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| 1 | Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6显示文摘应力导致的内脏的超敏性在急躁的肠症候群(IBS ) 是相当普通的病人。Probiotics 玩在在 IBS 病人减少内脏的超敏性的一个重要角色。然而,机制清楚地没被阐明。在这研究,我们调查了像点头的受体 pyrin 的角色包含域的蛋白质(NLRP6 ) 6 由应力在 Clostridium 调整 butyricum 的 IBS 导致了。我们的结果证明 NLRP6 在 IBS 组冒号纸巾是下面调整的。另外, IL-18, IL-1, myeloperoxidase (军邮局) , d 乳的酸(D-LA ) ,和 CD172a 在 IBS 组是起来调整的结肠有粘液。在 NLRP6 基因是 silenced 以后, IL-18 和 IL-1 也被增加。病理学的分数建议了低发炎结肠有粘液而非终端回肠。水回避应力() 显示出内脏的超敏性到结肠的扩张。然而,有 Clostridium butyricum 的治疗颠倒了这些结果,施加有益的效果。在结论, Clostridium butyricum 可以由禁止低等级发炎在 IBS 的内脏的超敏性上施加一个有益的行动结肠通过它 NLRP6 上的行动有粘液。 | Kejia Zhao Leimin Yu Xi Wang Yibo He Bin Lu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 10 |
| 2 | 单因素与多因素逻辑回归的不一致性(英文)显示文摘逻辑回归是研究协变量对二元结果影响的一种常用的统计方法。它已被广泛应用于临床试验和观察性研究。然而,单因素回归得到的结果和多元逻辑回归得到的结果往往是相互矛盾的。在多元回归中可能对结果会显示出非常强烈的影响的一个协变量在单因素回归中可能不会,反之亦然。这些事实在生物医学研究中并没有引起足够的重视。误用逻辑回归在医学出版物中非常普遍。在本文中,我们研究了单因素和多因素逻辑回归分析的不一致性,并在多元逻辑回归分析的模型部分中给出建议。 | Hongyue WANG Jing PENG Bokai WANG Xiang LU Julia Z.ZHENG Kejia WANG Xin M.TU Changyong FENG | 2017 | 上海精神医学2017，29，2： | 5 |
| 3 | Polarization-dependent difference of the power spectra from two-dimensional random media with different shapes显示文摘Polarization-dependent difference of the power spectra from a set of two-dimensional (2D) passive random media is investigated by simultaneously solving Maxwell’s equations for both transverse magnetic (TM) and transverse electric (TE) fields. The random media have the same random constitution but different shapes. Results show that both two polarized states are morphology dependent, and the variety of the shapes has more influence on the selection of TM polarized modes than that of TE polarized modes. Such polarization-dependent difference of morphology property presents a new modeselecting technique for random lasers. | LIU Hai LIU JinSong LU JianTao WANG KeJia | 2009 | Chinese Science Bulletin2009，54，18： | 3 |
| 4 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
| 5 | The selection end numerical simulation of merino engineering floating pier structure显示文摘 | Lu Wenbat Su Kejia Xi Ssh | 2011 | Advanced Materials Research vois2011，4705，： | 1 |
| 6 | Antiferroelectric phase transitions ceramics low frequency projector显示文摘以便讨论修改 La 的铅锆酸盐 titanate 锡酸盐 antiferroelectric 陶艺 PbLaZr 的非线性的机电的性质, Sn, TiO3 PLZST,近似线性化的电致伸缩的方程古典线性压电的方程从秒顺序被导出的一模一样的形式概括压电的方程称为。解决非线性的 antiferroelectric 阶段转变陶艺变换器的电声的 transduction 问题的一条分析途径被介绍。PLZST 的非线性的性质能基于为分析变换器的电声的 transduction 问题的近似线性化的电致伸缩的方程与维持的偏爱是线性地相等的。创新 antiferroelectric 陶艺有回声频率 1.1 kHz 的低频率班 IV flextensional 变换器基于途径被开发它作为活跃元素利用 PLZST。湖认证显示为变换器的 PLZST 的使用一会儿在它的 PZT-4 对应物上在在 SL 的 TVR 和 9 dB 增加产出 3 dB 增加,并且途径是有效的。 | LU Kejia LI Junbao XING Jianxin YIN Yilon | 2012 | Chinese Journal of Acoustics2012，31，2： | 1 |
| 7 | Repeating fast radio bursts: Coherent circular polarization by bunches显示文摘Fast radio bursts(FRBs) are millisecond-duration signals that are highly dispersed at distant galaxies. However, the physical origin of FRBs is still unknown. Coherent curvature emission by bunches, e.g., powered by starquakes, has already been proposed for repeating FRBs. It has the nature of understanding narrowband radiation exhibiting time-frequency drifting. Recently, a highly active FRB source, i.e., FRB 20201124A, was reported to enter a newly active episode and emit at least some highly circular-polarized bursts. In this study, we revisit the polarized FRB emission, particularly investigating the production mechanisms of a highly circular polarization(CP) by deriving the intrinsic mechanism and propagative effect. The intrinsic mechanisms of invoking charged bunches are approached with radiative coherence. Consequently, a highly CP could naturally be explained by the coherent summation of outcome waves, generated or scattered by bunches, with different phases and electric vectors. Different kinds of evolutionary trajectories are found on the Poincaré sphere for the bunch-coherent polarization, and this behavior could be tested through future observations. Cyclotron resonance can result in the absorption of R-mode photons at a low altitude region of the magnetosphere, and an FRB should then be emitted from a high-altitude region if the waves have strong linear polarization. Circularly polarized components could be produced from Faraday conversion exhibiting a λ-oscillation, but the average CP fraction depends only on the income wave, indicating a possibility of a highly circular-polarized income wave. The analysis could be welcome if extremely high(e.g., almost 100%) CP from repeating FRBs is detected in the future. Finally, the production of a bulk of energetic bunches in the pulsar-like magnetosphere is discussed, which is relevant to the nature of the FRB central engine. | Wei-Yang Wang Jin-Chen Jiang Jiguang Lu Heng Xu Jiangwei Xu Kejia Lee Jifeng Liu Renxin Xu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 8 | Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques,hyperphosphorylated tau protein,and neurofibrillary tangles in the brain.The overexpression of amyloid-βprecursor protein(APP)in an AD brain results in the binding of APP intracellular domain(AICD)to Fe65 protein via the C-terminal Fe65-PTB2 interaction,which then triggers the secretion of amyloid-βand the consequent pathogenesis of AD.Apparently,targeting the interaction between APP and Fe65 can offer a promising therapeutic approach for AD.Recently,exosome,a type of extracellular vesicle with diameter around 30–200 nm,has gained much attention as a potential delivery tool for brain diseases,including AD,due to their ability to cross the blood–brain barrier,their efficient uptake by autologous cells,and their ability to be surface-modified with target-specific receptor ligands.Here,the engineering of hippocampus neuron cell-derived exosomes to overexpress Fe65,enabled the development of a novel exosome-based targeted drug delivery system,which carried Corynoxine-B(Cory-B,an autophagy inducer)to the APP overexpressed-neuron cells in the brain of AD mice.The Fe65-engineered HT22 hippocampus neuron cell-derived exosomes(Fe65-EXO)loaded with Cory-B(Fe65-EXO-Cory-B)hijacked the signaling and blocked the natural interaction between Fe65 and APP,enabling APP-targeted delivery of Cory-B.Notably,Fe65-EXO-Cory-B induced autophagy in APP-expressing neuronal cells,leading to amelioration of the cognitive decline and pathogenesis in AD mice,demonstrating the potential of Fe65-EXO-Cory-B as an effective therapeutic intervention for AD. | Ashok Iyaswamy Abhimanyu Thakur Xin-Jie Guan Senthilkumar Krishnamoorthi Tsz Yan Fung Kejia Lu Isha Gaurav Zhijun Yang Cheng-Fu Su Kwok-Fai Lau Kui Zhang Roy Chun-Laam Ng Qizhou Lian King-Ho Cheung Keqiang Ye Huanhuan Joyce Chen Min Li | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 9 | Effects of the urban landscape on heatwave-mortality associations in Hong Kong: comparison of different heatwave definitions显示文摘Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change. | Jinglu Song Yi Lu Thomas Fischer Kejia Hu | 2024 | Frontiers of Environmental Science & Engineering2024，18，1： | 0 |
| 10 | Optimal Task Recommendation for Spatial Crowdsourcing with Privacy Control显示文摘Spatial Crowdsourcing(SC)is a transformative platform that engages a crowd of mobile users(i.e.,workers)in collecting and analyzing environmental,social and other spatio-temporal information.However,current solutions ignore the preference of each worker’s remuneration and acceptable distance,and the lack of error analysis after privacy control lead to undesirable task recommendation.In this paper,we introduce an optimization framework for task recommendation while protecting participant privacy.We propose a Generalization mechanism based on Bisecting k-means and an efficient algorithm considering the generalization error to maximization the reward of SC server.Both numerical evaluations and performance analysis are conducted to show the effectiveness and efficiency of the propose framework. | Dan Lu Qilong Han Hongbin Zhao Kejia Zhang | 2017 | 国际计算机前沿大会会议论文集2017，，1： | 0 |
| 11 | Advancing pulsar science with the FAST显示文摘As the rump left behind after an extremely gravity-induced supernova of an evolved massive star,a pulsar is made of cool CBM(i.e.,compressed baryonic matter at a low temperature).Pulsars are not only testbeds for fundamental interactions(e.g.,the nature of gravity[1]and of the strong force at low energies[2]),but also essential tools for detecting nanoHz gravitational waves[3].The pulsar science,whatever,usually depends on the measurement of pulsar radiation,e.g.,pulsar monitoring and timing.Additionally,searching new pulsars for further investigation is also an important focus of this research field.Pulsars have a very good showing,and have never stopped presenting surprises since the first discovery in 1967,because of the continuing development of advanced facilities. | JiGuang Lu KeJia Lee RenXin Xu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，2： | 0 |
| 12 | Spin Evolution of the Magnetar SGR J1935+2154显示文摘Fast radio bursts(FRBs)are short pulses observed in radio frequencies usually originating from cosmological distances.The discovery of FRB 200428 and its X-ray counterpart from the Galactic magnetar SGR J1935+2154suggests that at least some FRBs can be generated by magnetars.However,the majority of X-ray bursts from magnetars are not associated with radio emission.The fact that only in rare cases can an FRB be generated raises the question regarding the special triggering mechanism of FRBs.Here we report long time spin evolution of SGR J1935+2154 until the end of 2022.According to v and v,the spin evolution of SGR J1935+2154 could be divided into two stages.The first stage evolves relatively steady evolution until 2020 April 27.After the burst activity in2020,the spin of SGR J1935+2154 shows strong variations,especially for v.After the burst activity in 2022October,a new spin-down glitch with△v/v=(-7.2±0.6)×10^(-6)is detected around MJD 59876,which is the second event in SGR J1935+2154.At the end,spin frequency and pulse profile do not show variations around the time of FRB 200428 and radio bursts 221014 and 221021,which supply strong clues to constrain the trigger mechanism of FRBs or radio bursts. | Ming-Yu Ge Yuan-Pei Yang Fang-Jun Lu Shi-Qi Zhou Long Ji Shuang-Nan Zhang Bing Zhang Liang Zhang Pei Wang Kejia Lee Weiwei Zhu Jian Li Xian Hou Qiao-Chu Li | 2024 | Research in Astronomy and Astrophysics2024，24，1： | 0 |
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