964，28，10： | 1 |
| 9 | Nodal detection in malignant melanoma of the vigina using laparoscopic ultrasonography显示文摘 | Shing - shun N siu Keith K Lo | 2004 | Gynecol Oncol2004，92，3： | 1 |
| 10 | Carbon and oxygen isotopic composition of selected limestone and fossils 显示文摘 | KEITH M L WEBER J N | 1964 | Geochim et Cosmochim Acta1964，28，10： | 1 |
| 11 | Precipitation evolution in Al-Zr and Al-Zr-Ti alloys during aging at 450-600 ℃显示文摘 | Knipling Keith E Dunand David C Seidman David N | 2008 | Acta Materialia2008，56，： | 1 |
| 12 | Carbon and oxygen isotopic composition of mollusk shells from marine and fresh water environment显示文摘 | Keith W L Weber J N | | 0，，10： | 1 |
| 13 | Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’显示文摘 | Konstantinos N Lazaridis Gregory J Gores Keith D Lindor | 2001 | Journal of Hepatology2001，，1： | 1 |
| 14 | Evidence for a Second Crystal Form of Polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 15 | Isotopic composition and environmental classification of selected limestones and fossils显示文摘 | Keith M L Weber J N | 1964 | Geochimica et Cosmochimica Acta1964，28，： | 1 |
| 16 | Rehabilitation after total shoulder arthroplasty显示文摘 | Douglas N Robert H Keith A | 2001 | J Arthroplasty2001，16，4： | 1 |
| 17 | Precipitation evolution in Al-Zr and Al-Zr-Ti alloys during isothermal aging at 375-425 ℃显示文摘 | Knipling Keith E Dunand David C Seidman David N | 2008 | Acta Materialia2008，56，： | 1 |
| 18 | Carbon and Oxygen Isotopic Composition of Selected Limestones and Fossils显示文摘 | Keith M I Weber J N | 1964 | Geochimica et Cosmochimica Acta1964，28，： | 1 |
| 19 | Carbon and oxygen isotopic composition of selected limestones and fossils显示文摘 | Keith M L Weber J N | 1964 | Geochimica et Cosmochimica Acta1964，28，1011： | 1 |
| 20 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
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