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| 1 | Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis显示文摘AIM: To assess the safety of bismuth used in Helico- bacter pylori (H pylori) eradication therapy regimens. METHODS: We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppres- sion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals (CI). RESULTS: We identified 35 randomised controlled tri- als containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth [relative risk (RR) = 1.01; 95% CI: 0.87-1.16], specific individual adverse events, with the exception of dark stools (RR = 5.06; 95% CI: 1.59-16.12), or adverse events leading to withdrawal of therapy (RR = 0.86; 95% CI: 0.54-1.37). CONCLUSION: Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event oc- curring significantly more commonly was dark stools. | Alexander C Ford Peter Malfertheiner Monique Giguère José Santana Mostafizur Khan Paul Moayyedi | 2008 | World Journal of Gastroenterology2008,14,48: | 62 |
| 2 | 精确农业田间土壤空间变异与采样方式研究显示文摘以英国 Hillsborough农业研究所附近的一块 7.9hm2的牧草地为研究区 ,采用地统计的半方差分析和克立格方法研究其空间变异性和空间插值。同时对研究田块的样点根据不同间距、不同形状进行删选 ,对不同布局状况下的结果进行统计比较 ,以获取满足一定精度下的最少采样个数和采样形状。研究结果表明 ,单纯利用样方统计 ,土壤有效钾需要 6 5个采样点 ,大致为原始采样点的一半。而在考虑空间采样形状和空间插值效果 ,再采用最小显著性差异 (L SD)进行比较 ,该田块土壤有效钾采样最好使用规则三角网布点 (样点数为 6 2个 )。 | 王珂 沈掌泉 John S.Bailey Craw ford Jordan | 2001 | 农业工程学报2001,17,2: | 65 |
| 3 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018,26,4: | 58 |
| 4 | 国外栽培豌豆遗传多样性分析及核心种质构建显示文摘从111对备选SSR引物中筛选出能扩增出清晰稳定单一带的多态性引物21对及其最佳退火温度,并优化了豌豆SSR标记实验体系。利用上述引物,对来自于67个国家的731份豌豆栽培种质(Pisum sativum L.)进行遗传多样性分析与核心种质构建。共扩增出109条多态性带,每对引物平均扩增出5.19个等位变异。SSR等位变异在各大洲间分布不均匀,有效等位变异数、Shannon's信息指数(I)洲际间差异明显。各大洲资源群间遗传多样性差异显著,其中亚洲最高(I=1.1753),欧洲其次(I=1.1387),俄罗斯联邦(I=1.0285)、美洲(I=1.0196)、非洲(I=0.9254)、大洋洲(I=0.8608)依次降低。利用Popgene1.32软件,依豌豆栽培资源洲际间Nei78遗传距离可聚类成2个组群和4个亚组群;基于Structure 2.2软件分析,国外栽培豌豆资源实际由3大类群组成,并与Popgene 1.32聚类结果呼应得较好。上述两种分析方法均表明,国外栽培豌豆类群的遗传多样性与其地理分布相关。设计并实践了一套基于Structure分析的科学可靠、逻辑性强的核心种质构建标准化方案,并依此构建了一套以6.57%的资源(48份)涵盖总体84.4%等位变异的国外栽培豌豆核心种质。 | 宗绪晓 关建平 王述民 刘庆昌 Robert R Redden Rebecca Ford | 2008 | 作物学报2008,34,9: | 31 |
| 5 | Non-viral causes of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers worldwide.The main etiology of HCC is chronic infection with hepatitis B and hepatitis C viruses.However,there are other important factors that contribute to the international burden of HCC.Among these are obesity,diabetes,non-alcoholic steatohepatitis and dietary exposures.Emerging evidence suggests that the etiology of many cases of HCC is in fact multifactorial,encompassing infectious etiologies,comorbid conditions and environmental exposures.Clarification of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease. | Wojciech Blonski David S Kotlyar Kimberly A Forde | 2010 | World Journal of Gastroenterology2010,16,29: | 25 |
| 6 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)显示文摘 | E.A. Eisenhauer P. Therasse J. Bogaerts L.H. Schwartz D. Sargent R. Ford J. Dancey S. Arbuck S. Gwyther M. Mooney L. Rubinstein L. Shankar L. Dodd R. Kaplan D. Lacombe J. Verweij | 2008 | European Journal of Cancer2008,,2: | 22 |
| 7 | 豌豆属(Pisum)SSR标记遗传多样性结构鉴别与分析显示文摘【目的】评价豌豆属(Pisum L.)2个种5个亚种下,共8个资源类群的遗传多样性水平,揭示豌豆属下资源群体结构及其遗传关系远近,验证传统植物学分类的可靠程度,为充分发掘、利用豌豆野生种质提供必要信息。【方法】利用21对豌豆多态性SSR引物,对来自世界5大洲62个国家的豌豆属94份栽培种质(P.sativum ssp.sativum var.sativum)及其1个近缘野生种(P.fulvum),3个野生亚种(P.sativum ssp.abyssinicum、P.sativum ssp.asiaticum、P.sativum ssp.transcaucasicum)和3个野生变种(P.sativum ssp.elatius var.elatius、P.sativum ssp.elatius var.pumilio、P.sativum ssp.sativumvar.arvense)的103份野生种质进行SSR标记遗传多样性分析;利用NTSYSpc2.2d软件估算其遗传距离,进行主成分分析(PCA)并绘制三维空间聚类图;利用Popgene V1.32估算种质群间的Nei78遗传距离等参数并进行UPGMA聚类分析,采用MEGA3.1绘制种质群间聚类图;采用Popgene V1.32估算种质群的等位位点分布等参数,利用Fstat V2.9.3.2进行种质群间遗传多样性差异显著性测验。【结果】21对豌豆多态性SSR引物共扩增出104条多态性带,每对引物平均扩增出4.95个等位变异,其中有效等位变异占65.56%;PSAD270,PSAC58,PSAA18,PSAC75,PSAA175和PSAB72等SSR引物最为有效。SSR等位变异在豌豆属植物学分类单位中分布均匀,但分类单位种质群间的遗传多样性在多数情况下差异显著。豌豆属野生种P.fulvum的遗传多样性远低于栽培种P.sativum;豌豆栽培种下,P.sativum ssp.sativum var.sativum和P.sativum ssp.asiaticum的遗传多样性最高,P.sativum ssp.elatius var.elatius和P.sativum ssp.transcaucasicum次之,P.sativum ssp.elatius var.pumilio、P.sativum ssp.sativum var.arvense和P.sativumssp.abyssinicum最低。PCA分析发现,豌豆属种质资源由4个差异明显的基因库构成。'fulvum'基因库主要由野生种Pisum fulvum资源构成,'abyssinicum'基因库主要由栽培种下的P.sativum ssp.abyssinicum亚种资源构成,'arvense'基因库主要由栽培种下的P.sativum ssp.sativumvar.arvense变种资源构成;'sativum'基因库由P.sativum ssp.asiaticum、P.sativum ssp.elatius var.elatius、P.sativum ssp.transcaucasicum、P.sativum ssp.elatius var.pumilio和P.sativum ssp.sativum var.sativum资源构成。'sativum'基因库构成豌豆栽培资源初级基因库;'fulvum'、'abyssinicum'和'arvense'基因库共同构成豌豆栽培资源次级基因库。植物学分类单位间的Nei78遗传距离介于7.531~35.956,UPGMA聚类方法将豌豆属植物学分类单位聚成3个组群,'组群I'对应'sativum'和'arvense'基因库之和,'组群II'对应'abyssinicum'基因库,'组群III'对应'fulvum'基因库,聚类结果支持4个基因库的划分。【结论】豌豆属下多数植物学分类单位间遗传多样性差异显著,并分化成4个基因库。研究结果部分支持豌豆属下传统的植物学分类体系,并指出了其合理与不足之处。为拓宽豌豆育成品种的遗传基础,应充分发掘豌豆属下各基因库的遗传潜力。 | 宗绪晓 Rebecca Ford Robert R Redden 关建平 王述民 | 2009 | 中国农业科学2009,42,1: | 18 |
| 8 | Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis显示文摘 | Rebecca M. Lovell Alexander C. Ford | 2012 | Clinical Gastroenterology and Hepatology2012,,7: | 13 |
| 9 | 表面致密化——一种提高烧结齿轮性能的有效方法显示文摘表面致密化与传统的粉末冶金方法相结合 ,可以显著改善烧结齿轮的疲劳及表面磨损性能 ,从而提高齿轮的寿命 ,同时使生产高性能齿轮的总成本降低 ,为用粉末冶金 (PM)方法生产汽车变速箱齿轮提供了更大的可能性。本文着重讲述了使用这种方法生产高性能PM齿轮的工艺过程 ,同时介绍了测定致密化效果及齿轮性能的几种主要方法 ,并根据工艺过程比较了使用传统的机加工方法及本文所述的方法生产同性能齿轮的成本差别。最后 ,以两个实例分别介绍了使用上述方法对Volvo 85 0系第五挡变速齿轮及Scania载重车变速箱中行星齿轮的研发。 | 于洋 Linnea Fordén | 2005 | 粉末冶金技术2005,23,1: | 11 |
| 10 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013,19,34: | 9 |
| 11 | Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis显示文摘BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes.AIM To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMR) of colorectal lesions ≥ 20 mm.METHODS We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects model.RESULTS Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P < 0.001) following EMR of lesions ≥ 20 mm.There was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMR of large colorectal lesions.Future trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy. | Fares Ayoub Donevan R Westerveld Justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang | 2019 | World Journal of Gastroenterology2019,25,18: | 9 |
| 12 | 儿童青少年体力活动与骨健康研究的10大问题显示文摘证据强烈支持体力活动对骨强度有积极的因果效应,并指出儿童进行体力活动对预防骨质疏松有长远益处。年轻时的健康骨骼可能对预防成年后由于骨量丢失而发生骨质疏松有重要作用。家庭、学校(特别是体育课)和社区是进行骨骼健康促进体力活动的重要场所。然而,有关健康促进和体育课对骨骼健康的话题很少,因此最佳的实践方法还不清楚。基于文献资料的了解,我们提出了应该被解决的健康促进和体育课研究的10大问题,从而促进儿童青少年的体力活动。 | Kathleen F.Janz David Q.Thomas M.Allison Ford Skip M.Williams | 2016 | 北京体育大学学报2016,39,1: | 8 |
| 13 | 溃疡性结肠炎显示文摘溃疡性结肠炎(ulcerativecolitis,uc)是一种消化道炎症性疾病,病变主要位于结直肠。UC好发于青年人,发达国家的人群患病率较高。UC表现为结直肠弥漫性、连续性浅表炎症,以及相应的组织学改变。下消化道内镜或影像检查可以明确诊断。目前尚未发现UC的明确病因,其发病机制与遗传易感个体的结肠内环境变化有关,具有慢性、终身、易复发的病程特点。 | Alexander C Ford Paul Moayyedl Steven B Hanauer Joseph B Kirsner 谭蓓 吴东 | 2017 | 英国医学杂志中文版2017,20,7: | 7 |
| 14 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)显示文摘 | E.A. Eisenhauer P. Therasse J. Bogaerts L.H. Schwartz D. Sargent R. Ford J. Dancey S. Arbuck S. Gwyther M. Mooney L. Rubinstein L. Shankar L. Dodd R. Kaplan D. Lacombe J. Verweij | 2008 | European Journal of Cancer2008,,2: | 6 |
| 15 | 氮肥:迎接当代挑战显示文摘商业氮肥以8170万t之巨,约占现今所有抵达地球耕地氮肥的50%,至少给40%的人口提供了基本的食物需求。摆在我们面前的挑战是,继续帮助满足那种需求,而又要通过改善氮肥利用效率把对环境的负面影响减到最小。在美国,玉米上的氮肥效率在近20年里提高了30%以上,但在玉米和其它作物上尚有潜力可挖。在大多数亚洲国家目前的氮肥效率和生产率比北美一般要低,但他们正在做出努力加以改进。化肥工业认识到在满足人类现今和将来的基本需求方面它所担负的关键角色。它已准备好迎接新的挑战,采用新的实践和技术来提高效率,并以此不仅支持人类生命而且改善人们生活的质量。 | Paul E.Fixen Ford B.West 李康民 | 2002 | AMBIO-人类环境杂志2002,31,2: | 5 |
| 16 | 心率作为冠心病与左室收缩障碍患者的预后危险因素(BEAUTIFUL):一项随机、对照试验的一个亚组分析显示文摘背景BEAUTIFUL研究对降心率药物伊伐布雷定的发病率与病死率收益进行了评估。BEAUTIFUL试验中的安慰剂组是由稳定型冠心病与左室收缩功能障碍的大型患者队列组成。我们对该安慰剂组进行了亚组分析,旨在检验这样一种假设,即基线静息心率升高是心血管疾病发病与死亡的标志。
方法采用Cox比例风险模型,对心率≥70次/min患者(2693例)以及〈70次/min患者(2745例)进行对比,分析基线静息心率与心血管结局之间的关系。将心率作为一个连续变量,并采用更为精细的心率分类进行其他分析。
结果在对基线特征进行校正后,心率≥70次/min患者的心血管疾病死亡(34%,P=0.0041)、心力衰竭入院(53%,P=0.0001)、心肌梗死入院(46%,P=0.0066)及冠状动脉血运重建(38%,P=0.037)风险升高。心率每升高5次/min,患者的心血管疾病死亡(8%,P=0.0005)、心力衰竭入院(16%.P〈0.0001)、心肌梗死入院(7%,P=0.052)及冠状动脉血运重建(8%,P=0.034)风险亦升高。对心率精细分组的分析表明,心率〉70次/min患者的病死率与心力衰竭发生率持续升高,但这种相关性在冠状动脉结局方面并不显著。对于心力衰竭结局而言,静息心率对早期事件的预测价值较晚期事件的预测价值更强。
结论在冠心病和左室收缩功能障碍的患者中,心率升高(≥70次/min)意味着心血管疾病结局风险升高,同时对心力衰竭相关性结局与冠状动脉事件相关性结局有着不同的影响。 | Kim Fox Ian Ford P Gabriel Steg Michal Tendera Michele Robertson Roberto Ferrari 罗亮(译) | 2008 | 世界临床医学2008,2,6: | 5 |
| 17 | Executive Summary: Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010,,7: | 5 |
| 18 | 原发性低密度脂蛋白胆固醇≥4.94mmol/L的男性降低低密度脂蛋白胆固醇对心血管病的影响显示文摘原发性低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)≥4.94mmol/L(190mg/dL)的患者由于长期暴露在显著升高的LDL-C下,心血管动脉粥样硬化的风险更高。因此,对于这些患者通常建议采用他汀类药物治疗,但是缺少随机试验证据支持。在该研究中,研究者提供了一些降低LDL-C对心血管病影响的初级预防资料。 | Vallejo-Vaz AJ Robertson M Catapano AL Watts GF Kastelein JJ Packard CJ Ford I Ray KK 黄洁 叶鹏 | 2017 | 中华高血压杂志2017,25,10: | 5 |
| 19 | 关于发行《世界卫生组织人类精液分析实验室技术手册》(第5版)的评论显示文摘祝贺各位编撰新版《世界卫生组织人类精液分析实验室技术手册》(简称手册)的作者。手册是推广男科学临床实践的重要工具。然而,手册中叙述的检测方法对预测男性生育力的作用有限,且无法揭示生育力低下的潜在原因。呼吁再次关注男性生育力诊断研究。生育能力应该视为一种连续性状,应放弃人为地将其分为有或没有生育力的做法。应以前瞻性研究数据为基础,开发出可预测生育力低下夫妇一年内妊娠可能性的流程,以指导今后复杂的治疗方案的制定。未来将期待建立检测不育潜在病理机制的方法,以开发个性化治疗手段。诸如氧化应激作用、细胞内调节功能缺陷及正在发展的蛋白质组学等前沿领域,均应进行相应的探索。 | Ford WCL 季灵艳 张爱军 范立青 | 2010 | 国际生殖健康/计划生育杂志2010,29,3: | 5 |
| 20 | Reverse-Time Migration from Rugged Topography to Image Ground-Penetrating Radar Data in Complex Environments显示文摘探地雷达偏移成像中,基于高程静校正的基准面偏移方法对起伏地表下的复杂地层成像效果较差。为了优化成像效果,本文提出了一种基于麦克斯韦方程组二阶解耦形式的逆时偏移成像(reversetime migration,RTM)算法,该算法特点在于只需计算电场,且可直接从采集面而非基准面进行波场延拓,进而实现地形逆时偏移。数值模拟比较了高程静校正偏移方法和RTM方法在地表起伏及速度横向变化情况下的成像效果,结果证明RTM方法成像效果更好。为了进一步验证算法效果,利用美国犹他州珊瑚粉沙丘崎岖地形下的实测数据对两种方法进行了对比分析。研究表明,逆时偏移成像方法能够极大地提高复杂环境下探地雷达深度成像精度。 | John H. Bradford Janna Privette David Wilkins Richard Ford | 2018 | Engineering2018,4,5: | 5 |