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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 3 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 4 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 5 | Microbial characteristics of soil quality显示文摘 | KENNEDY A C PAPENDICK R I | 1995 | Journal of Soil and Water Conservation1995，50，3： | 1 |
| 6 | Stability of chlor-pyrifos for termiticidal control in six Australian soils显示文摘 | MURRAY R T V0N STEIN C KENNEDY I R | 2001 | J Agric FoodChem2001，49，6： | 1 |
| 7 | Models of SOOT formation and oxi- dation显示文摘 | Kennedy I M | 1997 | Progress in Energy and Combustion Sci- ence1997，23，2： | 1 |
| 8 | Oxidative stress and NFkappaB activation in the lungs of rats:a synergistic interaction between soot and iron particles显示文摘 | Zhou Y M Zhong C Y Kennedy I M | 2003 | Toxicology and Applied Pharmacology2003，190，： | 1 |
| 9 | Shrimp zircon geochronological and geochemical evidence for Neo - Proterozoic arc - related magmatism along the western of the Yangtze Block, South China 显示文摘 | Zhou M F Yah D P Kennedy A K Li Q I and Ding J | 2002 | Earth Planet Sci Lett2002，196，： | 1 |
| 10 | Formaldehyde exposure and asthma in children:A systematic review显示文摘 | Mcgwin G Lienert J Kennedy J I | 2010 | Environ-mental Health Perspectives2010，118，3： | 1 |
| 11 | Social capital, income inequality, and mortality显示文摘 | Kawachi I Kennedy BP Lochnerk | 1997 | American Journal of Public Health1997，，9： | 1 |
| 12 | Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration 显示文摘 | Nichkova M Dosev D Gee S J Hammock B D Kennedy I M | 2007 | Analytical Biochemis- try2007，369，： | 1 |
| 13 | Developing sustainability criteria for urban infrastructure systems 显示文摘 | Sahely H R Kennedy C A Adams B I | 2005 | Canadian Journal of Civil Engineering2005，32，1： | 1 |
| 14 | Phospholipid fatty acid profiles and carbon utilization pattern for analysis of microbial community structure under field and greenhouse conditions显示文摘 | ABASIOFLOK M BEKWE I KENNEDY A C | 1998 | Microbiology Ecology1998，26，： | 1 |
| 15 | Pulmonary responses of acute exposure to ultrafine iron particles in\shealthy adult rats显示文摘 | Zhou Y Zhong C Kennedy I M | 2003 | Environmental Toxicology2003，18，4： | 1 |
| 16 | Associations between health and productivity in cow-calf beef herds and persistent infection with bovine viral diarrhea virus,antibodies against bovine viral diarrhea virus,or antibodies against infectious bovine rhinotracheitis virus in calves显示文摘 | Waldner C L Kennedy R I | 2008 | Am J Vet Res2008，69，7： | 1 |
| 17 | The molecular basis for differential dioxin sensitivity in birds:Role of the aryl hydrocarbon receptor显示文摘 | Karchner S I Franks D G Kennedy S W | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，16： | 1 |
| 18 | Income distribution,socioeconomic status,and self rated health in the United States:multilevel analysis显示文摘 | Kennedy BP Kawachi I Glass R | 1998 | BMJ1998，317，7163： | 1 |
| 19 | Models of soot formation and oxidation显示文摘 | Kennedy I M | 1997 | Progress in Energy and Combustion Science1997，23，2： | 1 |
| 20 | Evaluation of continuous mesophilic anaerobic sludge digestion after high temperature microwave pretreatment显示文摘 | Toteci I Kennedy K J Droste R L | 2009 | Water Research2009，43，5： | 1 |
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