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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Different roles for human lung den- dritic cell subsets in pulmonary immune defense mechanisms 显示文摘 | Ingel K D Ken R B Tania M | 2006 | Am J Respir Cell Mol Biol2006，35，4： | 1 |
| 3 | Freeman,Cystoventricular Shunting of Intracranial Arachnoid Cysts显示文摘 | Lori A Bride M Ken R | 2003 | Pediatr neurosurg2003，39，6： | 1 |
| 4 | Possible protective role for 3', 4'-dihydroxyflavones induced by enhanced UV-B in a UV-tolerant rice cultivar显示文摘 | Ken R M Gregory J T Malcolm I W | 1998 | Phytochemistry1998，49，： | 1 |
| 5 | Possible protective role for 3',4'-dihydroxyflavones induced by enhanced UV-B in a UV-tolerant rice cultivar显示文摘 | KEN R M GREGORY J T MALCOLM I W | 1998 | Phytochemistry1998，49，7： | 1 |
| 6 | Preglomerular structural changes in the renal vasculature显示文摘 | ANDERSON W P KEN M M EVANS R G | 1995 | Hyperten Blood Press1995，，： | 1 |
| 7 | Analysis of porcine cyto- megalovirus DNA polymerase by consensus primer PCR显示文摘 | Vaaantha R Tomoko T Ken M et a | 1999 | J Vet Med Sci1999，61，11： | 1 |
| 8 | Subcooled flow boiling at high heat flux 显示文摘 | Victor H Del Valle M Kenning D B R | 1985 | International Journal of Heat and Mass Transfer1985，28，10： | 1 |
| 9 | Diagenesis and petrophysics of the early permian moogooloo sandstone, southern Camarvon Basin, western Australia显示文摘 | Julian C B Peter J H Ken R M | 2000 | AAPG Bulletin2000，84，2： | 1 |
| 10 | Short-Term Effects of a Course of Manual Therapy and Exercise in People with Moderate Chronic Obstructive Pulmonary Disease:a Preliminary Clinical Trial 显示文摘 | Roger M E Subramanyam R V Ken B | 2013 | Journal of Manipulative and Physiological Therapeutics2013，36，8： | 1 |
| 11 | Antimicrobial lipids:nat-ural and synthetic fatty acids and monoglycerides显示文摘 | KABARA J J VRABLE R LIE KEN JIE M S F | 1977 | Lipids1977，12，： | 1 |
| 12 | Are there neural gender differences in online trust? An fMRI study on the perceived trustworthiness of EBay offers显示文摘 | Riedl R Hubert M and Kenning P | 2010 | MIS Quarterly2010，34，2： | 1 |
| 13 | Mechanical Fault Detection Based on the Wavelet De-Noising Technique显示文摘 | Li J Zuo M J Ken R Fyfe | 2004 | Journal of Vibration and Acoustic2004，126，1： | 1 |
| 14 | Anatomy and infrastructure of the sporophyte of Takakia ceratophylla显示文摘 | Karen S R Ken D M David K S | 1997 | American Journal of Botany1997，84，10： | 1 |
| 15 | Mechanical fault detection based on the wavelet de-noising technique 显示文摘 | Li J Zuo M J Ken R Fyfe | 2004 | Journal of Vibration and Acoustic2004，126，1： | 1 |
| 16 | Integration of neural networks and expert systems for microscopic wear particle analysis显示文摘 | Ken Xu A R Luxmoore L M Jones | 1998 | Knowledge-Based Systems1998，11，： | 1 |
| 17 | Wnt signaling:a common theme in animal development 显示文摘 | Ken M Cadigan R N | 1997 | Genes Dev1997，11，： | 1 |
| 18 | Saturated flow boiling of water in vertical tubes显示文摘 | KENNING D B R COOPER M G | 1989 | Int J Heat Mass Transfer1989，32，3： | 1 |
| 19 | Carbon clusters near the crossover to fullerene stability显示文摘 | Ken P R Towler M D Needs R J | 2000 | Phys Rev2000，62，： | 1 |
| 20 | Antimicrobial lipids: Natural and synthetic fatty acids and monoglycerides显示文摘 | Kabara J J Vrable R Lie Ken Jie M S F | 1977 | Lipids1977，12，9： | 1 |
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