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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | First principles calculation of stable structure and adhesive strength of plated Ni/Fe(100) or Cu/Fe(100) interfaces显示文摘A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was performed.Ni or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) substrate.Other calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square lattices.The orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) interfaces.This structure was supported by TEM analysis of plated Ni layer on Fe(100) surfaces.The adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) interface.The experimental results of Hull cell iron plated with Ni or Cu supported the results of the calculation.These results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces. | Ryota NAKANISHI Koji SUEOKA Seiji SHIBA M akoto HINO Koji MURAKAMI Ken MURAOKA | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 2 |
| 3 | Creating an infrastructure for autonomous learning: The resource catalogue 显示文摘 | Kenning M M | 1996 | System1996，242，： | 1 |
| 4 | Heat Shock Protein 72: Enhances Manganese Superoxide Dismutase Activity during Myocardial Ischemia-reperfusion Injury Associated with Mitochondrial Protection and Apoptosis Reduction 显示文摘 | Ken S Bari M Iran A S | 2002 | Circulation2002，106，12： | 1 |
| 5 | Air drilling techniques 显示文摘 | Wolke Roy M Deakins Ken Surer Roqer L | 1990 | Geothermal Resources Council Bulletin1990，519，5： | 1 |
| 6 | Soil seed bank of an upland calcareous grassland after 6 years of climate and management manipulations显示文摘 | Olatunde A M ken Thompson Saraha M B | 1998 | Journal of Applied Ecology1998，35，54： | 1 |
| 7 | Type Ⅰ Chiari malformation: a review of the literature 显示文摘 | Jeffery M Michael G Ken M | 2001 | Neurosurg Quart2001，11，3： | 1 |
| 8 | Simultaneous recognition of words and prosody in the Boston university radio speech corpus显示文摘 | HASEGAWA-JOHNSON M CHEN Ken COLE J | 2005 | Speech Communication2005，46，34： | 1 |
| 9 | Different roles for human lung den- dritic cell subsets in pulmonary immune defense mechanisms 显示文摘 | Ingel K D Ken R B Tania M | 2006 | Am J Respir Cell Mol Biol2006，35，4： | 1 |
| 10 | Low temperature synthesis of high quality SrTiO3 films 显示文摘 | SHOJI M SO B B KEN Numata | 2002 | J Vac Soc Jpn2002，45，： | 1 |
| 11 | A review of polymer electrolyte membrane fuel cells:technology,applications,and needs on fundamental research显示文摘 | YUN W KEN C JEFFREY M | 2011 | Applied Energy2011，88，4： | 1 |
| 12 | Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica 显示文摘 | Hsu B Coupar I M Ken N | 2006 | Food Chemistry2006，98，2： | 1 |
| 13 | Characterizationof the Fe/Mn-superoxide dismutase from diatom ( Thallas- siosira weissflogii) : cloning, expression, and property 显示文摘 | Ken C F Hsiung T M Huang Z X | 2005 | Agricultural and Food Chemistry2005，9，： | 1 |
| 14 | Detection of recombinant DNA segments introduced to genetically modified maize (Zea mays)显示文摘 | Takeshi M Hideo K Ken T | | 0，，07： | 1 |
| 15 | Comparison of postoperative volume status and hemodynamics between surgical clipping and endovascular coiling in patients after subarachnoid hemorrhage显示文摘 | Tatsushi M Ken K Yuka Y | 2014 | Journal of Neurosurgical Anesthesiology2014，27，1： | 1 |
| 16 | Fractionation of a light crude oil and identification and quantitation of aliphatic, aro- matic,and biomarker compounds by GC-FID and GC MS显示文摘 | WANG Zhendi FINGAS M F LI Ken | 1994 | Journal of Chromatographic Science1994，32，9： | 1 |
| 17 | Characteirzation of the Fe/Mn-superoxide dismutase from diatom (Thallassiosira weissflogii): Cloning, expression, and property显示文摘 | KEN C F HSIUNG T M HUANG Z X | 2005 | Agricultural and Food Chemistry2005，53，5： | 1 |
| 18 | Value creation and value capture: A multilevel perspective显示文摘 | Lepak D Ken G Smith M | 2007 | The Acade- my of Management Review2007，32，1： | 1 |
| 19 | Geographic distribution of the eastern honeybee, Apis cerana (Hymenoptera: Apidae), across ecological zones in China: Morphological and molecular analyses 显示文摘 | TAN Ken MEIXNER M D FUCHS S | 2006 | Systematics and Biodiversity2006，4，4： | 1 |
| 20 | Cytokine and C-reactive protein profiles induced by porcine circovirus type 2 experimental infection in 3- week-old piglets显示文摘 | Leanne S S Ken M C Isabelle V | 2006 | Viral humunology2006，19，2： | 1 |
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