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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Implementation of a spatial decision support system for rural land use planning: integrating geographic information system and environmental models with search and optimisation algorithms显示文摘 | Keith B Matthews Alan R Sibbald Susan Craw | 1999 | Computers and Electronics in Agriculture1999，，1： | 2 |
| 3 | Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy显示文摘 | Sean D. Candrilli Keith L. Davis Hong J. Kan Melanie A. Lucero Matthew D. Rousculp | 2007 | Journal of Diabetes and Its Complications2007，，5： | 2 |
| 4 | Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer显示文摘 | Jeffrey A. Meyerhardt Andrew X. Zhu Keith Stuart David P. Ryan Lawrence Blaszkowsky Nicole Lehman Craig C. Earle Matthew H. Kulke Pankaj Bhargava Charles S. Fuchs | 2008 | Digestive Diseases and Sciences2008，，2： | 2 |
| 5 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting显示文摘 | Tong J. Gan Pierre Diemunsch Ashraf S. Habib Anthony Kovac Peter Kranke Tricia A. Meyer Mehernoor Watcha Frances Chung Shane Angus Christian C. Apfel Sergio D. Bergese Keith A. Candiotti Matthew TV Chan Peter J. Davis Vallire D. Hooper Sandhya Lagoo-Deena | 2014 | Anesthesia & Analgesia2014，，： | 2 |
| 6 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 7 | Commercialization of a tomato with an antisense polygalacturonase gene: The FLAVR SAVR? tomato story显示文摘 | Matthew G. Kramer Keith Redenbaugh | 1994 | Euphytica1994，，3： | 1 |
| 8 | Estimating the environmental costs of soil erosion at multiple scales in Kenya using emergy synthesis 显示文摘 | Matthew J Cohen Mark T Brown Keith D Shepherd | 2006 | Agriculture Ecosystems and Environment2006，114，2： | 1 |
| 9 | Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy显示文摘 | Sean D. Candrilli Keith L. Davis Hong J. Kan Melanie A. Lucero Matthew D. Rousculp | 2007 | Journal of Diabetes and Its Complications2007，，5： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | Lymphoepithelial cysts of the pancreas:a management dilemma显示文摘Pancreatic lymphoepithelial cysts(LECs) are rare,benign lesions that are typically unexpected post-operative pathological findings. We aimed to review clinical, radiological and pathological features of LECs that may allow their preoperative diagnosis. Histopathology databases of two large pancreatic units were searched to identify LECs and notes reviewed to determine patient demographic details, mode of presentation, investigations, treatment and outcome. Five male and one female patients were identified. Their median age was 60 years. Lesions were identified on computed tomography performed for abdominal pain in two patients, and were incidentally observed in four patients. Five LECs were located in the tail and one in the body of the pancreas, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a largely acellular aspirate was yielded. The pre-operative diagnosis was mucinous cystic neoplasm in all patients. This series of patients were treated distal pancreatectomy and splenectomy. A retrospective review of radiological examinations suggested that LECs have a relatively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear more common in elderly males, and are typically incidental, large, unilocular cysts. Close attention to signal intensity on MRI may allow preoperative diagnosis of these lesions. | Julie Martin Keith J Roberts Maria Sheridan Gavin A Falk Daniel Joyce R Matthew Walsh Andrew M Smith Gareth Morris-Stiff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 1 |
| 12 | Role of serial multiparametric magnetic resonance imaging in prostate cancer active surveillance显示文摘AIM:To examine whether addition of 3T multiparametric magnetic resonance imaging(mp MRI)to an active surveillance protocol could detect aggressive or progressive prostate cancer.METHODS:Twenty-three patients with low risk disease were enrolled on this active surveillance study,all of which had Gleason score 6 or less disease.All patients had clinical assessments,including digital rectal examination and prostate specific antigen(PSA)testing,every 6 mo with annual 3T mp MRI scans with gadolinium contrast and minimum sextant prostate biopsies.The MRI images were anonymized of patient identifiers and clinical information and each scan underwentradiological review without the other results known.Descriptive statistics for demographics and follow-up as well as the sensitivity and specificity of mp MRI to identify prostate cancer and progressive disease were calculated.RESULTS:During follow-up(median 24.8 mo)11 of 23 patients with low-risk prostate cancer had disease progression and were taken off study to receive definitive treatment.Disease progression was identified through upstaging of Gleason score on subsequent biopsies for all 11 patients with only 2 patients also having a PSA doubling time of less than 2 years.All 23 patients had biopsy confirmed prostate cancer but only 10 had a positive index of suspicion on mp MRI scans at baseline(43.5% sensitivity).Aggressive disease prediction from baseline mpM RI scans had satisfactory specificity(81.8%)but low sensitivity(58.3%).Twentytwo patients had serial mp MRI scans and evidence of disease progression was seen for 3 patients all of whom had upstaging of Gleason score on biopsy(30% specificity and 100% sensitivity).CONCLUSION:Addition of mp MRI imaging in active surveillance decision making may help in identifying aggressive disease amongst men with indolent prostate cancer earlier than traditional methods. | Larissa J Vos Michele Janoski Keith Wachowicz Atiyah Yahya Oleksandr Boychak John Amanie Nadeem Pervez Matthew B Parliament Edith Pituskin B Gino Fallone Nawaid Usmani | 2016 | World Journal of Radiology2016，8，4： | 1 |
| 13 | Estimating the environmental costs of soil erosion at multiple scales in Kenya using emergy synthesis显示文摘 | Matthew J Mark T Keith D | 2006 | Agriculture Ecosystems & Environment2006，114，： | 1 |
| 14 | Teacher behavior, student interest and affective learning: putting theory to practice显示文摘 | Keith Weber Matthew Martin Brian Patterson | 2001 | Journal of Applied Com- munication Research2001，29，1： | 1 |
| 15 | First principles methods using CASTEP显示文摘 | Stewart J. Clark Matthew D. Segall Chris J. Pickard Phil J. Hasnip Matt I. J. Probert Keith Refson Mike C. Payne | 2005 | Zeitschrift für Kristallographie . 2005 (5/6/)2005，，5： | 1 |
| 16 | Inhi- bition of rat mammary tumorigenesis by concord grape juice constitu- ents显示文摘 | Singletary Keith W Stansbury Matthew J Giusti Monica | 2003 | Journal of Agricultural and Food Chemistry2003，51，25： | 1 |
| 17 | Effects of petroleum resins on asphaltene aggregation and water-in-oil emulsion formation显示文摘 | P Matthew Spiecker Keith L Gawrys Chad B Trail | 2003 | Colloids and Surface- sA: Physicochem Eng Aspects2003，220，： | 1 |
| 18 | Chronic mild stress and sucrose consumption: validity as a model of depression显示文摘 | Forbes NF Caroline A Keith Matthews | 1996 | Physiology Behavior1996，60，： | 1 |
| 19 | Sucrose Consumption as an Hedonic Measure Following Chronic Unpredictable Mild Stress Physiology & Behavior 显示文摘 | Keith Matthews Naida Forbes | 1995 | 57 (2) :241 -2481995，57，2： | 1 |
| 20 | Atherosclerotic aneurysm of the intrathoracic subclavian artery: A case report and review of the literature显示文摘 | Matthew J. Dougherty Keith D. Calligaro Ronald P. Savarese Dominic A. DeLaurentis | 1995 | Journal of Vascular Surgery1995，，3： | 1 |
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