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	题名	作者	年代	出处	被引量
1	Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia.	Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng	2015	World Journal of Gastroenterology2015，21，42：	2
2	Lymphocy-tic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor显示文摘	Loeffler D A Keng P C Baggs R B	1990	Int J Cancer1990，45，3：	2
3	Barrier Lyapunovfunctions for the control of output-constrained nonlin-ear systems 显示文摘	Keng P T Ge S S Francis E H	2009	Automatica2009，45，4：	1
4	Adaptive neuralcontrol for output feedback nonlinear systems using abarrier Lyapunov function 显示文摘	Bans B R Keng P T Ge S S	2010	IEEE Trasactions onNeural Networks2010，21，8：	1
5	Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin 显示文摘	ActinLee Y J Sheu T J Keng P C	2005	Biochem Biophys Res Commun2005，335，2：	1
6	Drug resistance in Chinese hamster ovary cells during recovery from se- vere hypoxia显示文摘	Wilson R E Keng P C Sutherland R M	1989	J Natl Cancer Inst1989，81，16：	1
7	Adaptive control ofelectrostatic microactuators with bidirectional drive显示文摘	Keng P T Ge S S Francis E H	2009	IEEE Transactions on Control Systems Technolo-gy2009，17，2：	1
8	The discovery of fusuline limestone in the metamorphic complex of Taiwan显示文摘	Yen T P Sheng C C Keng W P	1951	Bulletin of the Geological Survey of Taiwan1951，3，：	1
9	Toxicity of cadmium in human trophoblast cells (Jar choriocarcinoma): role of calmodulin and the calmodulin inhibitor, zaldaride maleate显示文摘	Powlin S S Keng P C Miller R K 1997	1997	Toxicol Appl Pharmacol1997，144，：	1
10	Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis显示文摘	RAHRMANN E P WATSON A L KENG V W	2013	Nat Genet2013，45，：	1
11	显示文摘	Keng P Y Pyun J	2009	ACS Nano2009，3，10：	1
12	The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia celts显示文摘	Rowley P T Keng P C Kosciolek B A	1996	Leuk Res1996，20，6：	1
13	Tracking and vibration control of flexible robots using shape memo- ry alloys 显示文摘	Shuzhi S G Keng P T Ivan E V	2006	IEEE Transactions on Mechatronics2006，11，6：	1
14	Antioxidants reduce consequences of radiation exposure 显示文摘	OkunieffP Swarts S Keng P	2008	Adv Exp Med Bioi2008，614，：	1
15	Phase Ⅰ/Ⅱ clinical study of puLsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines 显示文摘	Chen Y Pandya K Keng P C	2003	Clin Cancer Res2003，9，3：	1
16	Re- lationship between Y-ray-induced G2/M Delay and cellular Radiosensitivity显示文摘	NAGASAW A H KENG P HARLEY R	1994	Original Article1994，66，：	1
17	Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression显示文摘	Chen M F Keng P C Shau H	2006	Int J Radiat Oncol Biol Phys2006，64，2：	1
18	New Bamboos from Szechwan Province,China显示文摘	Keng Y L Keng P C		0，，03：	1
19	Relationship between gamma-ray-induced G2/M delay and cellular radiosensitivity显示文摘	NAGASAWA H KENG P HARLEY R	1994	Int J Radiat Biol1994，66，4：	1
20	Exosome in the ascites of ovari- an cancer patients:origin and effects on anti-tumor im- munity显示文摘	Peng P Yah Y Keng S	2011	Oncol Rep2011，25，3：	1

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