|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 2 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 3 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Brian L Smith Billy M Williams R Keith Oswald | 2002 | Transportation Research Part C2002，，4： | 3 |
| 4 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 5 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Smith B L Williams B M Keith Oswald R | 2002 | Transportation Research Part C2002，10，： | 1 |
| 6 | Comparison of parametric and nonparametric models显示文摘 | Brian L Smith Billy M Williams R Keith Oswald | 2002 | Transportation Research Part C2002，，10： | 1 |
| 7 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Brian L Smith Billy M Williams and R Keith Oswald | 2002 | Transportation Research Part C: Emerging Technologies2002，10，4： | 1 |
| 8 | Factors controlling prolific gas production from low-permeability sandstone reservoirs= Implica- tions for resource assessment, prospect development, and risk analysis显示文摘 | Keith W S Robert M C John W R | 2004 | AAPG Bulletin2004，88，10： | 1 |
| 9 | The effects of load misalignment on tensile load testing of direct bonded orthodontic brackets--a finite element model显示文摘 | Thomas R Keith M | 1994 | Am J Orthod Dentofacial Orthop1994，105，3： | 1 |
| 10 | How many principal components? Stopping rules for determining the number of nontrivial axes revisited 显示文摘 | Pedro R Donald A Keith M | 2005 | Computational Statistics & Data Analysis2005，49，： | 1 |
| 11 | Growth and biomass allocation of shrub and grass seedlings in response to predicted changes in precipitation seasonality 显示文摘 | Perkins Steven R Keith Owens M | 2003 | Plant Ecology2003，1，168： | 1 |
| 12 | Nucleotide sequence of the structural glycoprotein VP7 gene of nebraska calf diarrhea virus rotavirus: comparison with homologous from four strain of human and animal rotavirus显示文摘 | Glass R I Keith J J Nakagomi O et M | 1985 | Virology1985，141，： | 1 |
| 13 | Feasible Flight Paths for Cooperative Generation of a Phantom Radar Track显示文摘 | KEITH B PURVIS CHANDLER P R PACHTER M | 2006 | Journal of Guidance Control and Dynamics2006，29，3： | 1 |
| 14 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Smith Brian L Williams Billy M Oswald Keith R | 2002 | Transportation Research Part C2002，10，： | 1 |
| 15 | Updates in the management of gout 显示文摘 | KEITH M P GILLILAND W R | 2007 | Am J Med2007，120，3： | 1 |
| 16 | Microstrip Antenna Technology 显示文摘 | Keith R C James W M | 1981 | IEEE Trans Antennas Propagat1981，29，1： | 1 |
| 17 | Dissimilatory nitrate reduction by a strain of Desulfovibrio desulfuricans 显示文摘 | Keith S M Herbert R A | 1983 | FEMS Microbiology Letters1983，18，12： | 1 |
| 18 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 19 | Troublesome symptoms in cancer survivors: fatigue, insomnia, neuropathy, and pain 显示文摘 | Pachman Deirdre R Barton Debra L Swetz Keith M | 2012 | J Clin Oncol2012，30，30： | 1 |
| 20 | Lymphoepithelial cysts of the pancreas:a management dilemma显示文摘Pancreatic lymphoepithelial cysts(LECs) are rare,benign lesions that are typically unexpected post-operative pathological findings. We aimed to review clinical, radiological and pathological features of LECs that may allow their preoperative diagnosis. Histopathology databases of two large pancreatic units were searched to identify LECs and notes reviewed to determine patient demographic details, mode of presentation, investigations, treatment and outcome. Five male and one female patients were identified. Their median age was 60 years. Lesions were identified on computed tomography performed for abdominal pain in two patients, and were incidentally observed in four patients. Five LECs were located in the tail and one in the body of the pancreas, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a largely acellular aspirate was yielded. The pre-operative diagnosis was mucinous cystic neoplasm in all patients. This series of patients were treated distal pancreatectomy and splenectomy. A retrospective review of radiological examinations suggested that LECs have a relatively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear more common in elderly males, and are typically incidental, large, unilocular cysts. Close attention to signal intensity on MRI may allow preoperative diagnosis of these lesions. | Julie Martin Keith J Roberts Maria Sheridan Gavin A Falk Daniel Joyce R Matthew Walsh Andrew M Smith Gareth Morris-Stiff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员