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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | The Drosophila membrane receptor Toll promote cellular adhesion function to显示文摘 | Keith F J Gay N J | | 0，，： | 1 |
| 3 | Evidence for a Second Crystal Form of Polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 4 | Evidence for a second crystal form of polypropylene显示文摘 | Keith H D Padden F J Jr Walter N M | 1959 | Appl Phys1959，30，： | 1 |
| 5 | A stability analysis for a hydrodynamic three-wave journal bearing显示文摘 | Ene N M Dimofte F Keith J T G | 2008 | Tribology International2008，41，5： | 1 |
| 6 | Evi- dence for a second crystal form of polypropylene 显示文摘 | Keith H D Padden F J Jr Walter N M | 1959 | Applied Physics1959，30，12： | 1 |
| 7 | Evidence for a second crystal form of polypropylene显示文摘 | KEITH H D PADDEN F J WALTER N M | 1959 | J Appl Phys1959，30，12： | 1 |
| 8 | Evidence for a second crystal form of polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 9 | A stability analysis for a hydrodynamic three-wave journal bearing 显示文摘 | Ene N M Dimofte F Keith Jr T G | 2008 | Tribology International2008，41，： | 1 |
| 10 | Androgen regulation of axon growth and neurite extension in motoneurons 显示文摘 | Keith N F Mariarita G Eileen M F | 2008 | Hormones and Behavior2008，53，2： | 1 |
| 11 | A dynamic analysis of hy- drodynamic wave journal bearings 显示文摘 | ENE N M DIMOFFE F KEITH T G | 2008 | Tribology Transactions2008，51，1： | 1 |
| 12 | Drosophila Toll and IL-1 receptor 显示文摘 | GAY N J KEITH F J | 1991 | Nature1991，351，6325： | 1 |
| 13 | Drosophila Toll and IL-1 receptor 显示文摘 | Gay N J Keith F J | 1991 | Nature1991，351，6325： | 1 |
| 14 | The eotaxin chemokines and CCR3 are fundamental, regulators of allergen induced pulmonary eosinophilial显示文摘 | Samuel M Zimmermann N Keith F | 2005 | Immunol2005，175，： | 1 |
| 15 | Practical considerations in kinetic resolution reactions 显示文摘 | KEITH J M LARROW J F JACOBSEN E N | 2001 | AdvSynth Catal2001，343，1： | 1 |
| 16 | A stability analysis for a hy- drodynamic three-wave journal bearing 显示文摘 | Ene N M Dimofte F Keith J T G | 2008 | Tribology Interna- tional2008，41，5： | 1 |
| 17 | Chronicmild stress and sucrose consumption:validity as a model of depression 显示文摘 | Forbes N F Caroline A Keith Matthews | 1996 | Physiol Behav1996，60，6： | 1 |
| 18 | A stability analysis for a hydrodynamic three-wave journal bearing 显示文摘 | Ene N M Dimofte F Keith Jr T G | 2008 | Tribology International2008，41，： | 1 |
| 19 | Durability of steel reinforced concrete in chloride environments : an overview 显示文摘 | Shi X M Xie N Keith F | 2012 | Construction and Building Materials2012，30，5： | 1 |
| 20 | Drosophila toll and IL-1 receptor 显示文摘 | Gay N J Keith F J | 1991 | Nature1991，351，6325： | 1 |
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